Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Zhi-Qin Jiang"'
Autor:
Isidore Rigoutsos, Sang Kil Lee, Su Youn Nam, Simone Anfossi, Barbara Pasculli, Martin Pichler, Yi Jing, Cristian Rodriguez-Aguayo, Aristeidis G. Telonis, Simona Rossi, Cristina Ivan, Tina Catela Ivkovic, Linda Fabris, Peter M. Clark, Hui Ling, Masayoshi Shimizu, Roxana S. Redis, Maitri Y. Shah, Xinna Zhang, Yoshinaga Okugawa, Eun Jung Jung, Aristotelis Tsirigos, Li Huang, Jana Ferdin, Roberta Gafà, Riccardo Spizzo, Milena S. Nicoloso, Anurag N. Paranjape, Maryam Shariati, Aida Tiron, Jen Jen Yeh, Raul Teruel-Montoya, Lianchun Xiao, Sonia A. Melo, David Menter, Zhi-Qin Jiang, Elsa R. Flores, Massimo Negrini, Ajay Goel, Menashe Bar-Eli, Sendurai A. Mani, Chang Gong Liu, Gabriel Lopez-Berestein, Ioana Berindan-Neagoe, Manel Esteller, Scott Kopetz, Giovanni Lanza, George A. Calin
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-21 (2017)
Abstract Background Non-coding RNAs have been drawing increasing attention in recent years as functional data suggest that they play important roles in key cellular processes. N-BLR is a primate-specific long non-coding RNA that modulates the epithel
Externí odkaz:
https://doaj.org/article/1e8d188da0bf4c3faa5d2b002a7f8760
Autor:
Scott Kopetz, Garth Powis, Michael J. Overman, Jeffrey Morris, Bradley M. Broom, Mingshan Cheng, Susan Airhart, Feng Tian, Christopher Bristow, Bahar Salimian Rizi, Alexey V. Sorokin, Ji Wu, Shanequa Manuel, Maria P. Morelli, Andreas Varkaris, David G. Menter, Zhi-Qin Jiang, Kanwal Raghav, Anastasia Katsiampoura
Association between surgical specimen size and rate of PDX establishment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1a3561b3894370a65e992a0deea967
https://doi.org/10.1158/1535-7163.22503978.v1
https://doi.org/10.1158/1535-7163.22503978.v1
Autor:
Scott Kopetz, Garth Powis, Michael J. Overman, Jeffrey Morris, Bradley M. Broom, Mingshan Cheng, Susan Airhart, Feng Tian, Christopher Bristow, Bahar Salimian Rizi, Alexey V. Sorokin, Ji Wu, Shanequa Manuel, Maria P. Morelli, Andreas Varkaris, David G. Menter, Zhi-Qin Jiang, Kanwal Raghav, Anastasia Katsiampoura
Developing realistic preclinical models using clinical samples that mirror complex tumor biology and behavior are vital to advancing cancer research. While cell line cultures have been helpful in generating preclinical data, the genetic divergence be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbba52453d564e5c7b8979fa5a18c1e
https://doi.org/10.1158/1535-7163.c.6537579.v1
https://doi.org/10.1158/1535-7163.c.6537579.v1
Autor:
Scott Kopetz, Gary E. Gallick, Alain R. Thierry, Michael J. Overman, Cathy Eng, Robert A. Wolff, David G. Menter, Anastasia D. Katsiampoura, David R. Fogelman, Arvind Dasari, Kanwal Raghav, Marc Ychou, Brice Pastor, Feng Tian, Laura Henderson, Zhi-Qin Jiang, Ji Yuan Wu, Nila U. Parikh, Christine M. Parseghian
Purpose: Aberrant activation of the intracellular tyrosine kinase Src has been implicated as a mechanism of acquired chemotherapy resistance in metastatic colorectal cancer (mCRC). Here, the oral tyrosine kinase Src inhibitor, dasatinib, was investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493cba9094cd2e6c43821d133756c6a5
https://doi.org/10.1158/1078-0432.c.6526826
https://doi.org/10.1158/1078-0432.c.6526826
Autor:
Scott Kopetz, Marc Ychou, Safia El Messaoudi, Cynthia Sanchez, Michael J. Overman, Jonathan M. Loree, Christine Parseghian, Anastasia D. Katsiampoura, Zhi-Qin Jiang, Brice Pastor, Alain R. Thierry
Purpose: Liquid biopsies allow the tracking of clonal dynamics and detection of mutations during treatment.Experimental Design: We evaluated under blinded conditions the ability of cell-free DNA (cfDNA) to detect RAS/BRAF mutations in the plasma of 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bc00964f6d5b3c18327e32f627eabf
https://doi.org/10.1158/1078-0432.c.6525203.v1
https://doi.org/10.1158/1078-0432.c.6525203.v1
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 39K, HT29 PLX4720 resistant clone was treated with EGFR siRNA for 48 h, and then treated with 1�M PLX4720 for further two weeks. EGFR knockdown reduced sensitivity to PLX4720 by numbers of formed colonies (# P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc22a97db08c50678f13fa79f95abaf
https://doi.org/10.1158/1078-0432.22445823.v1
https://doi.org/10.1158/1078-0432.22445823.v1
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 30K, BRAF mutant cell lines utilized in the RPPA analysis. Cells were lysed at approximately 70% confluence in 10% serum. Of note, Colo201 and Colo205 are derived from the same colon cancer patient, as are HT29 and WiDr. Cell lines were ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683ae81e3b5084501e2b3a8720ad7512
https://doi.org/10.1158/1078-0432.22445820
https://doi.org/10.1158/1078-0432.22445820
Autor:
Scott Kopetz, Gary E. Gallick, Alain R. Thierry, Michael J. Overman, Cathy Eng, Robert A. Wolff, David G. Menter, Anastasia D. Katsiampoura, David R. Fogelman, Arvind Dasari, Kanwal Raghav, Marc Ychou, Brice Pastor, Feng Tian, Laura Henderson, Zhi-Qin Jiang, Ji Yuan Wu, Nila U. Parikh, Christine M. Parseghian
Validation of peripheral blood mononuclear cells as a biomarker of Src inhibition. Freshly collected peripheral blood mononuclear cells from a healthy volunteer were treated ex-vivo with dasatinib 300 nM or hydrogen peroxide 0.05 mM. The peripheral b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42048aa738ec1b6e17d9bcc70397504b
https://doi.org/10.1158/1078-0432.22468073
https://doi.org/10.1158/1078-0432.22468073
Autor:
Scott Kopetz, Michael A. Davies, Gary E. Gallick, Jayesh Desai, Garth Powis, Gordon B. Mills, Gideon Bollag, William G. Bornman, Xi M. Tang, Ignacio I. Wistuba, Zhi-Qin Jiang, Y.N. Vashisht Gopal, Farshid Dayyani, Robert Lemos, Chun C. Tsao, John M. Mariadason, Feng Tian, Muling Mao
PDF file - 338K, Cells were incubated for 24h (HT29, Colon205) or 48 h (RKO) with PLX4720 (1 M for all cell lines), LY294002 (15 M for all cell lines) or their combination. Cells were then harvested and stained with propidium iodide. DNA concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e654ec4ff37df80a7793f4485bc57d9
https://doi.org/10.1158/1078-0432.22445841
https://doi.org/10.1158/1078-0432.22445841
Autor:
Scott Kopetz, Gary E. Gallick, Alain R. Thierry, Michael J. Overman, Cathy Eng, Robert A. Wolff, David G. Menter, Anastasia D. Katsiampoura, David R. Fogelman, Arvind Dasari, Kanwal Raghav, Marc Ychou, Brice Pastor, Feng Tian, Laura Henderson, Zhi-Qin Jiang, Ji Yuan Wu, Nila U. Parikh, Christine M. Parseghian
Operating characteristics. A summary of the probability of stopping the trial early for the indicated true response rates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1507020a7c8559fc408126becd09af
https://doi.org/10.1158/1078-0432.22468061
https://doi.org/10.1158/1078-0432.22468061