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Akademický článek

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

Autor: Zhixin Jing, Phillip Galbo, Luis Ovando, Megan Demouth, Skylar Welte, Rosa Park, Kartik Chandran, Yinghao Wu, Thomas MacCarthy, Deyou Zheng, David Fooksman

Publikováno v: eLife, Vol 12 (2024)

Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intravital two-pho

Externí odkaz: https://doaj.org/article/4054696222bc428b9f4c745ce34e05a2

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Akademický článek

TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells

Autor: Hao Wang, R. Alejandro Sica, Gurbakhash Kaur, Phillip M. Galbo, Zhixin Jing, Christopher D. Nishimura, Xiaoxin Ren, Ankit Tanwar, Bijan Etemad-Gilbertson, Britta Will, Deyou Zheng, David Fooksman, Xingxing Zang

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Acute myeloid leukemia (AML) is initiated and sustained by a hierarchy of leukemia stem cells (LSCs), and elimination of this cell population is required for curative therapies. Here we show that transmembrane and immunoglobulin domain conta

Externí odkaz: https://doaj.org/article/a2e33ebf797e44bb8a9fed989423f519

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Akademický článek

Application of Optimal Scheduling Model Based on Improved Genetic Algorithm in Electric Power Mobile Operation

Autor: Rui Fan, Huiying Jing, Zhixin Jing

Publikováno v: IEEE Access, Vol 12, Pp 10946-10960 (2024)

Mobile operation belongs to the innovation of a business model. At present, the management form of mobile operation is still in manual management, and there are many problems in manual management. In order to solve the current situation, an optimized

Externí odkaz: https://doaj.org/article/432f1af29b28423692ab362070640035

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Akademický článek

CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice

Autor: Jamie Moore-Fried, Mahinder Paul, Zhixin Jing, David Fooksman, Gregoire Lauvau

Publikováno v: eLife, Vol 11 (2022)

Plasmacytoid dendritic cells (pDCs) are the most potent producer of type I interferon (IFN), but how pDC is primed in vivo is poorly defined. Using a mouse model of severe malaria, we have previously established that upon priming by CD169+ macrophage

Externí odkaz: https://doaj.org/article/aa653634f5574e27a503e5410d73b946

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Akademický článek

Germinal center expansion but not plasmablast differentiation is proportional to peptide-MHCII density via CD40-CD40L signaling strength

Autor: Zhixin Jing, Mark J. McCarron, Michael L. Dustin, David R. Fooksman

Publikováno v: Cell Reports, Vol 39, Iss 5, Pp 110763- (2022)

Summary: T follicular helper (TFH) cells promote expansion of germinal center (GC) B cells and plasma cell differentiation. Whether cognate peptide-MHCII (pMHCII) density instructs selection and cell fate decisions in a quantitative manner remains un

Externí odkaz: https://doaj.org/article/5dffdefe8835446eb1400765d2c303f5

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Akademický článek

Plasma cell dynamics in the bone marrow niche

Autor: Zachary Benet, Zhixin Jing, David R. Fooksman

Publikováno v: Cell Reports, Vol 34, Iss 6, Pp 108733- (2021)

Summary: Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest.

Externí odkaz: https://doaj.org/article/4591b4b0d6e846498a6cfa03566414a1

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