Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zhi-Shun Huang"'
Autor:
Weir-Torn Jiaang, Huey-Nan Wu, Szu-Huei Wu, Zhi-Shun Huang, Chi-Chen Yang, Jyh-Haur Chern, Shiow-Ju Lee, Andrew Yueh, Chungming Chang, Han-Shu Hu, Ren-Huang Wu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:110-119
Dengue virus (DENV) causes disease globally, resulting in an estimated 25 to 100 million new infections per year. No effective DENV vaccine is available, and the current treatment is only supportive. Thus, there is an urgent need to develop therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08d470bc52fb4943dc22bb953312d1b
https://doi.org/10.1128/aac.01281-13
https://doi.org/10.1128/aac.01281-13
Publikováno v:
FEBS Letters. 578:345-350
We used synthetic DNA oligos to investigate the nucleic acid chaperone properties of the N terminal domain of hepatitis delta antigen (NdAg). We found that NdAg possessed a bona fide chaperone activity. NdAg could distinguish subtle differences in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059fc27e8e90dcb483b1dfd4888162cf
https://doi.org/10.1016/j.febslet.2004.11.043
https://doi.org/10.1016/j.febslet.2004.11.043
Autor:
Ching Wen Lin, Bo Shun Chen, Tsung Cheng Chang, Hsiu Ling Tsui, Chun Chung Wang, Zhi Shun Huang, Page B C Chu, Huey-Nan Wu
Publikováno v:
Nucleic Acids Research. 31:6481-6492
The N terminal region of hepatitis delta antigen (HDAg), referred to here as NdAg, has a nucleic acid chaperone activity that modulates the ribozyme activity of hepatitis delta virus (HDV) RNA and stimulates hammerhead ribozyme catalysis. We characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5012a98665388503206b39ccfd4d565f
https://doi.org/10.1093/nar/gkg857
https://doi.org/10.1093/nar/gkg857
Publikováno v:
Journal of virology. 88(14)
The virion of dengue virus (DENV) is composed of a viral envelope covering a nucleocapsid formed by a complex of viral genomic RNA and core protein (CP). DENV CP forms a dimer via the internal α2 and α4 helices of each monomer. Pairing of α2-α2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cd614a74cf91b86097a0603cefe712
https://pubmed.ncbi.nlm.nih.gov/24807709
https://pubmed.ncbi.nlm.nih.gov/24807709
Autor:
Zhi-Shun Huang, Huey-Nan Wu
Publikováno v:
Journal of Biological Chemistry. 273:26455-26461
In this study, we identified an activity of the hepatitis delta antigen that both modulates the cis-cleaving activities of hepatitis delta virus (HDV) genomic RNA fragments and facilitates the trans-cleavage reactions between hammerhead ribozymes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd4cddbbca0c38cbc9a6917208d7efd
https://doi.org/10.1074/jbc.273.41.26455
https://doi.org/10.1074/jbc.273.41.26455
Publikováno v:
FEBS Letters. 413:299-303
A mutational analysis of the helix 3 (H3) region of hepatitis delta virus (HDV) ribozymes disclosed that an AU at the first base pair of H3 elevates the catalytic activity of various cis- and trans-acting HDV ribozymes. A GC to AU substitution at thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c1bb2b6ae1ea112f2d4cdf09af2c51
https://doi.org/10.1016/s0014-5793(97)00902-2
https://doi.org/10.1016/s0014-5793(97)00902-2
Publikováno v:
Biochemistry. 35:12303-12312
The sequence, secondary structure, and size requirements of the helix 2 region (H2) of a cis-acting hepatitis delta virus ribozyme Rz 1 were examined in this study. Mutational analysis was performed, and the cleavage rate of each H2 mutant of Rz 1 wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11142b01f2ad97268cf6c9a8ff04d361
https://doi.org/10.1021/bi961219m
https://doi.org/10.1021/bi961219m
Autor:
Huey-Nan Wu, Zhi-Shun Huang
Publikováno v:
Nucleic Acids Research. 20:5937-5941
To determine the sequence requirements and structural features of the self-cleavage domain of hepatitis delta virus (HDV) antigenomic RNA, we constructed a series of mutants and measured the rate constant of the cleavage reaction for each. The self-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69133c99f9f22ba71e3040e477bd8df4
https://doi.org/10.1093/nar/20.22.5937
https://doi.org/10.1093/nar/20.22.5937
Publikováno v:
The Journal of biological chemistry. 278(8)
We have previously shown that the N-terminal domain of hepatitis delta virus (NdAg) has an RNA chaperone activity in vitro (Huang, Z. S., and Wu, H. N. (1998) J. Biol. Chem. 273, 26455-26461). Here we investigate further the basis of the stimulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e0ceaeddd74627446ae590adaf3703
https://pubmed.ncbi.nlm.nih.gov/12466279
https://pubmed.ncbi.nlm.nih.gov/12466279
Autor:
Pak-Guan Teoh1,2, Zhi-Shun Huang2, Wen-Li Pong2, Po-Chiang Chen2, Huey-Nan Wu2 hnwu@gate.sinica.edu.tw
Publikováno v:
Journal of Virology. Jul2014, Vol. 88 Issue 14, p7998-8015. 18p.