Zobrazeno 1 - 10
of 847
pro vyhledávání: '"Zhiping, Weng"'
Autor:
Wenjun Chen, Jordan S. Brown, Tao He, Wei-Sheng Wu, Shikui Tu, Zhiping Weng, Donglei Zhang, Heng-Chi Lee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Phase separated, membrane-less germ granules preserve fertility and cellular function in animal germ cells. Here the authors show that loss of germ granules impacts piRNA pathway fidelity in the recognition of self and non-self nucleic acids.
Externí odkaz:
https://doaj.org/article/d8b863c6d92b413c8d5717dec515c6bb
Autor:
Lin Jin, Mahendra P. Kashyap, Yunjia Chen, Jasim Khan, Yuanyuan Guo, Jari Q. Chen, Madison B. Lee, Zhiping Weng, Allen Oak, Prasanth Patcha, Tiffany Mayo, Rajesh Sinha, Venkatram Atigadda, Shahid M. Mukhtar, Jessy S. Deshane, Chander Raman, Carly Elston, Boni E. Elewski, Craig A. Elmets, Mohammad Athar
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106896- (2023)
Summary: Hidradenitis suppurativa (HS) is a skin disorder that causes chronic painful inflammation and hyperproliferation, often with the comorbidity of invasive keratoacanthoma (KA). Our research, employing high-resolution immunofluorescence and dat
Externí odkaz:
https://doaj.org/article/0de4db9502ab4617909eb859b7c9b5e5
Autor:
Arjan van der Velde, Kaili Fan, Junko Tsuji, Jill E. Moore, Michael J. Purcaro, Henry E. Pratt, Zhiping Weng
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
van der Velde et al. present a resource for understanding changes in chromatin states during mouse prenatal development. The authors annotate ATAC-seq, whole-genome bisulfite sequencing, and ChIP-seq of data from Phase III of the ENCODE Project and f
Externí odkaz:
https://doaj.org/article/072d42cc11dc4315b1f415caf2caf81e
Autor:
Tianxiong Yu, Kaili Fan, Deniz M. Özata, Gen Zhang, Yu Fu, William E. Theurkauf, Phillip D. Zamore, Zhiping Weng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The pachytene piRNA loci are transcribed by RNA polymerase II in the male germline of placental mammals. Here the authors show that a long first exon or a long unspliced transcript correlates with germline-specific production of piRNA precursor trans
Externí odkaz:
https://doaj.org/article/1760126de9e147de89acee694ee12b89
Autor:
Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, Hillary C. Valley, Xiao-Ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu, Wen Xue
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.
Externí odkaz:
https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
Autor:
Sergio Espeso-Gil, Tobias Halene, Jaroslav Bendl, Bibi Kassim, Gabriella Ben Hutta, Marina Iskhakova, Neda Shokrian, Pavan Auluck, Behnam Javidfar, Prashanth Rajarajan, Sandhya Chandrasekaran, Cyril J. Peter, Alanna Cote, Rebecca Birnbaum, Will Liao, Tyler Borrman, Jennifer Wiseman, Aaron Bell, Michael J. Bannon, Panagiotis Roussos, John F. Crary, Zhiping Weng, Stefano Marenco, Barbara Lipska, Nadejda M. Tsankova, Laura Huckins, Yan Jiang, Schahram Akbarian
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-19 (2020)
Abstract Background Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ)
Externí odkaz:
https://doaj.org/article/12c3984af6c44601a2a73a399133c309
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background Many genome-wide collections of candidate cis-regulatory elements (cCREs) have been defined using genomic and epigenomic data, but it remains a major challenge to connect these elements to their target genes. Results To facilitate
Externí odkaz:
https://doaj.org/article/d3e9a66b83c6421cb2a86af791ed97cf
Autor:
Alison P. Casserly, Junko Tsuji, Rubing Zhao-Shea, Ciearra B. Smith, Susanna Molas, Andrew R. Tapper, Zhiping Weng, Paul D. Gardner
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Tobacco use is the leading preventable cause of mortality in the world. The limited number of smoking cessation aids currently available are minimally effective, highlighting the need for novel therapeutic interventions. We describe a genome
Externí odkaz:
https://doaj.org/article/34279bfdabda45b49d57ee942945b463
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0264799 (2022)
MafB (a bZIP transcription factor), ß-catenin (the ultimate target of the Wnt signal transduction pathway that acts as a transcriptional co-activator of LEF/TCF proteins), and WDR77 (a transcriptional co-activator of multiple hormone receptors) are
Externí odkaz:
https://doaj.org/article/b068deefc49c4ced8be6f1ab15c7ed0a
Autor:
Junko Tsuji, Travis Thomson, Christine Brown, Subhanita Ghosh, William E. Theurkauf, Zhiping Weng, Lawrence M. Schwartz
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
PIWI-interacting RNAs (piRNAs) are small single-stranded RNAs that can repress transposon expression via epigenetic silencing and transcript degradation. They have been identified predominantly in the ovary and testis, where they serve essential role
Externí odkaz:
https://doaj.org/article/885a4f5eb70e4d7c829c4646687b6d25