Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Zhiguo J, Song"'
Autor:
Zhiguo J. Song
Publikováno v:
Organic Syntheses. 99:251-273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::424d155efdfd9e8ba004008a796016cf
https://doi.org/10.15227/orgsyn.099.0251
https://doi.org/10.15227/orgsyn.099.0251
Autor:
Stephen M. Dalby, Louis-Charles Campeau, Bryon Simmons, Tyler A. Davis, Amude M. Kassim, Timothy J. Wright, Ralph Calabria, Zhiguo J. Song, Cyndi Qixin He, John Limanto, John Y. L. Chung
Publikováno v:
Organic Process Research & Development. 26:698-709
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acaf361c14adf7ecc1b65e7423f440f6
https://doi.org/10.1021/acs.oprd.1c00175
https://doi.org/10.1021/acs.oprd.1c00175
Publikováno v:
Organic Process Research & Development. 25:82-88
Two efficient synthetic methods for preparation of 3-(trifluoromethyl)cyclobutane-1-carboxylic acid are reported starting from readily available 4-oxocyclobutane precursors. These cyclobutanones ca...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b940b01b83f1c7646fd72cd2a45d5093
https://doi.org/10.1021/acs.oprd.0c00422
https://doi.org/10.1021/acs.oprd.0c00422
Autor:
Derun Li, David L. Sloman, Abdelghani Achab, Hua Zhou, Meredeth A. McGowan, Catherine White, Craig Gibeau, Hongjun Zhang, Qinglin Pu, Indu Bharathan, Brett Hopkins, Kun Liu, Heidi Ferguson, Xavier Fradera, Charles A. Lesburg, Theodore A. Martinot, Ji Qi, Zhiguo J. Song, Jingjun Yin, Huangguang Zhang, Licheng Song, Baoqiang Wan, Suzanne DAddio, Nicolas Solban, J. Richard Miller, Beata Zamlynny, Alan Bass, Elizabeth Freeland, Bridget Ykoruk, Catherine Hilliard, Jude Ferraro, Jin Zhai, Ian Knemeyer, Karin M. Otte, Stella Vincent, Nunzio Sciammetta, Alexander Pasternak, David Jonathan Bennett, Yongxin Han
Publikováno v:
Journal of medicinal chemistry. 65(8)
3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable for Q3W (once every 3 weeks) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65de888aa90fb7088ca022d5b5ddf12
https://pubmed.ncbi.nlm.nih.gov/35239336
https://pubmed.ncbi.nlm.nih.gov/35239336
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f69fcd69d6249d32285e727067610d
https://doi.org/10.2139/ssrn.4187024
https://doi.org/10.2139/ssrn.4187024
Autor:
Josep Saurí, Michael J. Ardolino, Zhiguo J. Song, Lu Chen, Daniel J. Muzzio, Lushi Tan, Thomas Vickery, Jingjun Yin, Ji Qi, Chaomin Li, Yu-hong Lam, Ralph Zhao, Theodore A. Martinot, Matthew L. Maddess
Publikováno v:
Organic Process Research & Development. 23:1178-1190
The development of a stereospecific synthesis of a IDO1-selective inhibitor is described. The synthetic strategy toward enabling early discovery efforts along with additional findings pertaining to...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa9f7077763e03ea8e46e168c12e2d5
https://doi.org/10.1021/acs.oprd.9b00105
https://doi.org/10.1021/acs.oprd.9b00105
Autor:
Donovon A. Adpressa, Richmond Sarpong, Charles S. Yeung, Michaelyn C. Lux, Jin Su Ham, Yu-hong Lam, Zhiguo J. Song, Chao Ma, Justin Jurczyk, Nunzio Sciammetta, Jose B. Roque
Publikováno v:
Organic letters, vol 22, iss 16
The construction of complex aza-cycles is of interest to drug discovery due to the prevalence of nitrogen-containing heterocycles in pharmaceutical agents. Herein we report an intramolecular C-H amination approach to afford value-added and complexity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a03b1ea073ed69254c6831f682340bd
https://pubmed.ncbi.nlm.nih.gov/32806157
https://pubmed.ncbi.nlm.nih.gov/32806157
Publikováno v:
Organic Process Research & Development. 22:1257-1261
A practical, safe, and scalable synthesis of the stable nitro-oxide radical catalyst ABNO was developed. This process is chromatography-free and avoids the Wolff–Kishner reduction. 1H NMR data for this paramagnetic compound were obtained that allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4e493b5750e33b140e6d49fe52d773d
https://doi.org/10.1021/acs.oprd.8b00191
https://doi.org/10.1021/acs.oprd.8b00191
Autor:
Jacob H. Waldman, Thomas W. Lyons, Lu Chen, John R. Naber, Wenyong Chen, David A. Thaisrivongs, Baoyun Zhang, Zhiguo J. Song, Lushi Tan, William J. Morris, Jun Yang
Publikováno v:
Organic Letters. 20:1568-1571
The development of a commercial manufacturing route to verubecestat (MK-8931) is described, highlights of which include the application of a continuous processing step to outcompete fast proton transfer in a Mannich-type ketimine addition, a copper-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530acab271d12a421b5eb366ed2ce2bb
https://doi.org/10.1021/acs.orglett.8b00259
https://doi.org/10.1021/acs.orglett.8b00259
Autor:
Feng Xu, Matthew D. Truppo, Hongming Li, Zhiguo J. Song, Yong-Li Zhong, Rebecca T. Ruck, Richard Desmond, Ji Qi, Tao Wang, Guy R. Humphrey, Jeonghan Park
Publikováno v:
Organic Letters. 19:5880-5883
A practical and asymmetric synthesis of a functionalized trans-cyclopropoxy building block for the preparation of the HCV NS3/4a protease inhibitor grazoprevir is reported. Intramolecular SN2 displacement–ring closure, followed by a Baeyer–Villig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd55ddc85520b4863b2892a5d3b0bc30
https://doi.org/10.1021/acs.orglett.7b02867
https://doi.org/10.1021/acs.orglett.7b02867