Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Zhi-Liang Chu"'
Autor:
Khawja A. Usmani, Dawei Yue, Zhi-Liang Chu, Abu J.M. Sadeque, Chris Carroll, Chuan Chen, Hsin-Hui Shu, Sanju Narayanan, Hussein Al-Sharmma, Dominic P. Behan, Robert M. Jones, Graeme Semple, James N. Leonard, David J. Unett, Daniel J. Buzard, Michael Morgan, Juerg Lehmann, Imelda Calderon, Shiu-Feng Tung, Woo Hyun Yoon, Xiuwen Zhu, Sangdon Han, Andrew M. Kawasaki, Amy Siu-Ting Wong, Sun Hee Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3034-3038
The design and optimization of a novel trans-1,4-dioxycyclohexane GPR119 agonist series is described. A lead compound 21 was found to be a potent and efficacious GPR119 agonist across species, and possessed overall favorable pharmaceutical properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f3b9e4db6f1603a99df66761f2f277
https://doi.org/10.1016/j.bmcl.2015.04.102
https://doi.org/10.1016/j.bmcl.2015.04.102
Autor:
Kristen Sebring, Dominic P. Behan, James N. Leonard, Chris Carroll, Annette Lucman, Jinyao Zhou, Charles Xing, Robert M. Jones, David J. Unett, Jean Alfonso, Veronica Gutierrez, Hongmei He, Ruoping Chen, Brandee Wagner, Zhi-Liang Chu
Publikováno v:
Molecular Endocrinology. 24:161-170
G protein-coupled receptor 119 (GPR119) is largely restricted to pancreatic insulin-producing beta-cells and intestinal glucagon-like peptide-1-producing L-cells. Synthetic agonists of this receptor elicit glucose-dependent release of these endocrine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336465d38f95787a87db01093b7487a0
https://doi.org/10.1210/me.2009-0239
https://doi.org/10.1210/me.2009-0239
Publikováno v:
ChemInform. 45
Purine-fused tricyclic derivatives have been synthesized via a copper-catalyzed domino Michael/oxidative cross-coupling reaction between adenines and nitroolefins for the first time. With air as the oxidant, this method has high regioselectivity, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::402604165d3e58ac443f6706d507434d
https://doi.org/10.1002/chin.201429192
https://doi.org/10.1002/chin.201429192
Autor:
Luis Lopez, Daniel J. Buzard, Abu J.M. Sadeque, David J. Unett, Ching-Fen Chuang, Hsin-Hui Shu, Rohit Bhat, James N. Leonard, Sanju Narayanan, Dawei Yue, Robert M. Jones, Amy Siu-Ting Wong, Michael Morgan, Zhi-Liang Chu, Juerg Lehmann, Sun Hee Kim, Hussien A. Al-Shamma, Imelda Calderon, Kevin Whelan, Steve Chang, Shiu-Feng Tung, Tawfik Gharbaoui, Andrew M. Kawasaki, Sangdon Han
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(17)
A series of 5-fluoro-4,6-dialkoxypyrimidine GPR119 modulators were discovered and optimized for in vitro agonist activity. A lead molecule was identified that has improved agonist efficacy relative to our clinical compound (APD597) and possesses redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad2ab4757cddc23a6a0ea787351b612
https://pubmed.ncbi.nlm.nih.gov/25088191
https://pubmed.ncbi.nlm.nih.gov/25088191
Publikováno v:
The Journal of organic chemistry. 79(3)
Purine-fused tricyclic derivatives have been synthesized via a copper-catalyzed domino Michael/oxidative cross-coupling reaction between adenines and nitroolefins for the first time. With air as the oxidant, this method has high regioselectivity, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dca389c99f9d0907a1b501e4344b9a
https://pubmed.ncbi.nlm.nih.gov/24456227
https://pubmed.ncbi.nlm.nih.gov/24456227
Publikováno v:
Journal of Biological Chemistry. 274:15297-15300
The Tax oncoprotein of human T cell leukemia virus type 1 constitutively activates transcription factor NF-kappaB by a mechanism involving Tax-induced phosphorylation of IkappaBalpha, a labile cytoplasmic inhibitor of NF-kappaB. To trigger this signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5709877212c49625cd47bdf63acb0276
https://doi.org/10.1074/jbc.274.22.15297
https://doi.org/10.1074/jbc.274.22.15297
Publikováno v:
Journal of Biological Chemistry. 273:15891-15894
The Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV1) chronically activates transcription factor NF-kappaB by a mechanism involving degradation of IkappaBalpha, an NF-kappaB-associated cytoplasmic inhibitor. Tax-induced breakdown of Ikapp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6255894341c65ab56cccc10f87c6ecdc
https://doi.org/10.1074/jbc.273.26.15891
https://doi.org/10.1074/jbc.273.26.15891
Publikováno v:
Journal of Biological Chemistry. 272:22377-22380
Activation of transcription factor NF-κB involves the signal-dependent degradation of basally phosphorylated inhibitors such as IκBα and IκBβ. The gene encoding IκBα is under NF-κB control, which provides a negative feedback loop to terminate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfaeaac24a36238f84ecaa70b05dda5f
https://doi.org/10.1074/jbc.272.36.22377
https://doi.org/10.1074/jbc.272.36.22377
Publikováno v:
Molecular and Cellular Biology. 16:5974-5984
The product of the c-rel proto-oncogene (c-Rel) belongs to the NF-kappaB/Rel family of polypeptides and has been implicated in the transcriptional control of cell proliferation and immune function. In human T lymphocytes, c-Rel is sequestered in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d545e40960835405158f8aa69dc3db9b
https://doi.org/10.1128/mcb.16.11.5974
https://doi.org/10.1128/mcb.16.11.5974
Publikováno v:
Blood. 84:1992-1999
Erythroid cells express a unique form of beta spectrin I as a result of tissue-specific alternative pre-mRNA processing. Nonerythroid cells that express the beta spectrin I gene include four additional exons at the 3′ end of the mature transcript,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0646f52e7f2bbc37389157414d0cd09
https://doi.org/10.1182/blood.v84.6.1992.1992
https://doi.org/10.1182/blood.v84.6.1992.1992