Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Zhi Dong Zhou"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Passive immunotherapy with specific antibodies targeting Amyloid β (Aβ) peptide or tubulin-associated unit (tau) protein has emerged as a promising therapeutic approach in Alzheimer’s disease (AD). However, in a recent phase III clinical
Externí odkaz:
https://doaj.org/article/20bd9b6e59364637ba67ec11e9fc2554
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-15 (2023)
Abstract A pathological feature of Parkinson’s disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. DA is the neurotransmitter of dopaminergic neurons.
Externí odkaz:
https://doaj.org/article/d7b697b1bad04173b3a5981563d55714
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4643 (2024)
There are currently no disease-modifying therapies for Parkinson’s disease (PD), a progressive neurodegenerative disorder associated with dopaminergic neuronal loss. There is increasing evidence that endogenous dopamine (DA) can be a pathological f
Externí odkaz:
https://doaj.org/article/67945472661c456f8ac062537323306a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13721 (2023)
Neurodegenerative diseases are characterized by the progressive degeneration or death of neurons in the central or peripheral nervous system [...]
Externí odkaz:
https://doaj.org/article/7ac82956f9b24aea952c7275b17131b1
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/5a8fc26a636a4583aa057532b4b45ebc
Publikováno v:
Translational Neurodegeneration, Vol 8, Iss 1, Pp 1-14 (2019)
Abstract Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, which is characterized by the progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta concomitant with Lewy body formation in affected
Externí odkaz:
https://doaj.org/article/c09533ad22ca45c19a7dde978a434d37
Autor:
Zhi Dong Zhou, Eng-King Tan
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-12 (2017)
Abstract The homeostasis of iron is vital to human health, and iron dyshomeostasis can lead to various disorders. Iron homeostasis is maintained by iron regulatory proteins (IRP1 and IRP2) and the iron-responsive element (IRE) signaling pathway. IRPs
Externí odkaz:
https://doaj.org/article/4f2fa7b979db47bd8e0b1731fb2528a8
Autor:
Zhi Dong Zhou, Shao Ping Xie, Wuan Ting Saw, Patrick Ghim Hoe Ho, Hong Yan Wang, Lei Zhou, Yi Zhao, Eng King Tan
Publikováno v:
Cells, Vol 8, Iss 8, p 911 (2019)
Accumulative evidence indicated that the pathologically accumulated metal ions (iron species and Mn3+) and abnormally up-regulated monoamine oxidase B (MAOB) activity induced oxidation of endogenous dopamine (DA) can lead to mitochondria impairment,
Externí odkaz:
https://doaj.org/article/cf5f1a0a519c46a884f5665529f4eb61
Autor:
Yin Xia Chao, Ebonne Yu Lin Ng, Huihua Li, Kandiah Nagaendran, Yuen Yih, Mei Sian Chong, Kumar M. Prakash, Louis Tan, Wing Lok Au, Yi Zhao, Zhi Dong Zhou, Murni Tio, Ratnagopal Pavanni, Eng King Tan
Publikováno v:
Parkinson's Disease, Vol 2015 (2015)
Objective. COQ2 mutations have been reported in Japanese multiple system atrophy (MSA) patients. We examined the role of COQ2 in patients with dementia and essential tremor (ET), two common neurodegenerative conditions. Materials & Methods. A total o
Externí odkaz:
https://doaj.org/article/4b9cdc49ba1b441eba853a2dc0ddca30
Publikováno v:
Landslides. 19:2535-2538