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Autor:
Zhong Liu, Qingjing Hao, Gui-min Zhang, Jinxin Wang, Yanguo Shang, Jing-chun Yao, Wenting Zhang, Jie Li, Zhi Zhuo'er, Yu-shan Ren
Publikováno v:
Journal of medicinal chemistry. 63(11)
Most of the current monoacylglycerol lipase (MAGL) inhibitors function by an irreversible mechanism of action, causing a series of side effects. Herein, starting from irreversible inhibitors, 25 compounds were synthesized and evaluated in vitro for M