Zobrazeno 1 - 10
of 152
pro vyhledávání: '"ZhiFang Dong"'
Autor:
Man Luo, Yayan Pang, Junjie Li, Lilin Yi, Bin Wu, Qiuyun Tian, Yan He, Maoju Wang, Lei Xia, Guiqiong He, Weihong Song, Yehong Du, Zhifang Dong
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 635-652 (2024)
Alzheimer's disease (AD) is a leading cause of dementia in the elderly. Mitogen-activated protein kinase phosphatase 1 (MKP-1) plays a neuroprotective role in AD. However, the molecular mechanisms underlying the effects of MKP-1 on AD have not been e
Externí odkaz:
https://doaj.org/article/3c74df04a92a4e7c9d31b5922b70dbad
Autor:
Min Wang, Yixue Gu, Qiubo Li, Bangzhe Feng, Xinke Lv, Hao Zhang, Qingxia Kong, Zhifang Dong, Xin Tian, Yanke Zhang
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 100997- (2024)
Epilepsy, one of the most common neurological disorders, is characterized by spontaneous recurrent seizures. Temporal lobe epilepsy (TLE) is one of the most common medically intractable seizure disorders. Traf2-and NcK-interacting kinase (TNIK) has r
Externí odkaz:
https://doaj.org/article/1e4afd6b6fde403e9230c64ff982f95b
Autor:
Yuxin Chen, Xiaohuan Li, Qian Xiong, Yehong Du, Man Luo, Lilin Yi, Yayan Pang, Xiuyu Shi, Yu Tian Wang, Zhifang Dong
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background The nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is believed to be a key mediator of neuroinflammation and subsequent secondary brain injury induced by ischemic stroke. However, the role
Externí odkaz:
https://doaj.org/article/84d1f759cb4d4ccbbf6c8f9e1023baa1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Alzheimer’s disease (AD) is a debilitating, progressive, neurodegenerative disorder characterized by the deposition of amyloid-β (Aβ) peptides and subsequent oxidative stress, resulting in a cascade of cytotoxic effects. Fangchinoli
Externí odkaz:
https://doaj.org/article/a8ad2ff6f61041a4a89315421b0b9f0c
Publikováno v:
Genes and Diseases, Vol 10, Iss 3, Pp 1062-1074 (2023)
Disrupting the balance of neuronal excitation and inhibition (E/I) is an important pathogenic mechanism of anxiety and depression. Interferon regulatory factor 3 (IRF3) plays a key role in the innate immune response, and activation of IRF3 triggers t
Externí odkaz:
https://doaj.org/article/fce1e2e1e34248098b086920592da72e
Autor:
Ke Cheng, Yue Wang, Yong He, Yu Tian, Junjie Li, Chong Chen, Xingzhe Xu, Zhonghao Wu, Heming Yu, Xiangyu Chen, Yili Wu, Weihong Song, Zhifang Dong, Huatai Xu, Peng Xie
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Carbonic Anhydrase 1 (CAR1) is a zinc-metalloenzyme that catalyzes the hydration of carbon dioxide, and the alteration of CAR1 has been implicated in neuropsychiatric disorders. However, the mechanism underlying the role of CAR1 in major dep
Externí odkaz:
https://doaj.org/article/40779fbd53c7457dadf7693a13944c94
Autor:
Yan Yan, Da Song, Yue Jin, Yujun Deng, Chunjian Wang, Tao Huang, Yuanhong Tang, Yu Yang, Yun Zhang, Zhe Wang, Zhifang Dong, Yuetian Wang, Juan Zhao, Junjun Ni, Hui Li, Jun Zhang, Yiran Lang, Yili Wu, Hong Qing, Zhenzhen Quan
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Animals need discriminating auditory fear memory (DAFM) to survive, but the related neural circuits of DAFM remain largely unknown. Our study shows that DAFM depends on acetylcholine (ACh) signal in the auditory cortex (ACx), which is projec
Externí odkaz:
https://doaj.org/article/cf84139c4aea44f2841dbf16a2eefcba
Autor:
Ya Wen, Zhifang Dong, Jun Liu, Peter Axerio-Cilies, Yehong Du, Junjie Li, Long Chen, Lu Zhang, Lidong Liu, Jie Lu, Ning Zhou, Dong Chuan Wu, Yu Tian Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-18 (2022)
Abstract Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor (GABAAR) mediated inhibition is essential for brain functioning; and its imbalance contributes to the pathogenesis of ma
Externí odkaz:
https://doaj.org/article/133ea9a75bc840049467928b191b5e7f
Autor:
Yehong Du, Junjie Li, Maoju Wang, Qiuyun Tian, Yayan Pang, Ya Wen, Dongchuan Wu, Yu Tian Wang, Zhifang Dong
Publikováno v:
MedComm, Vol 4, Iss 3, Pp n/a-n/a (2023)
Abstract The imbalance between neuronal excitation and inhibition (E/I) in neural circuit has been considered to be at the root of numerous brain disorders. We recently reported a novel feedback crosstalk between the excitatory neurotransmitter gluta
Externí odkaz:
https://doaj.org/article/960e7357f21c40f4979af4b90801540e
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-10 (2022)
Abstract Neonatal hypoxic-ischemic encephalopathy (HIE) induced by perinatal asphyxia is a major cause of neurological disability among infants. Dihydroartemisinin (DHA), derived from artemisinin, well known as an anti-malarial medicine, was proved t
Externí odkaz:
https://doaj.org/article/925433ea0a24404f92fe0eab0c4f8ce8