Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Zhibing Zheng"'
Autor:
Pengyun Li, Xiaotong Hu, Zhiya Fan, Shiyang Sun, Qijie Ran, Ting Wei, Pengli Wei, Qiyu Jiang, Jian Yan, Ning Yang, Changkai Jia, Tingting Yang, Yaqiu Mao, Xu Cai, Tingting Xu, Zhiyuan Zhao, Xiaohong Qian, Weijie Qin, Xiaomei Zhuang, Feng Fan, Junhai Xiao, Zhibing Zheng, Song Li
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-30 (2024)
Abstract Background Targeted protein degradation of neosubstrates plays a crucial role in hematological cancer treatment involving immunomodulatory imide drugs (IMiDs) therapy. Nevertheless, the persistence of inevitable drug resistance and hematolog
Externí odkaz:
https://doaj.org/article/53485170677d439b9bf56471960e9a2e
Autor:
Pengyun Li, Changkai Jia, Zhiya Fan, Xiaotong Hu, Wenjuan Zhang, Ke Liu, Shiyang Sun, Haoxin Guo, Ning Yang, Maoxiang Zhu, Xiaomei Zhuang, Junhai Xiao, Zhibing Zheng, Song Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2715-2735 (2023)
Various c-mesenchymal-to-epithelial transition (c-MET) inhibitors are effective in the treatment of non-small cell lung cancer; however, the inevitable drug resistance remains a challenge, limiting their clinical efficacy. Therefore, novel strategies
Externí odkaz:
https://doaj.org/article/a6801985536042d3a2e104c93c866c0d
Autor:
Pengyun Li, Qiaohong Lin, Shiyang Sun, Ning Yang, Yu Xia, Shengjie Cao, Wenjuan Zhang, Qian Li, Haoxin Guo, Maoxiang Zhu, Yilong Wang, Zhibing Zheng, Song Li
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-15 (2022)
Abstract Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that displays highly aggressive with poor prognosis. Owing to the limited targets and drugs for TNBC clinical therapy, it is necessary to investigate the factor
Externí odkaz:
https://doaj.org/article/a8a29faa6b9f4752871e26be33e9dd49
Autor:
Shiyang Sun, Pengyun Li, Jiaqi Wang, Dongsheng Zhao, Tingting Yang, Peilan Zhou, Ruibin Su, Zhibing Zheng, Song Li
Publikováno v:
Molecules, Vol 29, Iss 5, p 1097 (2024)
The α2A adrenergic receptor (α2A-AR) serves as a critical molecular target for sedatives and analgesics. However, α2A-AR ligands with an imidazole ring also interact with an imidazoline receptor as well as other proteins and lead to undesirable ef
Externí odkaz:
https://doaj.org/article/8b62ccdde7fd4284b56ce4b3cee1fab5
Autor:
Pengyun Li, Shengjie Cao, Yubing Huang, Yanan Zhang, Jie Liu, Xu Cai, Lulu Zhou, Jianbin Li, Zefei Jiang, Lihua Ding, Zhibing Zheng, Song Li, Qinong Ye
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Increasing evidence suggests the pivotal role of hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) in cancer development and progression, indicating that HPIP inhibition may be a promising target
Externí odkaz:
https://doaj.org/article/7915f9e9a46e40ef86dc654dbe8d6fce
Autor:
Si Qin, Zhilan He, Yuanjie Wu, Chaoxi Zeng, Zhibing Zheng, Haowei Zhang, Chenghao Lv, Yong Yuan, Haoren Wu, Jianhui Ye, Zhonghua Liu, Meng Shi
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Instant dark tea (IDT) is a new product gaining increasing attention because it is convenient and can endow significant health benefit to consumers, which is partially attributed to its high concentration of functional ingredients. However, the molec
Externí odkaz:
https://doaj.org/article/c6be122baf6340d6ac0af653f71e5127
Autor:
Yahan Zhang, Mengke Ma, Longming Chen, Xinbei Du, Zhao Meng, Han Zhang, Zhibing Zheng, Junyi Chen, Qingbin Meng
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2621 (2022)
Advanced external preparations that possess a sustained-release effect and integrate few irritant elements are urgently needed to satisfy the special requirements of topical administration in the clinic. Here, a series of liquid pillar[n]arene-bearin
Externí odkaz:
https://doaj.org/article/c3a21886738d40e1a93bcb99a85189a9
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Crocetin is a carotenoid extracted from Gardenia jasminoides, one of the most popular traditional Chinese medicines, which has been used in the prevention and treatment of various diseases. The present study is aimed at clarifying the effect of croce
Externí odkaz:
https://doaj.org/article/2ff51f6f189d48ddbe24568320217d55
Autor:
Liang Chen, Meng Shi, Chenghao Lv, Ying Song, Yuanjie Wu, Suifei Liu, Zhibing Zheng, Xiangyang Lu, Si Qin
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Dihydromyricetin (DHM) is a flavonoid extracted from the leaves and stems of the edible plant Ampelopsis grossedentata that has been used for Chinese Traditional Medicine. It has attracted considerable attention from consumers due to its beneficial p
Externí odkaz:
https://doaj.org/article/66d7bfd7719f4482b9551ad0fb45119c
Publikováno v:
Molecules, Vol 27, Iss 3, p 1096 (2022)
A family of novel efficient non-oxime compounds exhibited promising reactivation efficacy for VX and sarin inhibited human acetylcholinesterase was discovered. It was found that aromatic groups coupled to Mannich phenols and the introduction of imida
Externí odkaz:
https://doaj.org/article/aeb2384e871c48acb939ad2483fa1ada