Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Zhiheng Yu"'
Autor:
Congcong Liu, Yunde Dou, Mengge Zhang, Shan Han, Shourui Hu, Yuxuan Li, Zhiheng Yu, Yue Liu, Xiaofan Liang, Zi-Jiang Chen, Han Zhao, Yuqing Zhang
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Excessive energy intake in modern society has led to an epidemic surge in metabolic diseases, such as obesity and type 2 diabetes, posing profound threats to women’s reproductive health. However, the precise impact and underlyin
Externí odkaz:
https://doaj.org/article/f3aef4f4e39b4dc0b945809f0ef29e8f
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Aims: Cetirizine is frequently administered at an increased dosage in clinical practice and recommended by several guidelines. Nonetheless, the pharmacokinetic (PK) profile and real-world safety data remain insufficient in the Chinese pediatric popul
Externí odkaz:
https://doaj.org/article/fdc4832bb7734b97b3377f74cc67d15d
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Small unilamellar vesicles (SUVs) are indispensable model membranes, organelle mimics, and drug and vaccine carriers. However, the lack of robust techniques to functionalize or organize preformed SUVs limits their applications. Here we use D
Externí odkaz:
https://doaj.org/article/2a26b606c37d4004bc1771b425a2385c
Autor:
Katharine M. Wright, Sarah R. DiNapoli, Michelle S. Miller, P. Aitana Azurmendi, Xiaowei Zhao, Zhiheng Yu, Mayukh Chakrabarti, WuXian Shi, Jacqueline Douglass, Michael S. Hwang, Emily Han-Chung Hsiue, Brian J. Mog, Alexander H. Pearlman, Suman Paul, Maximilian F. Konig, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B. Gabelli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Specificity remains a major challenge to current therapeutic strategies for cancer. Mutation associated neoantigens (MANAs) are products of genetic alterations, making them highly specific therapeutic targets. MANAs are HLA-presented (pHLA)
Externí odkaz:
https://doaj.org/article/5c61b5ab3e274b5e8cb75d96c8090383
Autor:
Wei Jiang, Jijun Feng, Shuo Yuan, Haipeng Liu, Zhiheng Yu, Cunliang Yang, Wenbo Ren, Xincheng Xia, Zhengjie Wang, Fengli Huang
Publikováno v:
Micromachines, Vol 15, Iss 6, p 666 (2024)
In this work, phase-apodized silicon grating filters with varying sidewall corrugation width and location were investigated, while the resonance wavelength, extinction ratio, and rejection bandwidth were tuned flexibly. The grating filters with a wav
Externí odkaz:
https://doaj.org/article/2ca29a39a95d48b8b7fd6a1de5946640
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 467-477 (2023)
Abstract The objective of this study was to determine the potential usefulness of an animal model to predict the appropriate dose of newly developed drugs for treating relapsing remitting multiple sclerosis (RRMS). Conversion of the lowest effective
Externí odkaz:
https://doaj.org/article/bdfdc6f7b02d4bb6a5e639386d7e3251
Autor:
Alexandria N Miller, Patrick R Houlihan, Ella Matamala, Deny Cabezas-Bratesco, Gi Young Lee, Ben Cristofori-Armstrong, Tanya L Dilan, Silvia Sanchez-Martinez, Doreen Matthies, Rui Yan, Zhiheng Yu, Dejian Ren, Sebastian E Brauchi, David E Clapham
Publikováno v:
eLife, Vol 12 (2023)
The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic pathway, and Golgi apparatus. Some reports have led to annotation of both Or
Externí odkaz:
https://doaj.org/article/7aea50eabcf9434b9dd126c619c9efbc
Autor:
Zhiheng Yu, Zihan Lei, Xueting Yao, Hengbang Wang, Miao Zhang, Zhe Hou, Yafen Li, Yangyu Zhao, Haiyan Li, Dongyang Liu, Yifan Zhai
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Olverembatinib (HQP1351) is a third-generation BCR-ABL tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia (CML) (including T315I-mutant disease), exhibits drug-drug interaction (DDI) potential through cytochrome P450 (CYP) enzyme
Externí odkaz:
https://doaj.org/article/e057d585033c46888bfd0927e6e519e0
Publikováno v:
AIP Advances, Vol 12, Iss 10, Pp 105205-105205-10 (2022)
Microstructure plays an important role in improving the performance of flexible sensors. Changing the shape of the dielectric layer microstructure is an effective countermeasure to promote the sensitivity of capacitive sensors. Nevertheless, traditio
Externí odkaz:
https://doaj.org/article/d754cd85b56f4c8bac3890e71802c0d8
Autor:
Miao Zhang, Zhiheng Yu, Xueting Yao, Zihan Lei, Kaijing Zhao, Wenqian Wang, Xue Zhang, Xijing Chen, Dongyang Liu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Pyrotinib, a novel irreversible epidermal growth factor receptor dual tyrosine kinase inhibitor, is mainly (about 90%) eliminated through cytochrome P450 (CYP) 3A mediated metabolism in vivo. Meanwhile, genotype is a key factor affecting pyrotinib cl
Externí odkaz:
https://doaj.org/article/be6fa8d0ddde4b4daa35e428b0069e02