Výsledky vyhledávání - "Zhinuo J, Wang"

Akademický článek

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy

Autor: Raffaele Coppini, MD, PhD, Cecilia Ferrantini, MD, PhD, Josè Manuel Pioner, PhD, Lorenzo Santini, MS, Zhinuo J. Wang, PhD, Chiara Palandri, MS, Marina Scardigli, PhD, Giulia Vitale, MS, Leonardo Sacconi, PhD, Pierluigi Stefàno, MD, Laura Flink, MD, Katherine Riedy, MD, Francesco Saverio Pavone, PhD, Elisabetta Cerbai, PhD, Corrado Poggesi, MD, Alessandro Mugelli, MD, Alfonso Bueno-Orovio, PhD, Iacopo Olivotto, MD, Mark V. Sherrid, MD

Publikováno v: JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 795-813 (2019)

Summary: Disopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular and molecular mechanisms of action are unknown. We tested disopyramide in cardiomyocytes from the septum of surgical myectomy

Externí odkaz: https://doaj.org/article/383410aaa4f04130b18b186ad5f7d1d6

Zobrazit plný text záznamu

In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment

Autor: Mariano Vázquez, Alfonso Santiago, Alfonso Bueno-Orovio, Blanca Rodriguez, Francesca Margara, Zhinuo J. Wang, Francesc Levrero-Florencio

Publikováno v: Progress in Biophysics and Molecular Biology
OpenAIRE
PubMed Central
UnpayWall
ORCID
Microsoft Academic Graph
Sygma

Human-based computational modelling and simulation are powerful tools to accelerate the mechanistic understanding of cardiac patho-physiology, and to develop and evaluate therapeutic interventions. The aim of this study is to calibrate and evaluate h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f5102b0bbc233b1af7bc652ae25f38

Zobrazit plný text záznamu

Post myocardial infarction ionic remodelling promotes repolarisation dispersion and electrocardiogram abnormalities in acute and chronic stages

Autor: Jakub Tomek, Xin Zhou, Linwei Wang, Zhinuo J. Wang, Blanca Rodriguez

Publikováno v: EP Europace. 23

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Wellcome Trust Background Sudden cardiac death (SCD) occurs in both acute and chronic stages post myocardial infarction (MI), and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::279ba88723e30587c71b5023412a88b5
https://doi.org/10.1093/europace/euab116.575

Zobrazit plný text záznamu

Sensitivity of Myocardial Stiffness Estimates to Inter-observer Variability in LV Geometric Modelling

Autor: Debbie Zhao, Bianca Freytag, Thiranja P. Babarenda Gamage, Alistair A. Young, Charlene Mauger, Vicky Y. Wang, Jie Jane Cao, Martyn P. Nash, Abdallah I. Hasaballa, Kathleen Gilbert, Zhinuo J. Wang

Publikováno v: Functional Imaging and Modeling of the Heart ISBN: 9783030787097
FIMH

Heart failure is known to be associated with substantial changes in the mechanical properties of the heart muscle. Biomechanical parameters, such as myocardial stiffness, have the potential to help clinicians diagnose and determine and monitor treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1b30447e2936733fafaca1801493f2c
https://doi.org/10.1007/978-3-030-78710-3_28

Zobrazit plný text záznamu

Effects of Fibre Orientation on Electrocardiographic and Mechanical Functions in a Computational Human Biventricular Model

Autor: Mariano Vázquez, Xin Zhou, Alfonso Santiago, Adria Quintanas, Zhinuo J. Wang, Ruben Doste, Lei Wang, Blanca Rodriguez

Publikováno v: Functional Imaging and Modeling of the Heart ISBN: 9783030787097
FIMH

The helix orientated fibres in the ventricular wall modulate the cardiac electromechanical functions. Experimental data of the helix angle through the ventricular wall have been reported from histological and image-based methods, exhibiting large var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f86ee424a2a1d157ff8f0a16b36816c
https://doi.org/10.1007/978-3-030-78710-3_34

Zobrazit plný text záznamu

Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction

Autor: Mariano Vázquez, C Kelly, Francesc Levrero-Florencio, Erica Dall’Armellina, Zhinuo J. Wang, Lei Wang, Francesca Margara, Arka Das, Blanca Rodriguez, Xin Zhou, Alfonso Santiago

Publikováno v: EP Europace
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Europace

Aims Develop, calibrate and evaluate with clinical data a human electromechanical modelling and simulation framework for multiscale, mechanistic investigations in healthy and post-myocardial infarction (MI) conditions, from ionic to clinical biomarke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb14db388f7a93fadd11cb00ed211899
https://pubmed.ncbi.nlm.nih.gov/33751088

Zobrazit plný text záznamu

Efficient estimation of load‐free left ventricular geometry and passive myocardial properties using principal component analysis

Autor: Alistair A. Young, Thiranja P. Babarenda Gamage, Zhinuo J. Wang, Vijayaraghavan Rajagopal, Martyn P. Nash, Chris P. Bradley, J Jane Cao, Vicky Y. Wang, Poul M. F. Nielsen

Publikováno v: International Journal for Numerical Methods in Biomedical Engineering. 36

Models of cardiac mechanics require a well-defined reference geometry from which deformations and hence myocardial strain and stress can be calculated. In the in vivo beating heart, the load-free (LF) geometry generally cannot be measured directly, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a02fe57f3c3ef31bd2a08ab4875e8f0
https://doi.org/10.1002/cnm.3313

Zobrazit plný text záznamu

Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant biomarkers

Autor: Mariano Vázquez, Ernesto Zacur, Alfonso Santiago, Jazmin Aguado-Sierra, Guillaume Houzeaux, Alfonso Bueno-Orovio, Francesca Margara, Francesc Levrero-Florencio, Zhinuo J. Wang, Ricardo Ruiz-Baier, Vicente Grau, Blanca Rodriguez, David Kay

Publikováno v: Computer Methods in Applied Mechanics and Engineering

The human heart beats as a result of multiscale nonlinear dynamics coupling subcellular to whole organ processes, achieving electrophysiologically-driven mechanical contraction. Computational cardiac modelling and simulation have achieved a great deg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8926f66834a9523e5769626f3205ca1e

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání