A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

Autor: Gonzalo Hernandez-Hernandez, Samantha C O'Dwyer, Pei-Chi Yang, Collin Matsumoto, Mindy Tieu, Zhihui Fong, Timothy J Lewis, L Fernando Santana, Colleen E Clancy

Publikováno v: eLife, Vol 12 (2024)

The function of the smooth muscle cells lining the walls of mammalian systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the ‘Her

Externí odkaz: https://doaj.org/article/e1c78cfe649246afb454472a4d6e05a3

A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle.

Autor: Hernandez-Hernandez, Gonzalo, O'Dwyer, Samantha C., Pei-Chi Yang, Matsumoto, Collin, Tieu, Mindy, Zhihui Fong, Lewis, Timothy J., Santana, L. Fernando, Clancy, Colleen E.

Publikováno v: eLife; 2/9/2024, p1-30, 30p

M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors

Autor: Tuleen Alkawadri, Pei Yee Wong, Zhihui Fong, Fionnuala T Lundy, Lorcan P McGarvey, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant

Publikováno v: Alkawadri, T, Wong, P Y, Fong, Z, Lundy, F T, McGarvey, L P, Hollywood, M A, Thornbury, K D & Sergeant, G P 2022, ' M2 muscarinic receptor-dependent contractions of airway smooth muscle are inhibited by activation of β-adrenoceptors ', Function, vol. 3, no. 6, zqac050 . https://doi.org/10.1093/function/zqac050

Beta-adrenoceptor (β-AR) agonists inhibit cholinergic contractions of airway smooth muscle (ASM), but the underlying mechanisms are unclear. ASM cells express M3 and M2 muscarinic receptors, but the bronchoconstrictor effects of acetylcholine are be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c77a792a818bebeb682c8c1caf55fa0
https://pubmed.ncbi.nlm.nih.gov/36325515

β3-Adrenoceptor agonists inhibit purinergic receptor-mediated contractions of the murine detrusor

Autor: Zhihui Fong, Caoimhin S. Griffin, Gerard P. Sergeant, Keith D. Thornbury, Mark A. Hollywood

Publikováno v: American Journal of Physiology-Cell Physiology. 317:C131-C142

β3-Adrenoceptor (β3-AR) agonists are used to treat overactive bladder syndrome; however, their mechanism of action has not been determined. The aims of this study were to compare the effects of β3-AR agonists on cholinergic versus purinergic recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c2aa08961c44881537c1c039537cbe0
https://doi.org/10.1152/ajpcell.00488.2018

Regulation of P2X1 receptors by modulators of the cAMP effectors PKA and EPAC.

Autor: Zhihui Fong, Griffin, Caoimhín S., Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., Sergeant, Gerard P.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 9/14/2021, Vol. 118 Issue 37, p1-7, 7p