Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Zhi-Zheng Wang"'
Autor:
Zhi-Zheng Wang, Min-Jie Cao, Junjie Yan, Jin Dong, Mo-Xian Chen, Jing-Fang Yang, Jian-Hong Li, Rui-Ning Ying, Yang-Yang Gao, Li Li, Ya-Nan Leng, Yuan Tian, Kamalani Achala H. Hewage, Rong-Jie Pei, Zhi-You Huang, Ping Yin, Jian-Kang Zhu, Ge-Fei Hao, Guang-Fu Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Abscisic acid (ABA) is the primary preventing factor of seed germination, which is crucial to plant survival and propagation. ABA-induced seed germination inhibition is mainly mediated by the dimeric PYR/PYL/RCAR (PYLs) family members. Howev
Externí odkaz:
https://doaj.org/article/d1de552eff3843fab64b84cefd7eb071
Autor:
Zhi-Zheng Wang, Jun Weng, Jing Qi, Xin-Xin Fu, Ban-Bin Xing, Yang Hu, Chun-Hsiang Huang, Chin-Yu Chen, Zigong Wei
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
The zoonosis caused by Nocardia is increasing seriously. But commonly used antibiotic drugs often lead to resistance. N. seriolae dUTPase (NsdUTPase) plays a key role in the proliferation of Nocardia, and was regarded as a potent drug target. However
Externí odkaz:
https://doaj.org/article/ac18eb85d6d44145bd23eadfbdec9365
Publikováno v:
Trends in Biochemical Sciences. 48:539-552
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea589177859b26abce26ddceec558049
https://doi.org/10.1016/j.tibs.2023.01.008
https://doi.org/10.1016/j.tibs.2023.01.008
Publikováno v:
Journal of Agricultural and Food Chemistry. 71:52-64
Using agrochemicals against pest insects, fungi, and weeds plays a major part in maintaining and improving crop yields, which helps to solve the issue of food security. Due to the limited targets and resistance of agrochemicals, protein kinases are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ccb7d7f9722e37c4a09c45a854caa
https://doi.org/10.1021/acs.jafc.2c06222
https://doi.org/10.1021/acs.jafc.2c06222
Autor:
Xing-Xing Shi, Zhi-Zheng Wang, Xin-Lin Sun, Yu-Liang Wang, Huan-Xiang Liu, Fan Wang, Ge-Fei Hao, Guang-Fu Yang
Publikováno v:
Green Chemistry. 25:2170-2219
This review aims to introduce the rich applications of chemical toxicological data for environmental risk assessment and green chemical design by illustrating referable examples or cases. Further, we present a comprehensive toxicology databank.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b961232c09c090bc4eaac0f18ee139dd
https://doi.org/10.1039/d2gc03973g
https://doi.org/10.1039/d2gc03973g
Autor:
Ming-Shu Wang, Zhi-Zheng Wang, Zi-Long Li, Yi Gong, Cheng-Xiang Duan, Qian-Hui Cheng, Wei Huang, Guang-Fu Yang
Publikováno v:
Journal of Medicinal Chemistry. 66:611-626
Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of T-cell activation, and targeting HPK1 is considered a promising strategy for improving responses to antitumor immune therapies. The biggest challenge of HPK1 inhibitor design is to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686c5b7138c4a98cc9f48a7271ea1d27
https://doi.org/10.1021/acs.jmedchem.2c01551
https://doi.org/10.1021/acs.jmedchem.2c01551
Autor:
Xing-Xing Shi, Fan Wang, Zhi-Zheng Wang, Guang-Yi Huang, Min Li, Jesus Simal-Gandara, Ge-Fei Hao, Guang-Fu Yang
Publikováno v:
Critical Reviews in Food Science and Nutrition. :1-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf238b1498f99d4d60838d5ddd9f989
https://doi.org/10.1080/10408398.2022.2152423
https://doi.org/10.1080/10408398.2022.2152423
Publikováno v:
Drug Discovery Today. 27:2216-2225
Kinases have a crucial role in cell signaling and are important drug targets, given that aberrant kinase activity has been linked to most disease areas. Therefore, kinase inhibitors (KIs) have significant potential as new therapeutics. In recent year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f001839f3e5c0f60381e310f7168d1d
https://doi.org/10.1016/j.drudis.2022.04.002
https://doi.org/10.1016/j.drudis.2022.04.002
ACFIS 2.0: an improved web-server for fragment-based drug discovery via a dynamic screening strategy
Publikováno v:
Nucleic Acids Research.
Drug discovery, which plays a vital role in maintaining human health, is a persistent challenge. Fragment-based drug discovery (FBDD) is one of the strategies for the discovery of novel candidate compounds. Computational tools in FBDD could help to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04c1d32471a2603ad467e267c4b5f995
https://doi.org/10.1093/nar/gkad348
https://doi.org/10.1093/nar/gkad348
Autor:
Zhi-Zheng Wang, Chao Yi, Jun-Jie Huang, Teng-Fei Xu, Kang-Zhi Chen, Zu-Sheng Wang, Ya-Ping Xue, Jie-Lian Lu, Biao Nie, Ying-Jun Zhang, Chuan-Fei Jin, Ge-Fei Hao
Publikováno v:
Journal of medicinal chemistry.
Inadequate bioavailability is one of the most critical reasons for the failure of oral drug development. However, the way that substructures affect bioavailability remains largely unknown. Serotonin transporter (SERT) inhibitors are first-line drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1402a956b5d6ba2a9755c10692a23fce
https://pubmed.ncbi.nlm.nih.gov/36598095
https://pubmed.ncbi.nlm.nih.gov/36598095