Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Zhi Xiang Xu"'
Autor:
Yuan Zhao, Meng-Jie Liu, Lei Zhang, Qi Yang, Qian-Hui Sun, Jin-Rong Guo, Xin-Yuan Lei, Kai-Yue He, Jun-Qi Li, Jing-Yu Yang, Yong-Ping Jian, Zhi-Xiang Xu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to meet the high energy and biosynthetic demands required for their proliferation. High mobility group A1 (HMGA1) is a structural transcription factor and frequently overe
Externí odkaz:
https://doaj.org/article/4d0d403ebbdf4f05a0d6a47c22faacaa
Autor:
Meng-Jie Liu, Yuan Zhao, Qiu-Tong Li, Xin-Yuan Lei, Kai-Yue He, Jin-Rong Guo, Jing-Yu Yang, Zhen-Hua Yan, Dan-Hui Wu, Lei Zhang, Yong-Ping Jian, Zhi-Xiang Xu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-15 (2024)
Abstract Esophageal squamous cell carcinoma (ESCC) possesses a poor prognosis and treatment outcome. Dysregulated metabolism contributes to unrestricted growth of multiple cancers. However, abnormal metabolism, such as highly activated pentose phosph
Externí odkaz:
https://doaj.org/article/fdcf8b824da241419a86937b0cfaf446
Autor:
Cang Li, Zhengyu Wang, Licheng Yao, Xingyu Lin, Yongping Jian, Yujia Li, Jie Zhang, Jingwei Shao, Phuc D. Tran, James R. Hagman, Meng Cao, Yusheng Cong, Hong-yu Li, Colin R. Goding, Zhi-Xiang Xu, Xuebin Liao, Xiao Miao, Rutao Cui
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Recent development of new immune checkpoint inhibitors has been particularly successfully in cancer treatment, but still the majority patients fail to benefit. Converting resistant tumors to immunotherapy sensitive will provide a significant
Externí odkaz:
https://doaj.org/article/d2b0cc08f5634978acf720d5bf955d80
Autor:
Yujia Li, Wang An, Liyuan Lu, Jiali Yuan, Danhui Wu, Qi Yang, Jinrong Guo, Jingyu Yang, Mengjie Liu, Kaiyue He, Xinyuan Lei, Zhi-Xiang Xu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background O-GlcNAcylation modification affects multiple physiological and pathophysiolocal functions of cells. Altered O-GlcNAcylation was reported to participate in antivirus response. Stimulator of interferon genes (STING) is an adaptor m
Externí odkaz:
https://doaj.org/article/e7142f89d0a74c7384254913a5917236
Autor:
Guangtao Li, Hongxia Yang, Dan Zhang, Yanghe Zhang, Bin Liu, Yuxiong Wang, Honglan Zhou, Zhi-Xiang Xu, Yishu Wang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117079- (2024)
Macrophages are widely distributed throughout various tissues of the body, and mounting evidence suggests their involvement in regulating the tissue microenvironment, thereby influencing disease onset and progression through direct or indirect action
Externí odkaz:
https://doaj.org/article/87612f65e8bd44b383d99a4522600da1
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Maintaining the structural integrity of genomic chromosomal DNA is an essential role of cellular life and requires two important biological mechanisms: the DNA damage response (DDR) mechanism and telomere protection mechanism at chromosome ends. Beca
Externí odkaz:
https://doaj.org/article/1a159fc4f47f4bf0bb23db8b5f6cac01
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116643- (2024)
Accumulated alterations in metabolic control provide energy and anabolic demands for enhanced cancer cell proliferation. Exemplified by the Warburg effect, changes in glucose metabolism during cancer progression are widely recognized as a characteris
Externí odkaz:
https://doaj.org/article/cf5a9816d3a24d06b1d15af627cfbeca
Autor:
Jing-Yu Yang, Xin-Yuan Lei, Kai-Yue He, Jin-Rong Guo, Meng-Jie Liu, Jun-Qi Li, Qiu-Tong Li, Zhi-Hao Jiang, Lei Zhang, Dan-Hui Wu, Yu-Jia Li, Qian-Hui Sun, Yong-Ping Jian, Zhi-Xiang Xu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-16 (2024)
Abstract Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs is an important hurdle to effective treatment. Understanding the mechanisms underlying chemotherapy resistance in ESCC is
Externí odkaz:
https://doaj.org/article/d9895485b3a64bd58022048ca442b56f
Autor:
Mingdi Liu, Yuning Zhang, Yongping Jian, Liting Gu, Dan Zhang, Honglan Zhou, Yishu Wang, Zhi-Xiang Xu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gen
Externí odkaz:
https://doaj.org/article/7918eb6cd3624896afb8fbe2b512d213
Autor:
Qingfei Meng, Huihui Sun, Yanghe Zhang, Xiangzhe Yang, Shiming Hao, Bin Liu, Honglan Zhou, Zhi-Xiang Xu, Yishu Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-19 (2024)
Abstract Background Discoidin, CUB, and LCCL domain-containing type I (DCBLD1) is identified as an oncogene involved in multiple regulation of tumor progression, but specific mechanisms remain unclear in cervical cancer. Lactate-mediated lactylation
Externí odkaz:
https://doaj.org/article/154fd26c36004ebcb570c8d37b24fdbe