Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Zhirong Mou"'
Autor:
Romaniya Zayats, Zhirong Mou, Atta Yazdanpanah, Gaurav Gupta, Paul Lopez, Deesha Nayar, Wan H. Koh, Jude E. Uzonna, Thomas T. Murooka
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cutaneous Leishmania major infection elicits a rapid T cell response that is insufficient to clear residually infected cells, possibly due to the accumulation of regulatory T cells in healed skin. Here, we used Leishmania-specific TCR transg
Externí odkaz:
https://doaj.org/article/e9169ab2405b4fc58156443a44308eab
Autor:
Leah S Hohman, Zhirong Mou, Matheus B Carneiro, Gabriel Ferland, Rachel M Kratofil, Paul Kubes, Jude E Uzonna, Nathan C Peters
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009944 (2021)
Intracellular infection with the parasite Leishmania major features a state of concomitant immunity in which CD4+ T helper 1 (Th1) cell-mediated immunity against reinfection coincides with a chronic but sub-clinical primary infection. In this setting
Externí odkaz:
https://doaj.org/article/4c6912c0c3984579bab3f79f849cf3a1
Autor:
Gaurav Gupta, Zhirong Mou, Ping Jia, Rohit Sharma, Romaniya Zayats, Sayonara M. Viana, Lianyu Shan, Aldina Barral, Viviane S. Boaventura, Thomas T. Murooka, Abdel Soussi-Gounni, Camila I. de Oliveira, Jude E. Uzonna
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108513- (2020)
Summary: The long pentraxin 3 (PTX3) plays a critical role in inflammation, tissue repair, and wound healing. Here, we show that PTX3 regulates disease pathogenesis in cutaneous leishmaniasis (CL). PTX3 expression increases in skin lesions in patient
Externí odkaz:
https://doaj.org/article/aaefd71d64124fd1a867b9f493e7fb4a
Autor:
Weili Wang, Juan Cai, Sha Tang, Ying Zhang, Xuejing Gao, Lijiao Xie, Zhirong Mou, Yuzhang Wu, Li Wang, Jingbo Zhang
Publikováno v:
Kidney & Blood Pressure Research, Vol 41, Iss 2, Pp 158-167 (2016)
Background/Aims: Sinomenine, a pure alkaloid extracted from the Chinese medicinal plant Sinomenium acutum, and sinomenine hydrochloride (SN) has been successfully used for the therapy of rheumatoid arthritis (RA) and kidney diseases. Autophagy is a c
Externí odkaz:
https://doaj.org/article/7cd92db4cc9a4990a034be343650be06
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135528 (2015)
Cancer stem cells (CSCs) can invade and metastasize by epithelial-to-mesenchymal transition (EMT). However, how they escape immune surveillance is unclear. B7H1 is crucial negative co-stimulatory molecule but little information about whether it works
Externí odkaz:
https://doaj.org/article/a6dcedd78b504b9694e35f635e7a9aa8
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004396 (2014)
Although it is generally believed that CD4(+) T cells play important roles in anti-Leishmania immunity, some studies suggest that they may be dispensable, and that MHC II-restricted CD3(+)CD4(-)CD8(-) (double negative, DN) T cells may be more importa
Externí odkaz:
https://doaj.org/article/df4ae6c1ef3a4899a06dc113125fab3d
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 6, p e2951 (2014)
Visceral leishmaniasis is the most clinically relevant and dangerous form of human leishmaniasis. Most traditional drugs for treatment of leishmaniasis are toxic, possess many adverse reactions and drug resistance is emerging. Therefore, there is urg
Externí odkaz:
https://doaj.org/article/42a56213bf0f4b3287df081c0ce2d35a
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3300 (2014)
We previously showed that CD8+ T cells are required for optimal primary immunity to low dose Leishmania major infection. However, it is not known whether immunity induced by low dose infection is durable and whether CD8+ T cells contribute to seconda
Externí odkaz:
https://doaj.org/article/eaebecd400454f8d9fe01f7e56998b35
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66058 (2013)
Despite inducing very low IFN-γ response and highly attenuated in vivo, infection of mice with phosphoglycan (PG) deficient Leishmania major (lpg2-) induces protection against virulent L. major challenge. Here, we show that mice infected with lpg2-
Externí odkaz:
https://doaj.org/article/f37a1bae26814e27baa199e3fc305ebe
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1761 (2012)
BACKGROUND: BALB/c mice are highly susceptible while C57BL/6 are relatively resistant to experimental Trypanosoma congolense infection. Although regulatory T cells (Tregs) have been shown to regulate the pathogenesis of experimental T. congolense inf
Externí odkaz:
https://doaj.org/article/fa87cf5d24d445edbba18c71052cfd00