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Akademický článek

Basic Fibroblast Growth Factor Attenuates Injury in Myocardial Infarction by Enhancing Hypoxia-Inducible Factor-1 Alpha Accumulation

Autor: Zhiheng Rao, Danping Shen, Jiahui Chen, Lushen Jin, Xueping Wu, Ming Chen, Lei Li, Maoping Chu, Jiafeng Lin

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

BackgroundThe combination of antiapoptotic and angiogenic actions may represent a pharmacotherapeutic strategy for the treatment of myocardial infarction. Fibroblast growth factor (FGF) is expressed in various cell types including endothelial and mus

Externí odkaz: https://doaj.org/article/40b052e1e91a4e248b460e40f34587f2

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FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3β-Mediated Stabilization of Slug

Autor: Jian Sun, Jie Zhou, Jianhui Zhou, Wenxin Xu, Yali Du, Zhenyu Jia, Yingjie Shen, Xiaohua Lin, Xulan Wang, Yuxuan Bao, Zhiheng Rao, Siyang Dong, Yongde Luo, Weitao Cong, Litai Jin, Xiaokun Li

Publikováno v: The Journal of investigative dermatology.

Cutaneous wound healing is an orderly and intricate process that restores the barrier function and integrity of injured skin. Re-epithelialization, which involves the proliferation and migration of keratinocytes to cover the denuded surface, is essen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0cabd4f3af3d56d2f38357b6bd2b1b
https://pubmed.ncbi.nlm.nih.gov/36521556

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FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis

Publikováno v: Hepatology (Baltimore, Md.)REFERENCES. 76(4)

NAFLD represents an increasing health problem in association with obesity and diabetes with no effective pharmacotherapies. Growing evidence suggests that several FGFs play important roles in diverse aspects of liver pathophysiology. Here, we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efc9df60ef3e57f52535aa3d9dc76f3
https://pubmed.ncbi.nlm.nih.gov/35278237

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Roles of the fibroblast growth factor signal transduction system in tissue injury repair

Autor: Keyang Chen, Zhiheng Rao, Siyang Dong, Yajing Chen, Xulan Wang, Yongde Luo, Fanghua Gong, Xiaokun Li

Publikováno v: Burnstrauma. 10

Following injury, tissue autonomously initiates a complex repair process, resulting in either partial recovery or regeneration of tissue architecture and function in most organisms. Both the repair and regeneration processes are highly coordinated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74be62591bff757ebb8fd8169cb5fac
https://pubmed.ncbi.nlm.nih.gov/35350443

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Sulodexide attenuates endoplasmic reticulum stress induced by myocardial ischaemia/reperfusion by activating the PI3K/Akt pathway

Autor: Maoping Chu, Yongxue Ruan, Ruiyao Chen, Lei Li, Zhiheng Rao, Danping Shen, Yuanhai Zhang, Lijing Zhang

Publikováno v: Journal of Cellular and Molecular Medicine

Acute myocardial ischaemia/reperfusion (MI/R) injury causes severe arrhythmias with a high rate of lethality. Extensive research focus on endoplasmic reticulum (ER) stress and its dysfunction which leads to cardiac injury in MI/R Our study evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b551cd5a79cba486ba9b53b946cfa9
https://doi.org/10.1111/jcmm.14367

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Dexmedetomidine Exerted Anti-arrhythmic Effects in Rat With Ischemic Cardiomyopathy via Upregulation of Connexin 43 and Reduction of Fibrosis and Inflammation

Autor: Zhiheng Rao, Lei Li, Jia-Feng Lin, Yuan-Zheng Lin, Shu‐Jie Wu, Zhong‐Hao Lin, Lianpin Wu

Publikováno v: Frontiers in Physiology, Vol 11 (2020)
Frontiers in Physiology

Background---Persistent myocardial ischemia occurred in post-myocardial infarction could lead to fatal ventricular arrhythmias like ventricular tachycardia and fibrillation and also has high rate of mortality. Dexmedetomidine (Dex), a highly selectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d20044f47229108b1cc3eaec80d85a

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A20 functions as mediator in TNFα-induced injury of human umbilical vein endothelial cells through TAK1-dependent MAPK/eNOS pathway

Autor: Zhiheng Rao, Jiafeng Lin, Shi-Yang Song, Qike Jin, Maoping Chu, Rongzhou Wu, Bingqing Huang, Lei Li, Hareshwaree Sohun, Jingjing Zeng, Kangting Ji, Lianpin Wu, Luyuan Tao

Publikováno v: Oncotarget

A20, a negative regulator of nuclear factor κB signaling, has been shown to attenuate atherosclerotic events. Transforming growth factor beta-activated kinase 1 (TAK1) plays a critical role in TNFα-induced atherosclerosis via endothelial nitric oxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb29d5269c19f3a6a827e3ea97a089ef
https://doi.org/10.18632/oncotarget.18191

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Alteration of Cholinergic Anti‐Inflammatory Pathway in Rat With Ischemic Cardiomyopathy–Modified Electrophysiological Function of Heart

Autor: Lei Li, Maoping Chu, Zhe‐Wei Shi, Jiafeng Lin, Shu‐Jie Wu, Zhong‐Hao Lin, Yue‐Chun Li, Zhiheng Rao, Si‐Chao Tai

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background With chronic ischemia after myocardial infarction, the resulting scar tissue result in electrical and structural remodeling vulnerable to an arrhythmogenic substrate. The cholinergic anti‐inflammatory pathway elicited by vagal nerve via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e4591eed99d4ade26fc9a054e8f3c0
http://europepmc.org/articles/PMC5634297

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