Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Zhi Ren Zhang"'
Autor:
Ming‐Ming Wu, Yan‐Chao Yang, Yong‐Xu Cai, Shuai Jiang, Han Xiao, Chang Miao, Xi‐Yun Jin, Yu Sun, Xin Bi, Zi Hong, Di Zhu, Miao Yu, Jian‐Jun Mao, Chang‐Jiang Yu, Chen Liang, Liang‐Liang Tang, Qiu‐Shi Wang, Qun Shao, Qing‐Hua Jiang, Zhen‐Wei Pan, Zhi‐Ren Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract The risk for suffering immune checkpoint inhibitors (ICIs)‐associated myocarditis increases in patients with pre‐existing conditions and the mechanisms remain to be clarified. Spatial transcriptomics, single‐cell RNA sequencing, and fl
Externí odkaz:
https://doaj.org/article/f762988008d54502959e5c209199f42f
Autor:
Ming-Luan Zhao, Chen Liang, Wei-Wei Jiang, Mei Zhang, Hong Guan, Zi Hong, Di Zhu, An-Qi Shang, Chang-Jiang Yu, Zhi-Ren Zhang
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37278- (2024)
Objective: Though an increased risk of atherosclerosis is associated with anti-CTLA-4 antibody therapy, the underlying mechanisms remain unclear. Methods: C57BL/6 mice were treated with anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) antibo
Externí odkaz:
https://doaj.org/article/2436e1e5809e4b488891c6982a371267
Autor:
Liang-Liang Tang, Xu Yang, Shu-Qi Yu, Qi Qin, Rong Xue, Yu Sun, Han Xiao, An-Qi Shang, Jia-Qun Liu, Song-Qi Han, Chen Liang, Jie Lou, Qiu-Shi Wang, Chang-Jiang Yu, Ming-Ming Wu, Zhi-Ren Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Previous studies have demonstrated that activated endothelial epithelial sodium channel (EnNaC) impairs vasodilatation, which contributes to salt-sensitive hypertension. Here, we investigate whether mesenteric artery (MA) EnNaC is involve
Externí odkaz:
https://doaj.org/article/50b83b65f87e48d3b4da752385de261d
Autor:
Shanshan Luo, Chuiyu Kong, Shuang Zhao, Xin Tang, Yu Wang, Xuechun Zhou, Rui Li, Xingeng Liu, Xinlong Tang, Shixiu Sun, Wei Xie, Zhi-Ren Zhang, Qing Jing, Aihua Gu, Feng Chen, Dongjin Wang, Hong Wang, Yi Han, Liping Xie, Yong Ji
Publikováno v:
Circulation. 147:1382-1403
Background: Aortic aneurysm and aortic dissection (AAD) are life-threatening vascular diseases, with endothelium being the primary target for AAD treatment. Protein S-sulfhydration is a newly discovered posttranslational modification whose role in AA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4751fff1e0504863ac6b13bc8fb75fc
https://doi.org/10.1161/circulationaha.122.062743
https://doi.org/10.1161/circulationaha.122.062743
Autor:
Chen Liang, Qiu-Shi Wang, Xu Yang, Di Zhu, Yu Sun, Na Niu, Jie Yao, Bi-Han Dong, Shuai Jiang, Liang-Liang Tang, Jie Lou, Chang-Jiang Yu, Qun Shao, Ming-Ming Wu, Zhi-Ren Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
BackgroundHyperhomocysteinemia (HHcy) causes cardiovascular diseases via regulating inflammatory responses. We investigated whether and how the epithelial sodium channel (ENaC), a recently identified ion channel in endothelial cells, plays a role in
Externí odkaz:
https://doaj.org/article/b3379b58c6a74932ba3112b43f65a8f2
Autor:
Yong-Xu Cai, Bao-Long Zhang, Miao Yu, Yan-Chao Yang, Xue Ao, Di Zhu, Qiu-Shi Wang, Jie Lou, Chen Liang, Liang-Liang Tang, Ming-Ming Wu, Zhi-Ren Zhang, He-Ping Ma
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
We have shown that cholesterol regulates the activity of ion channels in mouse cortical collecting duct (CCD) mpkCCDc14 cells and that the transient receptor potential melastatin 4 (TRPM4) channel is expressed in these cells. However, whether TRPM4 c
Externí odkaz:
https://doaj.org/article/a488d6fafc37435190f74649a7756374
Autor:
Qiu-Shi Wang, Chen Liang, Shuai Jiang, Di Zhu, Yu Sun, Na Niu, Xu Yang, Yan-Chao Yang, Bi-Han Dong, Jie Yao, Chang-Jiang Yu, Jie Lou, Liang-Liang Tang, Ming-Ming Wu, Zhi-Ren Zhang, He-Ping Ma
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The use of cyclosporine A (CsA) in transplant recipients is limited due to its side effects of causing severe hypertension. We have previously shown that CsA increases the activity of the epithelial sodium channel (ENaC) in cultured distal nephron ce
Externí odkaz:
https://doaj.org/article/aa9bcbbf23bd4489a7bc642cfc0eafd9
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Antiangiogenic tyrosine kinases inhibitors induce hypertension, which may increase the incidents of cardiovascular complications and limit their use. However, the mechanisms by which usage of TKIs results in hypertension have not been fully understoo
Externí odkaz:
https://doaj.org/article/dd014d3508f84cdb826ad3a9217a62f6
Autor:
Yu-Jia Zhai, Bing-Chen Liu, Shi-Peng Wei, Chu-Fang Chou, Ming-Ming Wu, Bin-Lin Song, Valerie A. Linck, Li Zou, Shuai Zhang, Xue-Qi Li, Zhi-Ren Zhang, He-Ping Ma
Publikováno v:
Cellular Physiology and Biochemistry, Vol 47, Iss 3, Pp 1051-1059 (2018)
Background/Aims: The epithelial sodium channel (ENaC) in cortical collecting duct (CCD) principal cells plays a critical role in regulating systemic blood pressure. We have previously shown that cholesterol (Cho) in the apical cell membrane regulates
Externí odkaz:
https://doaj.org/article/dfaf7a60b0324aaab53855043374ac19
Autor:
Xiao-Qing Ding, Tao Ban, Zeng-Yan Liu, Jie Lou, Liang-Liang Tang, Jia-Xin Wang, Wen-Feng Chu, Dan Zhao, Bin-Lin Song, Zhi-Ren Zhang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 41, Iss 2, Pp 835-848 (2017)
Background/Aims: The present study investigated whether the transient receptor potential melastatin 4 (TRPM4) channel plays a role in high salt diet (HSD)-induced endothelial injuries. Methods: Western blotting and immunofluorescence were used to exa
Externí odkaz:
https://doaj.org/article/4023d5ab78ed4a7bb7be5dd4c1ec10ad