Výsledky vyhledávání - "Zhi-chun Ding"

Akademický článek

Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy

Autor: Gang Zhou, David H Munn, Zhi-Chun Ding, Marco L Davila, Hongyan Xu, Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Gregory Gorman, Roni Bollag, Locke J Bryan, Gary A Piazza

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)

Background Adoptive cell therapy (ACT) using genetically modified T cells has evolved into a promising treatment option for patients with cancer. However, even for the best-studied and clinically validated CD19-targeted chimeric antigen receptor (CAR

Externí odkaz: https://doaj.org/article/a814f619a9934bacafbe74860b95a4f2

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Akademický článek

The Monocytes That Repopulate in Mice After Cyclophosphamide Treatment Acquire a Neutrophil Precursor Gene Signature and Immunosuppressive Activity

Autor: Zhi-Chun Ding, Nada S. Aboelella, Locke Bryan, Huidong Shi, Gang Zhou

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Cyclophosphamide (CTX) is a major component of the chemotherapy conditioning regimens used in the clinic to prepare cancer patients for hematopoietic stem cell transplantation or adoptive T cell therapy. Previous studies have shown that CTX given at

Externí odkaz: https://doaj.org/article/3421a30b17504bd98866e5f8b47e1590

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Akademický článek

Cytotoxic Chemotherapy and CD4+ Effector T Cells: An Emerging Alliance for Durable Antitumor Effects

Autor: Zhi-Chun Ding, Gang Zhou

Publikováno v: Clinical and Developmental Immunology, Vol 2012 (2012)

Standard cytotoxic chemotherapy can initially achieve high response rates, but relapses often occur in patients and represent a severe clinical problem. As increasing numbers of chemotherapeutic agents are found to have immunostimulatory effects, the

Externí odkaz: https://doaj.org/article/7ddfab3fe3d64e9f85a81e6223e78fbe

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Supplementary Data from Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway

Autor: Han-Fei Ding, Yunhong Zha, Zheng Dong, Chunhong Yan, Oliver Fiehn, Bei Gao, Jeong-Hyeon Choi, Eun Jeong Park, Zhi-Chun Ding, Puttur D. Prasad, Muthusamy Thangaraju, Ahmet Alptekin, Yajie Yu, Jane Ding, Bingwei Ye, Yingfeng Xia

Supplementary Figures: SF1, MYCN amplification vs SGOC gene expression; SF2, MYCN activates SGOC gene expression; SF3, ATF4 activates SGOC gene expression; SF4, MYCN and ATF4 form a positive feedback loop; SF5, MYCN sensitizes neuroblastoma cells to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4eed00d7c89db6dda33a973da94ab0
https://doi.org/10.1158/0008-5472.22422483

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Data from Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway

MYCN amplification drives the development of neuronal cancers in children and adults. Given the challenge in therapeutically targeting MYCN directly, we searched for MYCN-activated metabolic pathways as potential drug targets. Here we report that neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8122c6704fb536426d3c3ca32e8ae49f
https://doi.org/10.1158/0008-5472.c.6511236.v1

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Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy

Autor: Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Zhi-Chun Ding, Hongyan Xu, Gregory Gorman, Roni Bollag, Marco L Davila, Locke J Bryan, David H Munn, Gary A Piazza, Gang Zhou

Publikováno v: Journal for immunotherapy of cancer. 10(7)

BackgroundAdoptive cell therapy (ACT) using genetically modified T cells has evolved into a promising treatment option for patients with cancer. However, even for the best-studied and clinically validated CD19-targeted chimeric antigen receptor (CAR)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e599ec3d9ead270f2101a6ca9d8fbb
https://pubmed.ncbi.nlm.nih.gov/35882449

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