Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zhiping You"'
Publikováno v:
The AAPS Journal. 24
Characterization of clinical anti-drug antibody (ADA) responses to biotherapeutics can be important to understanding the consequences of immunogenicity. ADA are expected to be polyclonal, with composition and affinities that evolve over time. Measuri
Autor:
Zhihua Jiang, Boris Gorovits, Elena Seletskaia, Gregory S. Steeno, Soma Basak, John Kamerud, Zhiping You
Publikováno v:
Bioanalysis. 13(14)
Aim: To investigate the feasibility of singlicate analysis in anti-drug antibody (ADA) assay by comparing performance characteristics for assays qualified in duplicate and singlicate formats. Materials & methods: We employed modeling to assess and qu
Autor:
Dean Messing, Lisa Dyleski, Sarah J Crowell, Boris Gorovits, Zhiping You, Sarah Murphy, Alison Joyce, Meghan Gomes, Jennifer Cargill, Ying Wang
Publikováno v:
Pharmaceutical research. 38(5)
The purpose of this study was to evaluate the suitability of whole blood microsampling procedures in non-human primate (NHP) to support toxicokinetic assessments of biotherapeutics in non-human primates. A one-month single dose intravenous pharmacoki
Autor:
Christopher Lepsy, Zhiping You, Gregory S. Steeno, Saleem Shaik, Dilki Wickramarachchi, Li Xue
Publikováno v:
The AAPS journal. 22(5)
Validation of key analytical and functional performance characteristics of in vitro immunogenicity risk assessment assays increases our confidence in utilizing them for screening biotherapeutics. Herein, we present a fit-for-purpose (FFP) validation
Autor:
Zhiping You, Boris Gorovits, John Kamerud, Daniel Baltrukonis, Puneet Gaitonde, Chun-Hua Cai, Gregory S. Steeno, Charles Tan
Publikováno v:
The AAPS journal. 22(2)
After tier 1 and 2 cut points for anti-drug antibody (ADA) assays are derived during pre-study assay validation in a population, there is a need to verify the continued appropriateness of the previously derived cut points during sample analysis in th
Publikováno v:
Journal of Aquatic Food Product Technology. 24:824-831
In order to produce a fermented seasoning of Antarctic krill juice with pleasant taste and unique flavor, the Antarctic krill juice was fermented by application of Aspergillus oryzae, Streptococcus thermophilus, Saccharomyces cerevisiae, and Bacillus
Autor:
Mahantappa Halimani, Kondala Atkuri, Polina Goiberg, Zhiping You, Greg Steeno, Sophie Tourdot, Li Xue, Chris Lepsy, Tim Hickling, Lindsay King
Publikováno v:
The Journal of Immunology. 202:130.36-130.36
The objective of this research was to develop an in vitro dendritic cell based assay to assess if differences in internalization of biotherapeutic drugs (BioTx) and/or intra-cellular trafficking could be measured and used to help predict clinical imm
Publikováno v:
Journal of Chemical Information and Modeling. 50:565-571
The pK(a) values of 211 discovery (druglike) compounds were determined experimentally using capillary electrophoresis coupled with ultraviolet spectroscopy and a novel fitting algorithm. These values were compared to those predicted by five different
Autor:
Virna J A Schuck, Grant K. Walkup, Stewart L. Fisher, Ed T. Buurman, David E. Ehmann, Michele Johnstone, Fereidoon Daryaee, Laurel Hajec, Michael R. Hale, Allison Laura Choy, Sara A. Patey, Zhiping You, Kerry E. Murphy-Benenato, Valerie Marone, Lena A Grosser, Philip L. Ross, Stephen G. Walker, John O'Donnell, Eleanor K. H. Allen, Peter J. Tonge
Many drug candidates fail in clinical trials owing to a lack of efficacy from limited target engagement or an insufficient therapeutic index. Minimizing off-target effects while retaining the desired pharmacodynamic (PD) response can be achieved by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20caa4d0aff3f316fda11431229c47d
https://europepmc.org/articles/PMC4536915/
https://europepmc.org/articles/PMC4536915/
Publikováno v:
Physica D: Nonlinear Phenomena. 93:210-222
A numerical procedure is described that can accurately compute the stable manifold of a saddle fixed point for a map of R2, even if the map has no inverse. (Conventional algorithms use the inverse map to compute an approximation of the unstable manif