Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Zhiguang Jia"'
Autor:
Guohui Zhang, Xianjin Xu, Zhiguang Jia, Yanyan Geng, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Karl L. Magleby, Jonathan R. Silva, Jianhan Chen, Xiaoqin Zou, Jianmin Cui
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Ca2+ activated BK channels are important for neural and muscle function. Here authors use a compound, BC5, to show that the interface between the cytosolic and voltage sensing domains is a major allosteric pathway for Ca2+ binding to open the channel
Externí odkaz:
https://doaj.org/article/67b10c912c5146eda08534fccfe9cc8f
Autor:
Erik Nordquist, Guohui Zhang, Shrishti Barethiya, Nathan Ji, Kelli M White, Lu Han, Zhiguang Jia, Jingyi Shi, Jianmin Cui, Jianhan Chen
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1011460 (2023)
Machine learning has played transformative roles in numerous chemical and biophysical problems such as protein folding where large amount of data exists. Nonetheless, many important problems remain challenging for data-driven machine learning approac
Externí odkaz:
https://doaj.org/article/df1b3ec8b0da420e9040b66a6deabfa8
Autor:
Zhiguang Jia, Jianhan Chen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Chen and Jia investigate the synergistic regulating role of Ca2 + binding and the signaling lipid PIP2 in TMEM16A channel gating. Their study is significant as it provides new insights into the activated state of TMEM16A and highlights an example of
Externí odkaz:
https://doaj.org/article/bf4f8b3a1dbc4a51bb8c8b7646a0653c
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability and muscle contraction. Here authors show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desen
Externí odkaz:
https://doaj.org/article/7a7fbea43b5a481ab048b4ad58174d2f
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
TMEM16F is an enigmatic Ca2 + -activated phospholipid scramblase (CaPLSase) that passively transports phospholipids. Here authors identify an inner activation gate and its disruption profoundly alters TMEM16F phospholipid permeation.
Externí odkaz:
https://doaj.org/article/ff04ecc72037485988bec5dbf32407c6
Publikováno v:
eLife, Vol 9 (2020)
Large-conductance potassium (BK) channels are transmembrane (TM) proteins that can be synergistically and independently activated by membrane voltage and intracellular Ca2+. The only covalent connection between the cytosolic Ca2+ sensing domain and t
Externí odkaz:
https://doaj.org/article/d87b165afc6d4c58a93396ae36c60b70
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
BK channels are regulated by membrane voltage and intracellular Ca2+ but the structural features that block the ion flow in the closed state remain unknown. Here authors use molecular dynamics simulation and show that a physical gate is not required;
Externí odkaz:
https://doaj.org/article/780a4ba56ad34fc58c8da32e6b0a5109
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/b6d60071949042379c3757ca3aa56f91
Publikováno v:
Biophysical Journal. 122:1158-1167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab212131c67c7462a0e949035cd1072
https://doi.org/10.1016/j.bpj.2023.02.005
https://doi.org/10.1016/j.bpj.2023.02.005
Publikováno v:
Biophysical Journal. 121:3445-3457
Transmembrane protein 16F (TMEM16F) is a ubiquitously expressed Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552f2ec17b2a65be8692dcc6ee5e72ab
https://doi.org/10.1016/j.bpj.2022.08.011
https://doi.org/10.1016/j.bpj.2022.08.011