Zobrazeno 1 - 10
of 436
pro vyhledávání: '"Zhi-nan Chen"'
Autor:
Ke Wang, Xiaohong Chen, Peng Lin, Jiao Wu, Qiang Huang, Zhi‐Nan Chen, Jiale Tian, Hao Wang, Ye Tian, Mingyan Shi, Meirui Qian, Bengang Hui, Yumeng Zhu, Ling Li, Rui Yao, Huijie Bian, Ping Zhu, Ruo Chen, Liang Chen
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract Immunosuppression is a major hallmark of tumor progression in non‐small cell lung cancer (NSCLC). Cluster of differentiation 147 (CD147), an important pro‐tumorigenic factor, is closely linked to NSCLC immunosuppression. However, the rol
Externí odkaz:
https://doaj.org/article/9d060af812d046ce8d1c05efa275ac99
Publikováno v:
MedComm, Vol 5, Iss 7, Pp n/a-n/a (2024)
Abstract Skeletal muscle is an important motor organ with multinucleated myofibers as its smallest cellular units. Myofibers are formed after undergoing cell differentiation, cell–cell fusion, myonuclei migration, and myofibril crosslinking among o
Externí odkaz:
https://doaj.org/article/76436af2f5684129aa7b140c6b7b4012
Autor:
Jia-Jia Zhang, Chang-Geng Song, Miao Wang, Gai-Qin Zhang, Bin Wang, Xi Chen, Peng Lin, Yu-Meng Zhu, Zhi-Chuan Sun, Ya-Zhou Wang, Jian-Li Jiang, Ling Li, Xiang-Min Yang, Zhi-Nan Chen
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 10, Pp 1135-1152 (2023)
Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. Although the inefficiency of morphine in inducing the endocytosis of MOR underlies the development of morphine toleran
Externí odkaz:
https://doaj.org/article/d68f464005ed4810b8ecc5b85b29dfcd
Autor:
Lin He, Hao Li, Can Li, Ze‐Kun Liu, Meng Lu, Ren‐Yu Zhang, Dong Wu, Ding Wei, Jie Shao, Man Liu, Hao‐Lin Wei, Cong Zhang, Zhe Wang, Ling‐Min Kong, Zhi‐Nan Chen, Huijie Bian
Publikováno v:
Cancer Communications, Vol 43, Iss 9, Pp 981-1002 (2023)
Abstract Background The mechanism of hepatitis B virus (HBV)‐induced carcinogenesis remains an area of interest. The accumulation of hepatitis B surface antigen in the endoplasmic reticulum (ER) of hepatocytes stimulates persistent ER stress. Activ
Externí odkaz:
https://doaj.org/article/1897dcbb12144a1ba7353c0c89c8b9a8
Autor:
Fang‐Zheng Qi, Hui‐Shan Su, Bo Wang, Luo‐Meng Qian, Yang Wang, Chen‐Hui Wang, Ya‐Xin Hou, Ping Chen, Qing Zhang, Dong‐Mei Li, Hao Tang, Jian‐Li Jiang, Hui‐Jie Bian, Zhi‐Nan Chen, Si‐He Zhang
Publikováno v:
MedComm, Vol 5, Iss 3, Pp n/a-n/a (2024)
Abstract Therapeutic antibodies (Abs) improve the clinical outcome of cancer patients. However, on‐target off‐tumor toxicity limits Ab‐based therapeutics. Cluster of differentiation 147 (CD147) is a tumor‐associated membrane antigen overexpre
Externí odkaz:
https://doaj.org/article/ebc7e3f5a09f438d88815a172b1fdfa3
Autor:
Ping Zhu, Shi-You Li, Jin Ding, Zhou Fei, Sheng-Nan Sun, Zhao-Hui Zheng, Ding Wei, Jun Jiang, Jin-Lin Miao, San-Zhong Li, Xing Luo, Kui Zhang, Bin Wang, Kun Zhang, Su Pu, Qian-Ting Wang, Xin-Yue Zhang, Gao-Liu Wen, Jun O. Liu, John Thomas August, Huijie Bian, Zhi-Nan Chen, You-Wen He
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 6, Pp 616-624 (2023)
Glioblastoma (GBM) is a lethal cancer with limited therapeutic options. Dendritic cell (DC)-based cancer vaccines provide a promising approach for GBM treatment. Clinical studies suggest that other immunotherapeutic agents may be combined with DC vac
Externí odkaz:
https://doaj.org/article/38ec1a088c2841dabe8481860dfceee9
Autor:
Huijie Bian, Liang Chen, Zhao-Hui Zheng, Xiu-Xuan Sun, Jie-Jie Geng, Ruo Chen, Ke Wang, Xu Yang, Shi-Rui Chen, Si-Yu Chen, Rong-Hua Xie, Kui Zhang, Jin-Lin Miao, Jun-Feng Jia, Hao Tang, Shuang-Shuang Liu, Hong-Wei Shi, Yong Yang, Xiao-Chun Chen, Vinay Malhotra, Nosheen Nasir, Iffat Khanum, Faisal Mahmood, Saeed Hamid, Claudio Marcel Berdun Stadnik, Kengi Itinose, Caroline Cândida Carvalho de Oliveira, Cesar Dusilek, Lucas Rivabem, Adilson Joaquim Westheimer Cavalcante, Suzara Souto Lopes, Wladmir Faustino Saporito, Fábio José Concilio Fucci, Jesus Abraham Simon-Campos, Ling Wang, Lin-Na Liu, Qing-Yi Wang, Ding Wei, Zheng Zhang, Zhi-Nan Chen, Ping Zhu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Meplazumab, a humanized CD147 antibody, has shown favourable safety and efficacy in our previous clinical studies. In DEFLECT (NCT04586153), 167 patients with severe COVID-19 were enroled and randomized to receive three dosages of meplazumab
Externí odkaz:
https://doaj.org/article/4930312c464b4f5aab592cc1118df724
Autor:
Jiejie Geng, Xu Yang, Kun Wang, Ke Wang, Ruo Chen, Zhi-Nan Chen, Chuan Qin, Guizhen Wu, Youchun Wang, Ke Xu, Peng Du, Jiangning Liu, Shirui Chen, Tao Zhang, Xiuxuan Sun, Ting Guo, Ying Shi, Zheng Zhang, Ding Wei, Peng Lin, Qingyi Wang, Jing Yuan, Jiuxin Qu, Jin Zou, Yingxia Liu, Hongzhou Lu, Ping Zhu, Huijie Bian, Liang Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract The Omicron variants of SARS-CoV-2, primarily authenticated in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here, we systemically examined immunological and metabolic characteristics of Omicron variants infe
Externí odkaz:
https://doaj.org/article/502933fdde7444868e45a88e3af47999
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1135-1144 (2022)
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants is threatening public health around the world. Endocytosis functions as an important way for viral infection, and SARS-CoV-2 bears no exception. However, the
Externí odkaz:
https://doaj.org/article/87dade94fdb145869c4fedb680946111
Autor:
Jiao Wu, Liang Chen, Chuan Qin, Fei Huo, Xue Liang, Xu Yang, Kui Zhang, Peng Lin, Jiangning Liu, Zhuan Feng, Jiansheng Zhou, Zhuo Pei, Yatao Wang, Xiu-Xuan Sun, Ke Wang, Jiejie Geng, Zhaohui Zheng, Xianghui Fu, Man Liu, Qingyi Wang, Zheng Zhang, Huijie Bian, Ping Zhu, Zhi-Nan Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract COVID‐19 patients can develop clinical and histopathological features associated with fibrosis, but the pathogenesis of fibrosis remains poorly understood. CD147 has been identified as a universal receptor for SARS-CoV-2 and its variants,
Externí odkaz:
https://doaj.org/article/f3e46ee400804832b5eb1b08549fe995