Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Zhiqun Zhou"'
Autor:
Seyedeh Fatemeh Razavipour, Hyunho Yoon, Kibeom Jang, Minsoon Kim, Hend M. Nawara, Amir Bagheri, Wei-Chi Huang, Miyoung Shin, Dekuang Zhao, Zhiqun Zhou, Derek Van Boven, Karoline Briegel, Lluis Morey, Tan A. Ince, Michael Johnson, Joyce M. Slingerland
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In many cancers, a stem-like cell subpopulation mediates tumor initiation, dissemination and drug resistance. Here, we report that cancer stem cell (CSC) abundance is transcriptionally regulated by C-terminally phosphorylated p27 (p27pT157pT
Externí odkaz:
https://doaj.org/article/7bf3e62bafb2439da609657ec68e47b4
Autor:
Jashodeep Datta, Nipun B. Merchant, Dmitry I. Gabrilovich, Ben Z. Stanger, Eneda Toska, Alejandro V. Villarino, Krishna Komanduri, Roberta Brambilla, William L. Hwang, Elizabeth A. Montgomery, Nagaraj S. Nagathihalli, Carina Shiau, Yuguang Ban, Jian Zhang, Ifeanyichukwu C. Ogobuiro, Haleh Amirian, Oliver Umland, Zhiqun Zhou, Austin R. Dosch, Christine I. Rafie, Eric Wieder, Shannon J. Saigh, Despina S. Kolonias, Luis A. Nivelo, Xinyu Guo, Vanessa T. Garrido, Siddharth Mehra, Samara Singh, Nilesh U. Deshpande, Iago De Castro Silva, Anna Bianchi
We have shown that KRAS–TP53 genomic coalteration is associated with immune-excluded microenvironments, chemoresistance, and poor survival in pancreatic ductal adenocarcinoma (PDAC) patients. By treating KRAS–TP53 cooperativity as a model for hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c006c946ca4358d4c3811305ca5a79
https://doi.org/10.1158/2159-8290.c.6655455.v1
https://doi.org/10.1158/2159-8290.c.6655455.v1
Autor:
Jashodeep Datta, Nipun B. Merchant, Dmitry I. Gabrilovich, Ben Z. Stanger, Eneda Toska, Alejandro V. Villarino, Krishna Komanduri, Roberta Brambilla, William L. Hwang, Elizabeth A. Montgomery, Nagaraj S. Nagathihalli, Carina Shiau, Yuguang Ban, Jian Zhang, Ifeanyichukwu C. Ogobuiro, Haleh Amirian, Oliver Umland, Zhiqun Zhou, Austin R. Dosch, Christine I. Rafie, Eric Wieder, Shannon J. Saigh, Despina S. Kolonias, Luis A. Nivelo, Xinyu Guo, Vanessa T. Garrido, Siddharth Mehra, Samara Singh, Nilesh U. Deshpande, Iago De Castro Silva, Anna Bianchi
Differentially expressed pathways comparing transcriptomes in KRAS-TP53 co-altered (n=23) and KRAS-altered/TP53WT (n=5) derived from Cancer Cell Line Encyclopedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92246783d8a78ae68e4fcb7019f7aad2
https://doi.org/10.1158/2159-8290.22960614
https://doi.org/10.1158/2159-8290.22960614
Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer
Autor:
Joyce Slingerland, Claes Wahlestedt, Diana Azzam, Zhiqun Zhou, Derek Van Booven, Gray Pearson, Apsra Nasir, Andrew J. Ewald, Matthew Dunworth, Kuzhuvelil B. Harikumar, Seyedeh Fatemeh Razavipour, Hetakshi Kurani
Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b2c2a99ceb52ac7539304e737c3627
https://doi.org/10.1158/1078-0432.22482617
https://doi.org/10.1158/1078-0432.22482617
Autor:
Joyce Slingerland, Claes Wahlestedt, Diana Azzam, Zhiqun Zhou, Derek Van Booven, Gray Pearson, Apsra Nasir, Andrew J. Ewald, Matthew Dunworth, Kuzhuvelil B. Harikumar, Seyedeh Fatemeh Razavipour, Hetakshi Kurani
Supplementary Data from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fac0b031926614dedc58a978f1c7414
https://doi.org/10.1158/1078-0432.22482626
https://doi.org/10.1158/1078-0432.22482626
Autor:
Joyce Slingerland, Claes Wahlestedt, Diana Azzam, Zhiqun Zhou, Derek Van Booven, Gray Pearson, Apsra Nasir, Andrew J. Ewald, Matthew Dunworth, Kuzhuvelil B. Harikumar, Seyedeh Fatemeh Razavipour, Hetakshi Kurani
Purpose:Although chemotherapies kill most cancer cells, stem cell–enriched survivors seed metastasis, particularly in triple-negative breast cancers (TNBC). TNBCs arise from and are enriched for tumor stem cells. Here, we tested if inhibition of DO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff6911188d18d2441b87c3db864aa18
https://doi.org/10.1158/1078-0432.c.6530972.v1
https://doi.org/10.1158/1078-0432.c.6530972.v1
Autor:
Hetakshi Kurani, Seyedeh Fatemeh Razavipour, Kuzhuvelil B. Harikumar, Matthew Dunworth, Andrew J. Ewald, Apsra Nasir, Gray Pearson, Derek Van Booven, Zhiqun Zhou, Diana Azzam, Claes Wahlestedt, Joyce Slingerland
Publikováno v:
Clinical Cancer Research. 28:1948-1965
Purpose: Although chemotherapies kill most cancer cells, stem cell–enriched survivors seed metastasis, particularly in triple-negative breast cancers (TNBC). TNBCs arise from and are enriched for tumor stem cells. Here, we tested if inhibition of D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f352954c889250ee10c3080fdb9bdb8
https://doi.org/10.1158/1078-0432.ccr-21-1299
https://doi.org/10.1158/1078-0432.ccr-21-1299
Autor:
Samara Singh, Austin R. Dosch, Siddharth Mehra, Iago de Castro Silva, Anna Bianchi, Vanessa Tonin Garrido, Zhiqun Zhou, Haleh Amirian, Edmond W. Box, Jashodeep Datta, Nagaraj Nagathihalli, Nipun B. Merchant
Publikováno v:
Cancer Research. 83:3627-3627
Introduction: Pancreatic ductal adenocarcinoma (PDAC) continues to face major therapeutic challenges due to its innate and acquired chemoresistance. Oncogenic, activating KRAS mutations facilitate extensive cytokine-mediated crosstalk between tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8bc93582868e9b350fdc6a456fa7603
https://doi.org/10.1158/1538-7445.am2023-3627
https://doi.org/10.1158/1538-7445.am2023-3627
Autor:
Anna Bianchi, Iago De Castro Silva, Nilesh Deshpande, Samara Singh, Siddharth Mehra, Vanessa Garrido, Ifeanyichukwu Ogobuiro, Haleh Amirian, Christine Rafie, Zhiqun Zhou, Nagaraj Nagathihalli, Alejandro Villarino, Nipun Merchant, Jashodeep Datta
Publikováno v:
Cancer Research. 83:2879-2879
Objective: We have shown that KRAS-TP53 genomic co-alteration is associated with immune-excluded microenvironments, chemoresistance, and poor survival in pancreatic ductal adenocarcinoma (PDAC) patients. By treating KRAS-TP53 cooperativity as a model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ab6a3eb5d20e70fc9b34c99626a5619
https://doi.org/10.1158/1538-7445.am2023-2879
https://doi.org/10.1158/1538-7445.am2023-2879
Autor:
Siddharth Mehra, Vanessa Garrido, Samara Singh, Iago De Castro Silva, Zhiqun Zhou, Supriya Srinivasan, Luis Alberto Nivelo, Anna Bianchi, Andrew Adams, Haleh Amirian, Lluis Morey, Ban Yuguang, Alejandro Villarino, Jashodeep Datta, Nipun Merchant, Nagaraj Nagathihalli
Publikováno v:
Cancer Research. 83:653-653
Background: Pancreatic ductal adenocarcinoma (PDAC) due to its unique genetic makeup and immunosuppressive tumor microenvironment (TME) produce a lack of response to current therapies. Macrophages, constitute a large innate immune subset and play a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4a7bf2471561b85010487b4728d8f47
https://doi.org/10.1158/1538-7445.am2023-653
https://doi.org/10.1158/1538-7445.am2023-653