Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Zhi-Yun Meng"'
Autor:
Yu-lu Liu, Xiao-xia Zhu, Li-yun Niu, Ya Gao, Hui GAN, Zhuo-na Wu, Jian LI, Su-xiang Feng, Gui-fang Dou, Ruo-lan Gu, Zhi-yun Meng
Publikováno v:
Journal of pharmaceutical sciences.
GEN-0828, a proposed clinical candidate for hemophilia and trauma hemorrhage treatment, is a novel recombinant activated human factor VII (rFVIIa). The purpose of this paper is to compare the pharmacokinetics and pharmacodynamics of GEN-0828 in hemop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b16946312b3a9f31629df09a78eb840
https://pubmed.ncbi.nlm.nih.gov/36565924
https://pubmed.ncbi.nlm.nih.gov/36565924
Publikováno v:
Chinese Journal of Cancer Research
Objective This phase I study was to evaluate safety, maximum tolerated dose, pharmacokinetics and preliminary antitumor activity of chidamide, a novel subtype-selective histone deacetylase (HDAC) inhibitor, in combination with paclitaxel and carbopla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dace52771bbbe32e2e01c7d27ac8c7e
https://doi.org/10.21147/j.issn.1000-9604.2016.04.08
https://doi.org/10.21147/j.issn.1000-9604.2016.04.08
Autor:
Mei Dong, Lu Xianping, Ning Zhiqiang, Haixiang Cao, Jia-Lian Xu, Feng-Yi Feng, Puyuan Xing, Gui-Fang Dou, Zhi-Yun Meng, Yuankai Shi
Publikováno v:
Cancer Chemotherapy and Pharmacology. 69:1413-1422
Chidamide (CS055/HBI-8000) is a new benzamide class of histone deacetylase inhibitor with marked anti-tumor activity. This study reports the phase I results. Patients with advanced solid tumors or lymphomas received oral doses of 5, 10, 17.5, 25, 32.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6acb705ac2fb1b5a1aadf818827653d
https://doi.org/10.1007/s00280-012-1847-5
https://doi.org/10.1007/s00280-012-1847-5
Publikováno v:
Journal of Chromatography B. 852:617-624
A novel HPLC-UV method with pre-column derivatization by using 2-mercaptoethanol was established for determination of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE) in dog plasma. The derivatives were identified by mass spectrometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f41466432521ee190ec25d7846243f
https://doi.org/10.1016/j.jchromb.2007.02.040
https://doi.org/10.1016/j.jchromb.2007.02.040
Publikováno v:
Journal of Chromatography B. 850:92-100
The pharmacokinetics (PK) and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine (3,4-DCPB), a novel antiepileptic drug, were investigated after its oral administration to rats (100 mg/kg) by HPLC. The absorption and elimination of 3,4-DCPB w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5adee903044f460ed5d70daac02d11
https://doi.org/10.1016/j.jchromb.2006.11.010
https://doi.org/10.1016/j.jchromb.2006.11.010
Autor:
Ying-Yuan Lu, Guo-Liang Zhang, Gui-Fang Dou, Pu Li, Zhi-Yun Meng, Zhong-Jun Li, Xin Wang, Jian Li, Shu-Chun Li, Hong Ren, Chuang Lu, Ya-Qing Lou
Publikováno v:
Scientific Reports
Fructose-based 3-acetyl-2,3-dihydro-1,3,4-oxadiazole (GLB) is a novel antitumor agent and belongs to glycosylated spiro-heterocyclic oxadiazole scaffold derivative. This research first reported a simple, specific, sensitive and stable high performanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e30132d74ad7a0ea794e93278d65dd
https://doi.org/10.1038/srep11906
https://doi.org/10.1038/srep11906
Autor:
Hui, Gan, Zhi-Yun, Meng, Zhuo-Na, Wu, Xiao-Xia, Zhu, Ruo-Lan, Gu, Wen-Zhong, Sun, Gui-Fang, Dou
Publikováno v:
Zhongguo shi yan xue ye xue za zhi. 23(3)
As a widespread phenomenon in living system, molecular self-assembly has become the meeting point of multidisciplinary research including chemistry, biology, materials science and medicine. In recent years, the rapid development in molecular self-ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1016df12747934e1afd0b4e0204715ec
https://pubmed.ncbi.nlm.nih.gov/26117059
https://pubmed.ncbi.nlm.nih.gov/26117059
Autor:
Jun-Ting, Dai, Zhi-Yun, Meng, Xiao-Xia, Zhu, Hui, Gan, Ruo-Lan, Gu, Bo, Yang, Li-Ying, Yu, Gui-Fang, Dou
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 49(7)
A rapid, sensitive and simple liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed for the simultaneous determination of yogliptin and its metabolite in Wistar rat plasma. Linagliptin and dexamethasone were chosen as the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9af9f960994fef22764d482796f38b8e
https://pubmed.ncbi.nlm.nih.gov/25233638
https://pubmed.ncbi.nlm.nih.gov/25233638
Autor:
Zi-Hua, Zheng, Xiao-Xia, Zhu, Hui, Gan, Ruo-Lan, Gu, Zhuo-Na, Wu, Zhi-Yun, Meng, Gui-Fang, Dou
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 48(8)
Healthy Beagle dogs were administrated with batroxobin by intravenous infusion at high, medium and low doses. The study of pharmacodynamics and pharmacokinetics was intended to clarify the relevance of them and provided strong evidence for clinical u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cdda0f889276081f6f6005f319973bf
https://pubmed.ncbi.nlm.nih.gov/24187841
https://pubmed.ncbi.nlm.nih.gov/24187841
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 48(3)
This paper is to report the study of the metabolism of forscolin in plasma and liver microsomes for guiding clinical therapy. Forscolin was quantified by HPLC-MS/MS. The metabolic stability of forscolin in rat, Beagle dog, monkey and human plasma and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efabc2c69f11490747f7037ba6909805
https://pubmed.ncbi.nlm.nih.gov/23724652
https://pubmed.ncbi.nlm.nih.gov/23724652