Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Zhi-Gang Xiong"'
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 507 (2023)
KB-R7943, an isothiourea derivative, is widely used as a pharmacological inhibitor of reverse sodium–calcium exchanger (NCX). It has been shown to have neuroprotective and analgesic effects in animal models; however, the detailed molecular mechanis
Externí odkaz:
https://doaj.org/article/8810e03dd34141bebbcfc76ddd174bf1
Autor:
Mian Xie, Tiandong Leng, Samaneh Maysami, Andrea Pearson, Roger Simon, Zhi-Gang Xiong, Robert Meller
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1214 (2022)
In this study, we characterize biophysical changes in NMDA receptor function in response to brief non-injurious ischemic stress (ischemic preconditioning). Electrophysiological studies show NMDA receptor function is reduced following preconditioning
Externí odkaz:
https://doaj.org/article/3cb47d0b3c104b92ac2e1cbc15fc6112
Autor:
Tiandong Leng, Zhi-Gang Xiong
Publikováno v:
Brain Circulation, Vol 5, Iss 1, Pp 8-11 (2019)
Stroke is a leading cause of death and long-term disabilities. Despite decades of extensive efforts in search of brain injury mechanisms and therapeutic interventions, pharmacological treatment is limited to the use of thrombolytic agent tissue plasm
Externí odkaz:
https://doaj.org/article/48aed439c4ce41d4bcd82aa7c74d019e
Autor:
Yi-Zhi Wang, Jing-Jing Wang, Yu Huang, Fan Liu, Wei-Zheng Zeng, Ying Li, Zhi-Gang Xiong, Michael X Zhu, Tian-Le Xu
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/38c727118a224f78aa75948999a43cc5
Autor:
Yi-Zhi Wang, Jing-Jing Wang, Yu Huang, Fan Liu, Wei-Zheng Zeng, Ying Li, Zhi-Gang Xiong, Michael X Zhu, Tian-Le Xu
Publikováno v:
eLife, Vol 4 (2015)
Acidotoxicity is common among neurological disorders, such as ischemic stroke. Traditionally, Ca2+ influx via homomeric acid-sensing ion channel 1a (ASIC1a) was considered to be the leading cause of ischemic acidotoxicity. Here we show that extracell
Externí odkaz:
https://doaj.org/article/642c42ffb9fb4c1ea170f06a356d0002
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119912 (2015)
Transient receptor potential melastatin 7 (TRPM7), a non-selective cation channel, is highly expressed expressed in the brain and plays a critical role in ischemic neuronal death. Astrocyte, the most abundant cell type in central nervous system (CNS)
Externí odkaz:
https://doaj.org/article/eb7e2da597644387850acdd962f1a299
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79540 (2013)
This study investigated the change of transient receptor potential melastatin 7 (TRPM7) expression by high glucose and its role in hyperglycemia induced injury of vascular endothelial cells. Human umbilical vein endothelial cells (HUVECs) were incuba
Externí odkaz:
https://doaj.org/article/72a9133650fd4b038f93a8002e93140e
Publikováno v:
Stroke (00392499); Jun2024, Vol. 55 Issue 6, p1660-1671, 12p
Publikováno v:
eNeuro; Feb2024, Vol. 11 Issue 2, p1-9, 9p
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:1349-1363
Extracellular proton concentration is at 40 nM when pH is 7.4. In disease conditions such as brain ischemia, proton concentration can reach µM range. To respond to this increase in extracellular proton concentration, the mammalian brain expresses at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d7a9fc799e53516f0538e79d989ec8
https://doi.org/10.1177/0271678x221089074
https://doi.org/10.1177/0271678x221089074