Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Zhigang, Lyu"'
Autor:
Md Shafiqul Islam, Samuel L. Junod, Si Zhang, Zakey Yusuf Buuh, Yifu Guan, Mi Zhao, Kishan H. Kaneria, Parmila Kafley, Carson Cohen, Robert Maloney, Zhigang Lyu, Vincent A. Voelz, Weidong Yang, Rongsheng E. Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Strategies capable of stapling unprotected peptides in a straightforward, chemoselective, and clean manner, as well as promoting cellular uptake are of great interest. Here the authors report a peptide macrocyclization and stapling strategy which sat
Externí odkaz:
https://doaj.org/article/f87430b3787e42cbbe8ea65567d72d8b
Publikováno v:
Xibei Gongye Daxue Xuebao/Journal of Northwestern Polytechnical University. 39:1356-1367
Small data sets make the statistical information in Bayesian network parameter learning inaccurate, which makes it difficult to get accurate Bayesian network parameters based on data. Qualitative maximum a posteriori estimation (QMAP) is the most acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13801238e0e2b734ca19d4ea53500340
https://doi.org/10.1051/jnwpu/20213961356
https://doi.org/10.1051/jnwpu/20213961356
Autor:
Yue Zhao, Mi Zhao, Zhigang Lyu, Nicole Gorman, Todd R. Lewis, Aaron R. Goldman, Hsin-Yao Tang, Rongsheng E. Wang
Global detection and identification of protein post-translational modification (PTM) is a major bottleneck due to its dynamic property and rather low abundance. Tremendous efforts have been since made to develop antibody-based immunoaffinity enrichme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f89ea7f5a01b68e522ecd26ab54fc75
https://doi.org/10.1101/2022.09.13.507737
https://doi.org/10.1101/2022.09.13.507737
Autor:
Zakey Yusuf Buuh, Nicole Gorman, Hsin-Yao Tang, Zhigang Lyu, Aaron R. Goldman, Yue Zhao, Rongsheng E. Wang, Shafiqul Islam
Publikováno v:
J Am Chem Soc
We have developed a novel bioorthogonal reaction that can selectively displace fluorine substitutions alpha to amide bonds. This fluorine–thiol displacement reaction (FTDR) allows for fluorinated cofactors or precursors to be utilized as chemical r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d9e8b4916effd0b37dc679ede3c0f7
https://doi.org/10.1021/jacs.0c05605
https://doi.org/10.1021/jacs.0c05605
Autor:
Shafiqul Islam, Nicole Gorman, Yue Zhao, Hsin-Yao Tang, Zakey Yusuf Buuh, Zhigang Lyu, Rongsheng E. Wang, Aaron R. Goldman
We have developed a novel bioorthogonal reaction that can selectively displace fluorine substitutions alpha to amide bonds. This fluorine-thiol displacement reaction (FTDR) allows for fluorinated cofactors or precursors to be utilized as chemical rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcb4087502471f96dce47e86ac307286
https://doi.org/10.1101/2020.09.09.290221
https://doi.org/10.1101/2020.09.09.290221
Autor:
Zakey Yusuf Buuh, Vincent A. Voelz, Y. Guan, Weidong Yang, K. H. Kaneria, Zhigang Lyu, Samuel L. Junod, Rongsheng E. Wang, M. S. Islam, Si Zhang
Stapled peptides serve as a powerful tool for probing protein-protein interactions, but its application has been largely impeded by the limited cellular uptake. Here we report the discovery of a facile peptide macrocyclization and stapling strategy b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::823c37be17e2f9c8f4046e9dc964f0de
https://doi.org/10.1101/2020.09.09.290379
https://doi.org/10.1101/2020.09.09.290379
Autor:
Dawei Jiang, Jeffrey C. McGuth, Lei Kang, Haley L. Wissler, Weibo Cai, Zhigang Lyu, Juanjuan Du, Zakey Yusuf Buuh, Rongsheng E. Wang
Publikováno v:
ACS Chemical Biology. 13:958-964
Genetic incorporation of unnatural amino acids (UAAs) provides a unique approach to the synthesis of site-specific antibody conjugates that are homogeneous and better defined constructs than random conjugates. Yet, the yield varies for every antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6457e5f0d174c3fe15a2101b2820aa
https://doi.org/10.1021/acschembio.8b00107
https://doi.org/10.1021/acschembio.8b00107
Publikováno v:
Journal of Medicinal Chemistry. 61:3239-3252
Post-translational modifications (PTMs) allot versatility to the biological functions of highly conserved proteins. Recently, modifications to non-histone proteins such as methylation, acetylation, phosphorylation, glycosylation, ubiquitination, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd3e04683b5341a549f5298ab50d3806
https://doi.org/10.1021/acs.jmedchem.6b01817
https://doi.org/10.1021/acs.jmedchem.6b01817
Autor:
Emily B. Ehlerding, Haley L. Wissler, Zakey Yusuf Buuh, Si Zhang, Rongsheng E. Wang, Jeffrey C. McGuth, Yue Zhao, Weibo Cai, Anisa R. Eshraghi, Jonathan W. Engle, Zhigang Lyu, Yifu Guan, Vincent A. Voelz, Sarah J Bartlett
Publikováno v:
Mol Pharm
The rapid ascension of immune checkpoint blockade treatments has placed an emphasis on the need for viable, robust, and noninvasive imaging methods for immune checkpoint proteins, which could be of diagnostic value. Immunoconjugate-based positron emi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44345f7100595f684d7cde8629e0194b
https://pubmed.ncbi.nlm.nih.gov/30875232
https://pubmed.ncbi.nlm.nih.gov/30875232
Publikováno v:
Journal of medicinal chemistry. 61(8)
Post-translational modifications (PTMs) allot versatility to the biological functions of highly conserved proteins. Recently, modifications to non-histone proteins such as methylation, acetylation, phosphorylation, glycosylation, ubiquitination, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e9d8e49235c4c00613e1f990ba614f0
https://pubmed.ncbi.nlm.nih.gov/28505447
https://pubmed.ncbi.nlm.nih.gov/28505447