Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Zhi-Ting Cao"'
Autor:
Qian-Ni Ye, Long Zhu, Jie Liang, Dong-Kun Zhao, Tai-Yu Tian, Ya-Nan Fan, Si-Yi Ye, Hua Liu, Xiao-Yi Huang, Zhi-Ting Cao, Song Shen, Jun Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The functions of natural killer (NK) and T cells in innate and adaptive immunity, as well as their functions in tumor eradication, are complementary and intertwined. Here we show that utilization of multi-specific antibodies or nano-antibodi
Externí odkaz:
https://doaj.org/article/d0d29d1d2a0d4cf7acfb14c8eed0e4c5
Autor:
Qi Zhou, Jun Wang, Na Shu, Jia-Xian Li, Yang Chen, Zhi-Bin Zhao, Sui-Juan Zheng, Jin-Zhi Du, Min Ma, Zhi-Ting Cao
Publikováno v:
Biomaterials Science. 9:2508-2518
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Sorafenib (sfb) is widely used in clinics for advanced HCC therapy. However, the therapeutic efficacy of sfb is suboptimal due to its poor water solubility, low bioa
Publikováno v:
Journal of Controlled Release. 324:47-54
Polymeric micelles hold great potential for anticancer drug delivery. Sufficient integrity of polymeric micelles after intravenous injection is critical for successful drug delivery to solid tumors, but accurate measurement of the in vivo micellar in
Publikováno v:
Nano Letters. 19:2688-2693
The inherent features of small interfering RNA (siRNA), including a relatively high molecular weight, negative charge, and hydrophilic nature, lead to the widespread use of cationic polymers and lipid-based nanocarriers, which might induce potential
Publikováno v:
Biomaterials Science. 7:4698-4707
Rheumatoid arthritis (RA) is a systemic autoimmune disease that can cause irreversible joint deformity. There is still no cure for RA, and current therapeutics, including methotrexate and adalimumab, cause serious off-target effects and systemic immu
Autor:
Wei Jiang, Zhi-Ting Cao, Xianzhu Yang, Yue Zhang, Jun Wang, Ji-Long Wang, Meng-Hua Xiong, Yucai Wang, Hou-Bing Zhang, Li-Qin Gan
Publikováno v:
ACS nano. 14(3)
Polymeric nanoparticles (NPs) are an important category of drug delivery systems, and their in vivo fate is closely associated with delivery efficacy. Analysis of the protein corona on the surface ...
Autor:
Cong-Fei Xu, Zhi-Yao Chen, Ying-Li Luo, Yang Liu, Zhen Gu, Jing Liu, Zhi-Ting Cao, Zi-Dong Lu, Kai-Ge Chen, Jun Wang, Hongjun Li, Xianzhu Yang, Song Shen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
The NLRP3 inflammasome is a well-studied target for the treatment of multiple inflammatory diseases, but how to promote the current therapeutics remains a large challenge. CRISPR/Cas9, as a gene editing tool, allows for direct ablation of NLRP3 at th
Publikováno v:
Nano Research. 11:4183-4198
Convincing evidence indicates that the existence of cancer stem cells (CSCs) within malignant tumors is mostly responsible for the failure of chemotherapy. Therefore, instead of merely targeting bulk cancer cells, simultaneous elimination of both CSC
Autor:
Jun Wang, Cong-Fei Xu, Ying-Li Luo, Xiao-Jiao Du, Zhen Gu, Xianzhu Yang, Ji-Long Wang, Hongjun Li, Jing Liu, Zhi-Ting Cao
Publikováno v:
ACS Nano. 12:994-1005
The CRISPR/Cas9 gene editing technology holds promise for the treatment of multiple diseases. However, the inability to perform specific gene editing in targeted tissues and cells, which may cause off-target effects, is one of the critical bottleneck
Autor:
Yucai Wang, Zhi-Ting Cao, Xiao-Jiao Du, Hongjun Li, Jin-Zhi Du, Jun Wang, Shoaib Iqbal, Ji-Long Wang
Publikováno v:
Biomaterials Science. 6:642-650
Surface charge plays an important role in determining the interactions of nanoparticles with biological components. Substantial studies have demonstrated that surface charge affects the fate of nanoparticles after intravenous administration; however,