Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Zhiwei Ang"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Even under normoxia, cancer cells exhibit increased glucose uptake and glycolysis, an occurrence known as the Warburg effect. This altered metabolism results in increased lactic acid production, leading to extracellular acidosis and contributing to m
Externí odkaz:
https://doaj.org/article/9da69e181bf14893b6484c2bf83f3f6a
Autor:
Zhiwei Ang, Ricky Abdi Gunawan Koean, Jun Zhi Er, Li Ting Lee, John Kit Chung Tam, Huili Guo, Jeak Ling Ding
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1008077 (2019)
The role of ribosomal protein S6 (rpS6) phosphorylation in mRNA translation remains poorly understood. Here, we reveal a potential role in modulating the translation rate of chemokine (C-X-C motif) ligand 8 (CXCL8 or Interleukin 8, IL8). We observed
Externí odkaz:
https://doaj.org/article/ef66d414a8e24aeb9831bec48e6e86f4
Autor:
Diana Hooi Ping Low, Zhiwei Ang, Quan Yuan, Vladimir Frecer, Bow Ho, Jianzhu Chen, Jeak Ling Ding
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6260 (2009)
BACKGROUND: Although the human genome database has been completed a decade ago, approximately 50% of the proteome remains hypothetical as their functions are unknown. The elucidation of the functions of these hypothetical proteins can lead to additio
Externí odkaz:
https://doaj.org/article/6350975e4d2c444788f2acdd5a42aab6
Autor:
Andrei Thomas-Tikhonenko, Sarah K. Tasian, Yoseph Barash, Marco Ruella, Kristen W. Lynch, Nathan Singh, Maureen M. O'Brien, Susan R. Rheingold, Deanne M. Taylor, Rawan Shraim, Mukta Asnani, Carolin Schmidt, John Chukinas, Asen Bagashev, David A. Hottman, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Zhiwei Ang, Katharina E. Hayer, Ammar S. Naqvi, Elisabeth Gillespie, Sisi Zheng
Supplementary Data from Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab6aeb24bca7462aba4fb3d2d8eb381
https://doi.org/10.1158/2643-3230.22544534.v1
https://doi.org/10.1158/2643-3230.22544534.v1
Autor:
Zhiwei Ang, Katharina E. Hayer, Manuel Torres Diz, Carolin Schmidt, Sisi Zheng, Feng Xu, Catherine D. Falkenstein, Joseph P. Loftus, Scarlet Y. Yang, Mukta Asnani, Vinodh Pillai, Emeline Chong, Marilyn M. Li, Sarah K. Tasian, Yoseph Barash, Stephen J. Schuster, Andrei Thomas-Tikhonenko
CD20-directed immunotherapies, such as rituximab, are mainstays of clinical management of mature B-cell neoplasms, previously known as non-Hodgkin lymphomas (NHL). More recently, the bispecific CD20/CD3 antibody mosunetuzumab was approved in the EU a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2219f8954f7270cfa97497a1b39ff00
https://doi.org/10.1101/2023.02.19.529123
https://doi.org/10.1101/2023.02.19.529123
Autor:
Nathan Singh, Marco Ruella, Sarah K. Tasian, Mathieu Quesnel-Vallieres, Zhiwei Ang, Rawan Shraim, Sisi Zheng, Kristen W. Lynch, David A Hottman, Mukta Asnani, Ammar S. Naqvi, Maureen M. O'Brien, Carolin Schmidt, Manuel Torres-Diz, Katharina E. Hayer, Asen Bagashev, Yoseph Barash, Susan R. Rheingold, John Chukinas, Andrei Thomas-Tikhonenko, Elisabeth Gillespie, Deanne Taylor
Publikováno v:
Blood Cancer Discov
Downregulation of surface epitopes causes postimmunotherapy relapses in B-lymphoblastic leukemia (B-ALL). Here we demonstrate that mRNA encoding CD22 undergoes aberrant splicing in B-ALL. We describe the plasma membrane–bound CD22 Δex5–6 splice
Autor:
Manuel Torres-Diz, Andrei Thomas-Tikhonenko, Clara Reglero, Adolfo Ferrando, Catherine D Falkenstein, Sarah K Tasian, Priyanka Sehgal, Zhiwei Ang, Yoseph Barash, Caleb Radens
Publikováno v:
Blood. 140:3264-3265
Autor:
Patrick J. Krohl, Justyn Fine, Huilin Yang, Derek VanDyke, Zhiwei Ang, Kook Bum Kim, Andrei Thomas-Tikhonenko, Jamie B. Spangler
Publikováno v:
Cell Rep Methods
Due to their critical functions in cell sensing and signal processing, membrane proteins are highly preferred as pharmacological targets, and antibody drugs constitute the fastest growing category of therapeutic agents on the pharmaceutical market. H
Autor:
Sisi Zheng, Elisabeth Gillespie, Ammar S. Naqvi, Katharina E. Hayer, Zhiwei Ang, Manuel Torres-Diz, Mathieu Quesnel-Vallières, David A. Hottman, Asen Bagashev, John A. Chukinas, Carolin Schmidt, Mukta Mukta Asnani, Rawan Shraim, Deanne M. Taylor, Susan R. Rheingold, Maureen M. O’Brien, Nathan Singh, Kristen W. Lynch, Marco Ruella, Yoseph Barash, Sarah K. Tasian, Andrei Thomas-Tikhonenko
Publikováno v:
Cancer Research. 82:6248-6248
Downregulation of surface epitopes causes post-immunotherapy relapses in B-lymphoblastic leukemia (B-ALL). Here we demonstrate that mRNA encoding CD22 undergoes aberrant splicing in B-ALL. We describe the plasma-membrane-bound CD22 Δex5-6 splice iso
Autor:
Qiman Dong, Li-Feng Zhang, Mehnaz Huq, Wei Li, Peiling Ni, Lingyi Chen, Rosi Chelliah, Bingqing Lin, Siti Nadirah Binte Ismail, Xin Chen, Ru Hong, Udita Chandola, Zhiwei Ang, Lan-Tian Lai
Publikováno v:
Journal of Molecular Biology. 430:2734-2746
Xist (inactivated X chromosome specific transcript) is a prototype long noncoding RNA in charge of epigenetic silencing of one X chromosome in each female cell in mammals. In a genetic screen, we identify Mageb3 and its homologs Mageb1 and Mageb2 as