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A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Autor:
Jordi Carreras-Puigvert, Marinka Zitnik, Ann-Sofie Jemth, Megan Carter, Judith E. Unterlass, Björn Hallström, Olga Loseva, Zhir Karem, José Manuel Calderón-Montaño, Cecilia Lindskog, Per-Henrik Edqvist, Damian J. Matuszewski, Hammou Ait Blal, Ronnie P. A. Berntsson, Maria Häggblad, Ulf Martens, Matthew Studham, Bo Lundgren, Carolina Wählby, Erik L. L. Sonnhammer, Emma Lundberg, Pål Stenmark, Blaz Zupan, Thomas Helleday
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
The NUDIX hydrolases are known to be involved in several cellular processes and diseases, such as cancer, but remain poorly characterized as a family. Here, the authors provide a comprehensive analysis of the structural, biochemical, and expression p
Externí odkaz:
https://doaj.org/article/6564fe588369406e87c0d1e279e7b8c4
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Autor:
Judith E. Unterlass, Thomas Helleday, Olga Loseva, Ulf Martens, Hammou Ait Blal, José Manuel Calderón-Montaño, Carolina Wählby, Jordi Carreras-Puigvert, Blaz Zupan, Ronnie P.-A. Berntsson, Cecilia Lindskog, Zhir Karem, Erik L. L. Sonnhammer, Maria Häggblad, Per-Henrik Edqvist, Pål Stenmark, Emma Lundberg, Björn M. Hallström, Matthew Studham, Marinka Zitnik, Megan Carter, Ann-Sofie Jemth, Bo Lundgren, Damian J. Matuszewski
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications
The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing. Although highly conserved throughout all organisms, their biological roles and biochemical redundancies remain largely unclear. To address this, we glo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdfe6a3975841a5922701e68d4c166d
https://doi.org/10.1038/s41467-017-01642-w
https://doi.org/10.1038/s41467-017-01642-w