Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zhilan Zeng"'
Autor:
Fernando Doñate, David R. Stover, Sher Karki, Hector Aviña, Lisa Do, Josh Snyder, Veronica Robles, Zhilan Zeng, Karen Morrison, Jimmy Ou, Sathish Kumar Ganesan, Sara Gulesserian, Hui Zhao
Fig. S1. Structure of AGS-16C3F; Figure S2. ENPP3 was not expressed in megakaryocytes; Figure S3. AGS-16C3F did not affect platelet activation; Figure S4. Maturing MKs did not express ENPP3; Figure S5. Fc blocker inhibited FcγRIIA pathway in tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00342acdda45c0ff67ce6d7bb2934973
https://doi.org/10.1158/1535-7163.22509028
https://doi.org/10.1158/1535-7163.22509028
Autor:
Fernando Doñate, David R. Stover, Brian A. Mendelsohn, Michael Mattie, Zhilan Zeng, Melissa M. Williams, Mi Sook Chang, James Song, Sathish Kumar Ganesan, Maria Christina Malinao, Sara Gulesserian, Hui Zhao
Figure S1. Chemical structures of MMAF, MMAE and 13C5-MMAE. The asterisks indicate where Carbon-13 isotope has replaced Carbon-12; Figure S2. Expression of CD32 on mature neutrophils. Circulating neutrophils (AllCell) were incubated with anti-CD32 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660456dd4858e9bbebfdffd3e06f96c3
https://doi.org/10.1158/1535-7163.22508311
https://doi.org/10.1158/1535-7163.22508311
Autor:
Fernando Doñate, David R. Stover, Brian A. Mendelsohn, Roland Luethy, Sung-Ju Moon, Josh Snyder, Linnette Capo, René Hubert, Hector Aviña, Sher Karki, Pia Challita-Eid, Faisal Malik, Jeffrey Coleman, Karen Morrison, Peng Yang, Jimmy Ou, Jenny Nater, Zhilan Zeng, Sara Gulesserian, John Atkinson, Hui Zhao
AGS-16C3F is an antibody–drug conjugate (ADC) against ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) containing the mcMMAF linker-payload currently in development for treatment of metastatic renal cell carcinoma. AGS-16C3F and other ADC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15490f6d4322c9192d3919e4ad7ff9a9
https://doi.org/10.1158/0008-5472.c.6510380.v1
https://doi.org/10.1158/0008-5472.c.6510380.v1
Autor:
Fernando Doñate, David R. Stover, Brian A. Mendelsohn, Roland Luethy, Sung-Ju Moon, Josh Snyder, Linnette Capo, René Hubert, Hector Aviña, Sher Karki, Pia Challita-Eid, Faisal Malik, Jeffrey Coleman, Karen Morrison, Peng Yang, Jimmy Ou, Jenny Nater, Zhilan Zeng, Sara Gulesserian, John Atkinson, Hui Zhao
Supplemental tables 1-5: Table 1: Characteristics of peptide modified ADCs tested and IC50 in the HCEC and KU812 assays. Table 2: Characteristics. of PEG modified ADCs tested and data in the HCEC and KU812 assays. Table 3: Characteristics of mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7610130a3c9e9e7370a263155dfda9
https://doi.org/10.1158/0008-5472.22419443
https://doi.org/10.1158/0008-5472.22419443
Publikováno v:
World Journal of English Language. 12:377
In this era of globalization, pragmatic competence plays a vital role in cross-cultural communication. The objective of this study is to investigate whether location is a key factor influencing Chinese EFL undergraduates’ pragmatic competence in En
Autor:
Karen Morrison, Hector Aviña, Sathish Kumar Ganesan, Jimmy Ou, Veronica Robles, Josh Snyder, Zhilan Zeng, Hui Zhao, Sher Bahadur Karki, Fernando Donate, David R. Stover, Lisa Do, Sara Gulesserian
Publikováno v:
Molecular Cancer Therapeutics. 16:1877-1886
Thrombocytopenia is a common adverse event in cancer patients treated with antibody–drug conjugates (ADC), including AGS-16C3F, an ADC targeting ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase-3) and trastuzumab emtansine (T-DM1). This stud
Autor:
Mi Sook Chang, Fernando Donate, Michael D. Mattie, Sara Gulesserian, Melissa M. Williams, Sathish Kumar Ganesan, Zhilan Zeng, Hui Zhao, David R. Stover, Brian A. Mendelsohn, Maria-Christina Malinao, James Song
Publikováno v:
Molecular Cancer Therapeutics. 16:1866-1876
Neutropenia is a common adverse event in cancer patients treated with antibody–drug conjugates (ADC) and we aimed to elucidate the potential mechanism of this toxicity. To investigate whether ADCs affect neutrophil production from bone marrow, an i
Autor:
Pia M. Challita-Eid, Karen Morrison, Sung-Ju Moon, Rene S. Hubert, Jenny Nater, Peng Yang, Faisal Malik, Josh Snyder, Roland Luethy, Hector Aviña, Jimmy Ou, Brian A. Mendelsohn, Linnette Capo, Sher Karki, Jeffrey O. Coleman, Zhilan Zeng, Hui Zhao, Fernando Donate, Sara Gulesserian, John P. Atkinson, David R. Stover
Publikováno v:
Cancer research. 78(8)
AGS-16C3F is an antibody–drug conjugate (ADC) against ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) containing the mcMMAF linker-payload currently in development for treatment of metastatic renal cell carcinoma. AGS-16C3F and other ADC
Autor:
Meritxell Galindo Casas, Lee Mary Beth Shaughnessy, Pavel Strop, Arvind Rajpal, Zhilan Zeng, Marcella Russell, Si Wu, Christine Bee, Jaume Pons, Adela Hasa-Moreno, Dave Shelton, Davide Foletti, Amber Pham
Publikováno v:
Journal of Molecular Biology. 425:1641-1654
The emergence and spread of multi-drug-resistant strains of Staphylococcus aureus in hospitals and in the community emphasize the urgency for the development of novel therapeutic interventions. Our approach was to evaluate the potential of harnessing
Autor:
Xiaoming Yao, Ji-Fan Hu, Mark Daniels, Hadas Shiran, Xiangjun Zhou, Huifan Yan, Hongqi Lu, Zhilan Zeng, Qingxue Wang, Tao Li, Andrew R. Hoffman
Publikováno v:
Journal of Clinical Investigation. 111:265-273
IGF-II is a mitogenic peptide that has been implicated in hepatocellular oncogenesis. Since the silencing of gene expression is frequently associated with cytosine methylation at cytosine-guanine (CpG) dinucleotides, we designed a methylated oligonuc