Zobrazeno 1 - 10
of 577
pro vyhledávání: '"Zhi Jun Sun"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3416-3431 (2024)
Chimeric antigen receptor T (CAR-T) cell therapy as a form of adoptive cell therapy (ACT) has shown significant promise in cancer treatment, demonstrated by the FDA-approved CAR-T cell therapies targeting CD19 or B cell maturation antigen (BCMA) for
Externí odkaz:
https://doaj.org/article/23b2769e78eb4b40801da3099fe14e7d
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105420- (2024)
Summary: Pyroptosis, a type of programmed cell death mediated by gasdermin family proteins, releases a large amount of immune stimulatory substances, which further contribute to inflammation and elicit an adaptive immune response against tumours and
Externí odkaz:
https://doaj.org/article/73d1c4f5650846b9992f8857529a53b9
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background As the global aging process continues to accelerate, heart failure (HF) has become an important cause of increased morbidity and mortality in elderly patients. Chronic atrial fibrillation (AF) is a major risk factor for HF. Patien
Externí odkaz:
https://doaj.org/article/68a155abc1564f1189574891887c78f6
Autor:
Shuo Wang, An Song, Jun Xie, Yuan-Yuan Wang, Wen-Da Wang, Meng-Jie Zhang, Zhi-Zhong Wu, Qi-Chao Yang, Hao Li, Junjie Zhang, Zhi-Jun Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Oncolytic viruses (OVs) show promise as a cancer treatment by selectively replicating in tumor cells and promoting antitumor immunity. However, the current immunogenicity induced by OVs for tumor treatment is relatively weak, necessitating a
Externí odkaz:
https://doaj.org/article/8b1156f4d3ba4a21b6f85271b03900a9
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105154- (2024)
Summary: Immune therapies represented by immune checkpoint blockade (ICB) have significantly transformed cancer treatment. However, the effectiveness of these treatments depends on the status of T cells. T cell exhaustion, characterized by diminished
Externí odkaz:
https://doaj.org/article/979eafce118f4090b3a309992fff0d43
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundThe electromechanical dyssynchrony associated with right ventricular pacing (RVP) has been found to have adverse impact on clinical outcomes. Several studies have shown that left bundle branch area pacing (LBBAP) has superior pacing paramet
Externí odkaz:
https://doaj.org/article/0f6e15b33f824c5f96e1575753d042b7
Publikováno v:
Military Medical Research, Vol 10, Iss 1, Pp 1-24 (2023)
Abstract Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of CD8+ tumor-infiltrating lymphocytes (TILs), which is termed T
Externí odkaz:
https://doaj.org/article/e63043ae2e154af6a2841677d1fd83cc
Autor:
Liang Zhang, An Song, Qi-Chao Yang, Shu-Jin Li, Shuo Wang, Shu-Cheng Wan, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam, Hexiang Deng, Ben Zhong Tang, Zhi-Jun Sun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Immunogenic programmed cell death, such as pyroptosis and ferroptosis, efficiently induces an acute inflammatory response and boosts antitumor immunity. However, the exploration of dual-inducers, particularly nonmetallic inducers, capable of
Externí odkaz:
https://doaj.org/article/27e34f63e59949f894cba2fc41fe9ae4
Autor:
Jun Xie, Shaowei Wang, Yunhong Zhong, Ming Gao, Xuezhang Tian, Liting Zhang, Dongli Pan, Qingsong Qin, Bing Wu, Ke Lan, Zhi-Jun Sun, Junjie Zhang
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 61-76 (2023)
Oncolytic viruses (OVs) encoding various transgenes are being evaluated for cancer immunotherapy. Diverse factors such as cytokines, immune checkpoint inhibitors, tumor-associated antigens, and T cell engagers have been exploited as transgenes. These
Externí odkaz:
https://doaj.org/article/623e5979b18a480f934fa23257207744
Autor:
Biao Huang, Tao Tang, Shi-Hui Chen, Hao Li, Zhi-Jun Sun, Zhi-Lin Zhang, Mingxi Zhang, Ran Cui
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Monitoring the status of blood-brain barrier (BBB) and inhibiting reactive oxygen species (ROS)-mediated oxidative damage are key issues in the treatment of traumatic brain injury (TBI). Here, the authors design a near-infrared-IIb emitting Mn single
Externí odkaz:
https://doaj.org/article/dc8df595606c41a3825fec4587c8499c