Zobrazeno 1 - 10
of 429
pro vyhledávání: '"Zhi-Jie Liu"'
Autor:
Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F. DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C. Stevens, Wei Peng, Bryan L. Roth, Zihe Rao, Zhi-Jie Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Hydroxyl-carboxylic acid receptor 2 (HCA2) functions as a high-affinity receptor for nicotinic acid (vitamin B3). Here, authors report the cryo-EM structure of the HCA2-Gi complex with the agonist MK-6892 and inactive state crystal structures of muta
Externí odkaz:
https://doaj.org/article/f2f56268a33144af8505eff4c3edac34
Autor:
Xiaoting Li, Hao Chang, Jara Bouma, Laura V. de Paus, Partha Mukhopadhyay, Janos Paloczi, Mohammed Mustafa, Cas van der Horst, Sanjay Sunil Kumar, Lijie Wu, Yanan Yu, Richard J. B. H. N. van den Berg, Antonius P. A. Janssen, Aron Lichtman, Zhi-Jie Liu, Pal Pacher, Mario van der Stelt, Laura H. Heitman, Tian Hua
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Cannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents in the clinic. Here, authors report the discovery of LEI-102, a CB2R agonist, used in conjunction with three other CBR ligands (APD371, HU308, and CP55,940) to investigat
Externí odkaz:
https://doaj.org/article/4a0327fb90ed454caed0f1b796b69018
Publikováno v:
Asian Journal of Surgery, Vol 46, Iss 9, Pp 3914-3915 (2023)
Externí odkaz:
https://doaj.org/article/6d8d3207bcc147a4ae67e7d8bbedba11
Autor:
Kangsa Amporndanai, Xiaoli Meng, Weijuan Shang, Zhenmig Jin, Michael Rogers, Yao Zhao, Zihe Rao, Zhi-Jie Liu, Haitao Yang, Leike Zhang, Paul M. O’Neill, S. Samar Hasnain
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Ebselen is an organoselenium drug that inhibits the SARS-CoV-2 main protease (Mpro). Here, the authors co-crystallised Mpro with ebselen and an ebselen derivative and observed an enzyme bound organoselenium covalent adduct in the crystal structures,
Externí odkaz:
https://doaj.org/article/8cf917f0f0d94c58998c45d6d9518f5b
Autor:
Bin Li, Li Wang, Zhi-Jie Liu, Feng-min Liu, Yong-hui Yu, Shu-yu Bi, Hai-yan Xu, Chun-yan Yang
Publikováno v:
BMJ Open Quality, Vol 11, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/35b66439d5bc4127ab8df7fe368f5ddf
Autor:
Xiyong Song, Yuejun Shi, Wei Ding, Tongxin Niu, Limeng Sun, Yubei Tan, Yong Chen, Jiale Shi, Qiqi Xiong, Xiaojun Huang, Shaobo Xiao, Yanping Zhu, Chongyun Cheng, Zhen F. Fu, Zhi-Jie Liu, Guiqing Peng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The spike protein of coronaviruses (S-protein) is an envelope-anchored trimeric type I transmembrane glycoprotein that mediates receptor binding and the fusion of the viral and host cell membranes. Here the authors report the conformational states of
Externí odkaz:
https://doaj.org/article/7ffb884ec3014efeb8e143e4317d77ea
Autor:
Hui Li, Jie Yang, Cuiping Tian, Min Diao, Quan Wang, Simeng Zhao, Shanshan Li, Fangzhi Tan, Tian Hua, Ya Qin, Chao-Po Lin, Dylan Deska-Gauthier, Garth J. Thompson, Ying Zhang, Wenqing Shui, Zhi-Jie Liu, Tong Wang, Guisheng Zhong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Despite the importance of G-protein-coupled receptors in many cellular functions, their intracellular organisation is largely unknown. The authors identified periodically repeating clusters of cannabinoid receptor 1 hotspots within neuronal axons tha
Externí odkaz:
https://doaj.org/article/16d642a130464ca1a75800a5fd41828b
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor (GPCR) that is gaining much interest for its regulating role in the central nervous system and its value as a drug target. Structures of CB1 in inactive and active states have revealed conf
Externí odkaz:
https://doaj.org/article/c8bbafe3322c4f76b9de656ed2c53500
Autor:
Jingjing Wang, Meng Wu, Lijie Wu, Yueming Xu, Fei Li, Yiran Wu, Petr Popov, Lin Wang, Fang Bai, Suwen Zhao, Zhi-Jie Liu, Tian Hua
Publikováno v:
IUCrJ, Vol 7, Iss 2, Pp 294-305 (2020)
Human muscarinic receptor M4 belongs to the class A subfamily of the G-protein-coupled receptors (GPCRs). M4 has emerged as an attractive drug target for the treatment of Alzheimer's disease and schizophrenia. Recent results showed that M4-mediated c
Externí odkaz:
https://doaj.org/article/6d59c776379249c4ba811638d8011a9b
Autor:
Bingjie Zhang, Simeng Zhao, Dehua Yang, Yiran Wu, Ye Xin, Haijie Cao, Xi-Ping Huang, Xiaoqing Cai, Wen Sun, Na Ye, Yueming Xu, Yao Peng, Suwen Zhao, Zhi-Jie Liu, Guisheng Zhong, Ming-Wei Wang, Wenqing Shui
Publikováno v:
ACS Central Science, Vol 6, Iss 2, Pp 213-225 (2020)
Externí odkaz:
https://doaj.org/article/f913f83afcbe47449810dd570d7d282f