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Nucleus of the solitary tract A2 neurons control feeding behaviors via projections to the paraventricular hypothalamus

Autor: Stephanie Murphy, Metika Collis Glynn, Tiarani N. Dixon, Harvey J. Grill, Gavan P. McNally, Zhi Yi Ong

Publikováno v: Neuropsychopharmacology. 48:351-361

Hindbrain NTS neurons are highly attuned to internal physiological and external environmental factors that contribute to the control of food intake but the relevant neural phenotypes and pathways remain elusive. Here, we investigated the role of NTS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1522b7b3e3daf1752cdf654f8f6e831
https://doi.org/10.1038/s41386-022-01448-5

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Glucagon‐Like Peptide‐1 Receptor Signaling in the Ventral Tegmental Area Reduces Alcohol Self‐Administration in Male Rats

Autor: Tiarani N Dixon, Gavan P. McNally, Zhi Yi Ong

Publikováno v: Alcoholism: Clinical and Experimental Research. 44:2118-2129

BACKGROUND The misuse and abuse of alcohol is a major public health issue. However, available treatments are limited with variable efficacy. Recently, preclinical studies show that glucagon-like-peptide-1 (GLP-1) and its analogue Exendin-4 (Ex4) pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b7922facab83709658a5187c002153
https://doi.org/10.1111/acer.14437

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NTS and VTA oxytocin reduces food motivation and food seeking

Autor: Zhi Yi Ong, Matthew R. Hayes, Harvey J. Grill, Anita Kalluri, Hallie S. Wald, Ananya Chandra

Publikováno v: Am J Physiol Regul Integr Comp Physiol

Oxytocin (OT) is a neuropeptide whose central receptor-mediated actions include reducing food intake. One mechanism of its behavioral action is the amplification of the feeding inhibitory effects of gastrointestinal (GI) satiation signals processed b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd59737c7b3286dc8ccc954344cd2c2d
https://pubmed.ncbi.nlm.nih.gov/33026822

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Paraventricular Thalamic Control of Food Intake and Reward: Role of Glucagon-Like Peptide-1 Receptor Signaling

Autor: Harvey J. Grill, Zhi Yi Ong, Jing-Jing Liu, Zhiping P. Pang

Publikováno v: Neuropsychopharmacology. 42:2387-2397

Paraventricular thalamic nucleus (PVT) neurons receive hindbrain and hypothalamic inputs, and project to forebrain sites involved in reward and motivation function. The role of PVT in energy balance and reward control is however understudied. Given t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b1e05438cf1cde2e53d3f268d65909
https://doi.org/10.1038/npp.2017.150

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Central leptin signaling transmits positive valence

Autor: Zhi Yi Ong, Harvey J. Grill, Amber L. Alhadeff, Sineadh M. Conway, Mitchell F. Roitman, Hallie S. Wald

Publikováno v: Brain Res

Hunger resulting from food deprivation is associated with negative affect. This is supported by recent evidence showing that hunger-sensitive neurons drive feeding through a negative valence teaching signal. However, the complementary hypothesis that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dd5b895e5bf14ee77cbb957bc8c0ed
https://pubmed.ncbi.nlm.nih.gov/31513793

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CART in energy balance and drug addiction: Current insights and mechanisms

Autor: Gavan P. McNally, Zhi Yi Ong

Publikováno v: Brain Research. 1740:146852

Cocaine amphetamine related transcript (CART) is a neuropeptide first isolated and sequenced from ovine hypothalamus and later shown to have functions related to drug taking, drug seeking, and energy balance. Here we review the molecular features of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bfcbf8ce97d8ee2dc1457da942a0cf
https://doi.org/10.1016/j.brainres.2020.146852

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Exposure to maternal cafeteria diets during the suckling period has greater effects on fat deposition and Sterol Regulatory Element Binding Protein-1c (SREBP-1c) gene expression in rodent offspring compared to exposure before birth

Autor: Beverly S. Muhlhausler, Jessica R. Gugusheff, Zhi Yi Ong, Simon C. Langley-Evans, Mini A. Vithayathil, Robert A. Gibson

Publikováno v: Nutrition & metabolism, 15:17
Nutrition & Metabolism
Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-15 (2018)

Background: While the adverse metabolic effects of exposure to obesogenic diets during both the prenatal and early postnatal period are well established, the relative impact of exposure during these separate developmental windows remains unclear. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfbcfac1c03ba9e83b9f4b3d859c839
https://hdl.handle.net/11541.2/131140

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