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Akademický článek

Single-Cell Transcriptome Profiling of Scale Drop Disease Virus-Infected Asian Seabass (Lates calcarifer)

Autor: Zhixuan Loh, Ting Wei Lim, Shanshan Wu Howland, Sunita Awate, Laurent Renia, Jinmiao Chen, Ee Chee Ren

Publikováno v: Aquaculture Journal, Vol 4, Iss 2, Pp 28-43 (2024)

The study aims to characterize the immune cell landscape in convalescent Asian seabass (Lates calcarifer) blood samples after exposure to scale-drop disease virus (SDDV). Traditional immunophenotyping approaches used in human and mouse studies are im

Externí odkaz: https://doaj.org/article/e2f2d75d0c7b458a86053db355363068

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Akademický článek

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling.

Autor: Zhixuan Loh, Jennifer Simpson, Ashik Ullah, Vivian Zhang, Wan J Gan, Jason P Lynch, Rhiannon B Werder, Al Amin Sikder, Katie Lane, Choon Boon Sim, Enzo Porrello, Stuart B Mazzone, Peter D Sly, Raymond J Steptoe, Kirsten M Spann, Maria B Sukkar, John W Upham, Simon Phipps

Publikováno v: PLoS Pathogens, Vol 16, Iss 7, p e1008651 (2020)

Type-2 immunity elicits tissue repair and homeostasis, however dysregulated type-2 responses cause aberrant tissue remodelling, as observed in asthma. Severe respiratory viral infections in infancy predispose to later asthma, however, the processes t

Externí odkaz: https://doaj.org/article/707c4afdce5f46bf961c94b17ce97840

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Akademický článek

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

Autor: Katina D Hulme, Limin Yan, Rebecca J Marshall, Conor J Bloxham, Kyle R Upton, Sumaira Z Hasnain, Helle Bielefeldt-Ohmann, Zhixuan Loh, Katharina Ronacher, Keng Yih Chew, Linda A Gallo, Kirsty R Short

Publikováno v: eLife, Vol 9 (2020)

Diabetes mellitus is a known susceptibility factor for severe influenza virus infections. However, the mechanisms that underlie this susceptibility remain incompletely understood. Here, the effects of high glucose levels on influenza severity were in

Externí odkaz: https://doaj.org/article/c77fdcadf032456989548c4375914ffe

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Akademický článek

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

Autor: Rink-Jan Lohman, Johan K. Hamidon, Robert C. Reid, Jessica A. Rowley, Mei-Kwan Yau, Maria A. Halili, Daniel S. Nielsen, Junxian Lim, Kai-Chen Wu, Zhixuan Loh, Anh Do, Jacky Y. Suen, Abishek Iyer, David P. Fairlie

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Complement C3a is an important protein in innate and adaptive immunity, but its roles in vivo are unclear. Here the authors develop novel chemical agonists and antagonists for the C3a receptor, and show that they modulate mast cell degranulation and

Externí odkaz: https://doaj.org/article/9b55fdd2b33140c08bc5b8dacdba336c

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Akademický článek

The Absence of Interferon-β Promotor Stimulator-1 (IPS-1) Predisposes to Bronchiolitis and Asthma-like Pathology in Response to Pneumoviral Infection in Mice

Autor: Jennifer Simpson, Jason P. Lynch, Zhixuan Loh, Vivian Zhang, Rhiannon B. Werder, Kirsten Spann, Simon Phipps

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract Respiratory syncytial virus (RSV)-bronchiolitis is a major cause of infant morbidity and mortality and a risk factor for subsequent asthma. We showed previously that toll-like receptor (TLR)7 in plasmacytoid dendritic cells (pDCs) is critica

Externí odkaz: https://doaj.org/article/16320a97d87d463db6bea7ee5c251f82

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Akademický článek

RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma

Autor: Jaisy Arikkatt, Md Ashik Ullah, Kirsty Renfree Short, Vivan Zhang, Wan Jun Gan, Zhixuan Loh, Rhiannon B Werder, Jennifer Simpson, Peter D Sly, Stuart B Mazzone, Kirsten M Spann, Manuel AR Ferreira, John W Upham, Maria B Sukkar, Simon Phipps

Publikováno v: eLife, Vol 6 (2017)

Asthma is a chronic inflammatory disease. Although many patients with asthma develop type-2 dominated eosinophilic inflammation, a number of individuals develop paucigranulocytic asthma, which occurs in the absence of eosinophilia or neutrophilia. Th

Externí odkaz: https://doaj.org/article/e418fb7a616e4be3bd804cf4d5fedc33

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Modifying a Hydroxyl Patch in Glucagon-like Peptide 1 Produces Biased Agonists with Unique Signaling Profiles

Autor: Peiqi Wang, Timothy A. Hill, Justin Mitchell, Rebecca L. Fitzsimmons, Weijun Xu, Zhixuan Loh, Jacky Y. Suen, Junxian Lim, Abishek Iyer, David P. Fairlie

Publikováno v: Journal of Medicinal Chemistry. 65:11759-11775

Glucagon-like peptide-1 (GLP-1) lowers blood glucose by inducing insulin but also has other poorly understood properties. Here, we show that hydroxy amino acids (Thr11, Ser14, Ser17, Ser18) in GLP-1(7-36) act in concert to direct cell signaling. Muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b49f968f4f8fdce8a47b3bc1f3761e
https://doi.org/10.1021/acs.jmedchem.2c00653

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Molecular Characterization of MHC Class I Alpha 1 and 2 Domains in Asian Seabass (

Autor: Zhixuan, Loh, Xuelu, Huan, Sunita, Awate, Markus, Schrittwieser, Laurent, Renia, Ee Chee, Ren

Publikováno v: International journal of molecular sciences. 23(18)

The Asian seabass is of importance both as a farmed and wild animal. With the emergence of infectious diseases, there is a need to understand and characterize the immune system. In humans, the highly polymorphic MHC class I (MHC-I) molecules play an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67e268d38f30fc5208e5ebdad1426187
https://pubmed.ncbi.nlm.nih.gov/36142628

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