Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Zhili Rong"'
Autor:
Xiaobo Wang, Chengyuan Cai, Weiqi Lv, Kechen Chen, Jiaxin Li, Kaitong Liao, Yanqun Zhang, Hongxin Huang, Ying Lin, Zhili Rong, Xiaopin Duan
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract CRISPR-based gene therapy offers precise targeting and specific editing of disease-related gene sequences, potentially yielding long-lasting treatment effects. However, efficient delivery remains a significant challenge for its widespread ap
Externí odkaz:
https://doaj.org/article/243debc11d674ee4890ae100ab1fb676
Autor:
Xin Zhang, Xinlong Wang, Jie Lv, Hongxin Huang, Jiahong Wang, Ma Zhuo, Zhihong Tan, Guanjie Huang, Jiawei Liu, Yuchen Liu, Mengrao Li, Qixiao Lin, Lian Li, Shufeng Ma, Tao Huang, Ying Lin, Xiaoyang Zhao, Zhili Rong
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background The CRISPR/Cas12a and CRISPR/Cas13d systems are widely used for fundamental research and hold great potential for future clinical applications. However, the short half-life of guide RNAs (gRNAs), particularly free gRNAs without Ca
Externí odkaz:
https://doaj.org/article/a0460a87573647bd89dabb707e89abe6
Autor:
Tao Huang, Shijun Chen, Ke Ding, Baoqing Zheng, Weiqi Lv, Xiaobo Wang, Yadan Zhong, Hongxin Huang, Xin Zhang, Shufeng Ma, Bin Yang, Xiaohua Wang, Zhili Rong
Publikováno v:
Cell Death and Disease, Vol 14, Iss 6, Pp 1-8 (2023)
Abstract Keratinocyte hyperproliferation is a key pathogenic factor in psoriasis. However, the mechanisms that regulate keratinocyte hyperproliferation in this condition remain unclear. Here, we found that SLC35E1 was highly expressed in keratinocyte
Externí odkaz:
https://doaj.org/article/4773a7ce99174a6ba331459d2b2eb430
Autor:
Jianqi Feng, Lian Li, Zhihong Tan, Shanshan Zhao, Xin Zhang, Jinhong Wang, Yaping Ye, Ying Lin, Zhili Rong
Publikováno v:
Genes and Diseases, Vol 10, Iss 1, Pp 33-36 (2023)
Externí odkaz:
https://doaj.org/article/935f79b46cb34cf79fc92cf0f94a5e0a
Autor:
Hongxin Huang, Guanjie Huang, Zhihong Tan, Yongfei Hu, Lin Shan, Jiajian Zhou, Xin Zhang, Shufeng Ma, Weiqi Lv, Tao Huang, Yuchen Liu, Dong Wang, Xiaoyang Zhao, Ying Lin, Zhili Rong
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background The CRISPR-Cas12a (formerly Cpf1) system is a versatile gene-editing tool with properties distinct from the broadly used Cas9 system. Features such as recognition of T-rich protospacer-adjacent motif (PAM) and generation of sticky
Externí odkaz:
https://doaj.org/article/4ce248119d0b470a9127e002f177b183
Autor:
Hongxin Huang, Yongfei Hu, Guanjie Huang, Shufeng Ma, Jianqi Feng, Dong Wang, Ying Lin, Jiajian Zhou, Zhili Rong
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Hongxin Huang and Yongfei Hu et al. develop Tag-seq, a streamlined sequencing method to examine off-target editing by CRISPR-Cas systems. The authors validate Tag-seq in multiple cell lines, demonstrating its broad utility and flexibility in identify
Externí odkaz:
https://doaj.org/article/276463593c4b463886879126e4ba92c9
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2021)
Abstract Background The regulation of the transcription factor sex-determining region Y-box transcription factor 9 (SOX9) in lung development has been described in mouse, but the same principles apply to human lung development is unknown due to a lac
Externí odkaz:
https://doaj.org/article/c4eb5be75a934186ae8eb33f9fff4736
Autor:
Cheng-Cheng Deng, Yong-Fei Hu, Ding-Heng Zhu, Qing Cheng, Jing-Jing Gu, Qing-Lan Feng, Li-Xue Zhang, Ying-Ping Xu, Dong Wang, Zhili Rong, Bin Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Fibroblasts are found to be heterogeneous in multiple fibrotic diseases, but fibroblast heterogeneity in fibrotic skin diseases is not well characterized. Here the authors employ scRNA-seq to explore fibroblast heterogeneity in keloid, a paradigm of
Externí odkaz:
https://doaj.org/article/931947cadf6f42f79b721eb90ccae947
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101270- (2022)
Summary: This protocol describes how to generate lung organoids from human embryonic stem cells. Lung organoids form by self-assembly in Matrigel and contain lung epithelial cell types. The protocol presented in this study is simple and only uses 6 c
Externí odkaz:
https://doaj.org/article/884a83e3b496470999c650fbf05783cc
Autor:
Wenwen Gao, Mengqiu Huang, Xi Chen, Jianping Chen, Zhiwei Zou, Linlin Li, Kaiyuan Ji, Zhirui Nie, Bingsheng Yang, Zibo Wei, Pengfei Xu, Junshuang Jia, Qianbing Zhang, Hongfen Shen, Qianli Wang, Keyi Li, Lingqun Zhu, Meng Wang, Shuangyan Ye, Sisi Zeng, Ying Lin, Zhili Rong, Yang Xu, Peng Zhu, Hui Zhang, Bingtao Hao, Qiuzhen Liu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract One of the malignant transformation hallmarks is metabolism reprogramming, which plays a critical role in the biosynthetic needs of unchecked proliferation, abrogating cell death programs, and immunologic escape. However, the mechanism of th
Externí odkaz:
https://doaj.org/article/18e1481944334ab5bca373d996c2c4ef