Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Zhiyan Qian"'
Autor:
Emilie A Chapeau, Emeline Mandon, Jason Gill, Vincent Romanet, Nicolas Ebel, Violetta Powajbo, Rita Andraos-Rey, Zhiyan Qian, Miltos Kininis, Sabine Zumstein-Mecker, Moriko Ito, Nancy E Hynes, Ralph Tiedt, Francesco Hofmann, Leonid Eshkind, Ernesto Bockamp, Bernd Kinzel, Matthias Mueller, Masato Murakami, Fabienne Baffert, Thomas Radimerski
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0221635 (2019)
Aberrant activation of the JAK/STAT pathway is thought to be the critical event in the pathogenesis of the chronic myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia and primary myelofibrosis. The most frequent genetic alterat
Externí odkaz:
https://doaj.org/article/a9675b428fbc4f1489023b4044ed239c
Publikováno v:
Shipin Kexue, Vol 44, Iss 13, Pp 112-119 (2023)
The aim of this study was to evaluate the combined effect of gaseous ozone (OG) and perforated modified atmosphere packaging (MAP) on the preservation of Chinese bayberry. In order to determine the optimal storage conditions, different modified atmos
Externí odkaz:
https://doaj.org/article/b2b2cbaeda374d329ecb42c6435f203b
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 841K, Supplementary Figures S1-S6; legends for Supplementary Tables S1-S3; Supplementary Methods describing RNA interference, generation of Ba/F3 cell lines, site-directed mutagenesis, transient transfection, inhibition of cellular ATP pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d1c96f82771189e532e391627afa78
https://doi.org/10.1158/2159-8290.22528301.v1
https://doi.org/10.1158/2159-8290.22528301.v1
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 11K, Activity of NVP-BBT594 in biochemical and cell-based assays. The IC50 (mean of two experiments) of NVP-BBT594 on the JAK2 kinase was determined in a biochemical kinase assay with the active enzyme. Half-maximal growth inhibition (GI50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31418f731a67ae71f974979b4eddf70
https://doi.org/10.1158/2159-8290.22528298
https://doi.org/10.1158/2159-8290.22528298
Autor:
Thomas Radimerski, Fabienne Baffert, Masato Murakami, Francesco Hofmann, Robert Cozens, Dario Sterker, Ernesta Dammassa, Arno Dölemeyer, Zhiyan Qian, Rita Andraos, Claudia Roelli, Vincent Romanet, Nicolas Ebel, Emeline Evrot
Purpose: The myeloproliferative neoplasm myelofibrosis is characterized by frequent deregulation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling, and JAK inhibitors were shown to reduce splenomegaly and amelior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35726eebff08c706c52b9e4e22b2f015
https://doi.org/10.1158/1078-0432.c.6522522.v1
https://doi.org/10.1158/1078-0432.c.6522522.v1
Autor:
Thomas Radimerski, Fabienne Baffert, Masato Murakami, Francesco Hofmann, Robert Cozens, Dario Sterker, Ernesta Dammassa, Arno Dölemeyer, Zhiyan Qian, Rita Andraos, Claudia Roelli, Vincent Romanet, Nicolas Ebel, Emeline Evrot
PDF file 1093K, Supplementary Table S1. Activity and tolerability of ruxolitinib (RUX) and panobinostat (PAN), alone and in combination, in a mouse model of Ba/F3 JAK2V617F cells-driven leukemic disease. Supplementary Table S2. Levels of panobinostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eac12a2a79f2c78f756d1188fd1d345
https://doi.org/10.1158/1078-0432.22452597
https://doi.org/10.1158/1078-0432.22452597
Autor:
Jason Gill, Masato Murakami, Nicolas Ebel, Francesco Hofmann, Bernd Kinzel, Miltos Kininis, Fabienne Baffert, Violetta Powajbo, Moriko Ito, Rita Andraos-Rey, Thomas Radimerski, Emeline Mandon, Ralph Tiedt, Sabine Zumstein-Mecker, Zhiyan Qian, Emilie A. Chapeau, Matthias Mueller, Leonid Eshkind, Ernesto Bockamp, Vincent Romanet, Nancy E. Hynes
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0221635 (2019)
PLoS ONE
PLoS ONE
Aberrant activation of the JAK/STAT pathway is thought to be the critical event in the pathogenesis of the chronic myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia and primary myelofibrosis. The most frequent genetic alterat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a617ee8327eba00e9e27628926f860
https://doaj.org/article/a9675b428fbc4f1489023b4044ed239c
https://doaj.org/article/a9675b428fbc4f1489023b4044ed239c
Autor:
Rubert, Joëlle1, Zhiyan Qian1, Andraos, Rita1, Guthy, Daniel A.1, Radimerski, Thomas1 thomas.radimerski@novartis.com
Publikováno v:
BMC Cancer. 2011, Vol. 11 Issue 1, p24-37. 14p.
Autor:
Robert Cozens, Vincent Romanet, Claudia Roelli, Nicolas Ebel, Thomas Radimerski, Ernesta Dammassa, Arno Dölemeyer, Masato Murakami, Dario Sterker, Zhiyan Qian, Fabienne Baffert, Emeline Evrot, Rita Andraos, Francesco Hofmann
Publikováno v:
Clinical Cancer Research. 19:6230-6241
Purpose: The myeloproliferative neoplasm myelofibrosis is characterized by frequent deregulation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling, and JAK inhibitors were shown to reduce splenomegaly and amelior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb24ead87c23203811843983c1c72f8
https://doi.org/10.1158/1078-0432.ccr-13-0905
https://doi.org/10.1158/1078-0432.ccr-13-0905
Autor:
Debora Bonenfant, Hans Voshol, Thomas Radimerski, Catherine H. Régnier, Carole Pissot-Soldermann, Francesco Hofmann, Alain De Pover, Eric Vangrevelinghe, Zhiyan Qian, Aviva Goel, Clemens Scheufler, Fanny Marque, Hugues Ryckelynck, Priya Koppikar, Paul W. Manley, Christoph Gaul, Lorenza Wyder, Rita Andraos, Fabienne Baffert, Joëlle Rubert, William R. Sellers, Ross L. Levine, Neha Bhagwat, Gisele A. Tavares
Publikováno v:
Cancer discovery. 2(6)
Janus kinase (JAK) inhibitors are being developed for the treatment of rheumatoid arthritis, psoriasis, myeloproliferative neoplasms, and leukemias. Most of these drugs target the ATP-binding pocket and stabilize the active conformation of the JAK ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2c8a24451bfd46f2924a8a79459049
https://pubmed.ncbi.nlm.nih.gov/22684457
https://pubmed.ncbi.nlm.nih.gov/22684457