Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Zhiqing Fang"'
Autor:
Jie Hao, Ziyi Huang, Siyue Zhang, Kefan Song, Juncheng Wang, Chao Gao, Zhiqing Fang, Ning Zhang
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107437- (2024)
Increasing evidence indicates that 2-hydroxyglutarate (2HG) is an oncometabolite that drives tumour formation and progression. Due to mutations in isocitrate dehydrogenase (IDH) and the dysregulation of other enzymes, 2HG accumulates significantly in
Externí odkaz:
https://doaj.org/article/a44eb202a8114a91a4e2b19f89e3d9a9
Autor:
Zhaoqi Kang, Shuang Hou, Kaiyu Gao, Yidong Liu, Ning Zhang, Zhiqing Fang, Wen Zhang, Xianzhi Xu, Rong Xu, Chuanjuan Lü, Cuiqing Ma, Ping Xu, Chao Gao
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract l‐2‐Hydroxyglutarate (l‐2‐HG) is a functionally compartmentalized metabolite involved in various physiological processes. However, its subcellular distribution and mitochondrial transport remain unclear owing to technical limitations
Externí odkaz:
https://doaj.org/article/1b32324d772c4f83858128fa448695db
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Cancer-associated fibroblasts (CAFs) drive cancer progression and treatment failure on one hand, while their tumor-restraining functions are also observed on the other. Recent single cell RNA sequencing (scRNA-seq) analyses demons
Externí odkaz:
https://doaj.org/article/fa8f2caf8cd44ea2ab04fba749773b4b
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107234- (2024)
After the initial androgen deprivation therapy (ADT), part of the prostate cancer may continuously deteriorate into castration-resistant prostate cancer (CRPC). The majority of patients suffer from the localized illness at primary diagnosis that coul
Externí odkaz:
https://doaj.org/article/364ce6bf959a46618f61dcba2c1d960b
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Background Clear cell renal cell carcinoma (ccRCC) displays sex-biased incidence, outcomes, molecular alterations and treatment efficacy; however, clinical managements are largely identical in male and female patients. Moreover, many biomark
Externí odkaz:
https://doaj.org/article/4778c05e533a47f4b32da7b57de2b53b
Autor:
Jing Wang, Mingkai Dai, Xiangling Xing, Xing Wang, Xin Qin, Tao Huang, Zhiqing Fang, Yidong Fan, Dawei Xu
Publikováno v:
Molecular Oncology, Vol 17, Iss 1, Pp 150-172 (2023)
Telomerase activation is required for malignant transformation. Recent advances in high‐throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensiv
Externí odkaz:
https://doaj.org/article/d36c388e58034e61845a262802e40a69
Autor:
Chang Wang, Xin Qin, Wei Guo, Jing Wang, Li Liu, Zhiqing Fang, Huiyang Yuan, Yidong Fan, Dawei Xu
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundChromosomal instability (CIN) is a cancer hallmark and it is difficult to directly measure its phenotype, while a CIN25 gene signature was established to do so in several cancer types. However, it is currently unclear whether there exists t
Externí odkaz:
https://doaj.org/article/dc53515efbcb46fe8ca8377cb89b8afc
Autor:
Zhiqing Fang, Ning Zhang, Xiaotian Yuan, Xiangling Xing, Xiaofeng Li, Xin Qin, Zhengfang Liu, Shiyong Neo, Cheng Liu, Feng Kong, Magnus Björkholm, Yidong Fan, Dawei Xu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-20 (2022)
Abstract Background The ETS transcription factor GABPA has long been thought of as an oncogenic factor and recently suggested as a target for cancer therapy due to its critical effect on telomerase activation, but the role of GABPA in clear cell rena
Externí odkaz:
https://doaj.org/article/71d95ec604714ade8d9cb74a24730485
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114193- (2023)
DNA helicases are essential to genomic stability by regulating DNA metabolisms and their loss-of-function mutations lead to genomic instability and predisposition to cancer. Paradoxically, overexpression of DNA helicases is observed in several cancer
Externí odkaz:
https://doaj.org/article/1082d42e8660468aac874016e4c46468
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background On the basis of some significant clinical parameters, we had an intent to establish nomograms for estimating the prognosis of patients with squamous cell carcinoma of the urinary bladder (SCCB), including overall survival (OS) and
Externí odkaz:
https://doaj.org/article/18b65d34c43540d7b9034a96f81ebf9d