Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Zhilei Chen"'
Publikováno v:
Railway Sciences, Vol 3, Iss 1, Pp 18-31 (2024)
Purpose – The electromechanical brake system is leading the latest development trend in railway braking technology. The tolerance stack-up generated during the assembly and production process catalyzes the slight geometric dimensioning and toleranc
Externí odkaz:
https://doaj.org/article/a9464b111589439ebe015b3c87e7e477
Publikováno v:
Plants, Vol 13, Iss 19, p 2743 (2024)
Anthracnose, a fungal disease harming fruit trees and crops, poses a threat to agriculture. Traditional chemical pesticides face issues like environmental pollution and resistance. A strategy combining low-toxicity chemicals with biopesticides is pro
Externí odkaz:
https://doaj.org/article/5302d2973b0d4fcba78f5afc59ce2d5e
Publikováno v:
Endocrine Connections, Vol 12, Iss 11, Pp 1-8 (2023)
Osteoporosis (OP) is a systemic bone disease in which bone density and quality decrease and bone fragility increases due to a variety of causes, making it prone to fractures. The development of OP is closely related to oxidative stress. Uric acid (UA
Externí odkaz:
https://doaj.org/article/9d0422b6d25249d7a57b51c51d608406
Publikováno v:
Bioengineering, Vol 10, Iss 12, p 1351 (2023)
Numerous potential drug targets, including G-protein-coupled receptors and ion channel proteins, reside on the cell surface as multi-pass membrane proteins. Unfortunately, despite advances in engineering technologies, engineering biologics against mu
Externí odkaz:
https://doaj.org/article/aa5d9e78b6314eb3abca7811927c5f74
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 7, p 134 (2023)
Non-alcoholic fatty liver disease (NAFLD) is a group of metabolic liver illnesses that lead to accumulation of liver fat mainly due to excessive nutrition. It is closely related to insulin resistance, obesity, type 2 diabetes, and cardiovascular dise
Externí odkaz:
https://doaj.org/article/a2546984a9d14b41a761622f3ddd0c34
Autor:
Chengmei He, Yanlei Yang, Zhilei Chen, Suying Liu, Taibiao Lyu, Liuting Zeng, Li Wang, Yongzhe Li, Mu Wang, Hua Chen, Fengchun Zhang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectivesEnhancer of zeste homolog 2 (EZH2) is an epigenetic regulator that plays an essential role in immune system development and autoimmune diseases. This study aimed to characterize the role of EZH2 in the pathogenesis of primary Sjögren’s s
Externí odkaz:
https://doaj.org/article/b6982ad0b7d64c298dd05881b959b0e1
Autor:
Mengqiu Jiang, Joonyoung Shin, Rudo Simeon, Jeng-Yih Chang, Ran Meng, Yuhang Wang, Omkar Shinde, Pingwei Li, Zhilei Chen, Junjie Zhang
Publikováno v:
PLoS Biology, Vol 20, Iss 3, p e3001589 (2022)
Clostridioides difficile secretes Toxin B (TcdB) as one of its major virulence factors, which binds to intestinal epithelial and subepithelial receptors, including frizzled proteins and chondroitin sulfate proteoglycan 4 (CSPG4). Here, we present cry
Externí odkaz:
https://doaj.org/article/9101162f017648d1a042c5adad67f2f2
Autor:
Michael Woolley, Zhilei Chen
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
In vitro protein display methods can access extensive libraries (e.g., 1012–1014) and play an increasingly important role in protein engineering. However, the preparation of large libraries remains a laborious and time-consuming process. Here we re
Externí odkaz:
https://doaj.org/article/1126b450d6c44ff8befc95769628380a
Autor:
Yu Zeng, Mengqiu Jiang, Sally Robinson, Zeyu Peng, Vikas Chonira, Rudo Simeon, Saul Tzipori, Junjie Zhang, Zhilei Chen
Publikováno v:
Bioengineering, Vol 9, Iss 10, p 511 (2022)
Shiga toxin-producing E. coli (STEC) is a common cause of bloody diarrhea. The pathology of STEC infection derives from two exotoxins—Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2)—that are secreted by STEC in the gut, from where they are systemic
Externí odkaz:
https://doaj.org/article/b1034a2f1b254f609589192793ea0f9c
Autor:
Yanlei Yang, Suying Liu, Chengmei He, Zhilei Chen, Taibiao Lyu, Liuting Zeng, Li Wang, Fengchun Zhang, Hua Chen, Robert Chunhua Zhao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Given the self-renewal, multi-differentiation, immunoregulatory, and tissue maintenance properties, mesenchymal stem cells (MSCs) are promising candidates for stem cell-based therapies. Breakthroughs have been made in uncovering MSCs as key contribut
Externí odkaz:
https://doaj.org/article/e17ab142869b43cb9d01406e3f6ec728