Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Zhiye Hu"'
Autor:
Baohua Xie, Zhinang Yin, Zhiye Hu, Junhui Lv, Chuanqian Du, Xiangping Deng, Yuan Huang, Qiuzi Li, Jian Huang, Kaiwei Liang, Hai-Bing Zhou, Chune Dong
Publikováno v:
Journal of Medicinal Chemistry. 66:6631-6651
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3ffdb46fbe03af5a4dda7686a25cdb
https://doi.org/10.1021/acs.jmedchem.2c02032
https://doi.org/10.1021/acs.jmedchem.2c02032
Autor:
Xiangping Deng, Baohua Xie, Qiuzi Li, Yuan Xiao, Zhiye Hu, Xiaofei Deng, Pingping Fang, Chune Dong, Hai-Bing Zhou, Jian Huang
Publikováno v:
Journal of medicinal chemistry. 65(11)
Breast cancer (BC) is a multifactorial disease and is prone to drug resistance during treatment. In this study, we described a new class of multifunctional estrogen receptor (ER) modulators ground on a prerogative indirect antagonism skeleton (OBHS,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912c443996e5cf406127de108a76b0a1
https://pubmed.ncbi.nlm.nih.gov/35611405
https://pubmed.ncbi.nlm.nih.gov/35611405
Autor:
Hai-Bing Zhou, Zhiye Hu, Jing Zhang, Peng Xueke, Dong Chun'e, Silong Zhang, Wentao Ning, Xiaodong Shi
Publikováno v:
Chemical Communications. 55:14570-14573
Facile synthesis of benzofuranone was achieved through a metal-free, one-pot intermolecular condensation between α-hydroxy aryl ketones and resorcinol derivatives. A library of 20 compounds with moderate to good overall yields was prepared. These co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1bde8cb9e5e10dcc181f95d365ecf0
https://doi.org/10.1039/c9cc05756k
https://doi.org/10.1039/c9cc05756k
Publikováno v:
Sensors and Actuators B: Chemical. 272:589-597
The estrogen receptors (ERα and ERβ) are vital transcription factors that play important role in physiological functions and are responsible for many hormone-regulated diseases. Herein, we report an environment-sensitive fluorescent probe 2 with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52b197bc6be6f66f558e0b01a361d1cc
https://doi.org/10.1016/j.snb.2018.06.022
https://doi.org/10.1016/j.snb.2018.06.022
Autor:
Silong Zhang, Zhiye Hu, Hai-Bing Zhou, Chune Dong, Chu Tang, Lu Yang, Wentao Ning, Jian Huang
Publikováno v:
Journal of Medicinal Chemistry. 61:8155-8173
In this work, we developed a small library of novel OBHS-RES hybrid compounds with dual inhibition activities targeting both the estrogen receptor α (ERα) and NF-κB by incorporating resveratrol (RES), a known inhibitor of NF-κB, into a privileged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2cbd5be39049ca6cccc640fa030b87
https://doi.org/10.1021/acs.jmedchem.8b00224
https://doi.org/10.1021/acs.jmedchem.8b00224
Publikováno v:
Chemical Communications. 54:3887-3890
Estrogen receptor β (ERβ) has recently been identified as a pharmaceutical target in hormone replacement therapy for breast cancers. However, the biological function of ERβ in disease progression remains unclear. A highly ERβ-selective fluorescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af608d8bbaf6a745a0dcdcf9afd048e
https://doi.org/10.1039/c8cc00483h
https://doi.org/10.1039/c8cc00483h
Publikováno v:
Organic & Biomolecular Chemistry. 16:472-479
A series of optically active pyrano[3,2-c]chromenes have been synthesized through an asymmetric domino reaction of 4-hydroxy-2H-chromen-2-ones with malononitriles. The targeted molecules were obtained in excellent yields and enantioselectivities (up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a0699322070b047286121d2ad7b88c
https://doi.org/10.1039/c7ob02794j
https://doi.org/10.1039/c7ob02794j
Autor:
Jing Zhang, Hai-Bing Zhou, Yuan Xiao, Silong Zhang, Shengtang Huang, Chune Dong, Zhiye Hu, Li Yuanyuan, Jian Huang
Publikováno v:
European journal of medicinal chemistry. 172
As the mutant estrogen receptor (ER) continues to be characterized, breast cancer is becoming increasingly difficult to cure when treated with hormone therapy. In this regard, a strategy to selectively and effectively degrade the ER might be an effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb03cc3aca23a53d9de338ef377c86b
https://pubmed.ncbi.nlm.nih.gov/30939353
https://pubmed.ncbi.nlm.nih.gov/30939353
Autor:
Lilan Xin, Chu Tang, Wentao Ning, Hai-Bing Zhou, Jian Huang, Zhiye Hu, Chenxi Zhao, Changhao Li
Publikováno v:
Bioorganic & Medicinal Chemistry. 40:116185
Hormone therapy targeting estrogen receptors is widely used clinically for the treatment of breast cancer, such as tamoxifen, but most of them are partial agonists, which can cause serious side effects after long-term use. The use of selective estrog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351d1174b685fcf06f86ce4b8fcdd2a2
https://doi.org/10.1016/j.bmc.2021.116185
https://doi.org/10.1016/j.bmc.2021.116185
Publikováno v:
European Journal of Medicinal Chemistry. 195:112281
Breast cancer is a multi-factor disease, thus more and more drug combination therapies are applied in the treatment. However, there are undeniable disadvantages in drug combination therapy. Therefore, the development of new dual-targeting drugs has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855f35328f5a2f613d725f11a51a8a27
https://doi.org/10.1016/j.ejmech.2020.112281
https://doi.org/10.1016/j.ejmech.2020.112281