Zobrazeno 1 - 10
of 320
pro vyhledávání: '"Zhi‐Shu Huang"'
Autor:
Jun-Yunzi Wu, Long-Ling Huang, Jia-Luo Fu, Jia-Yi Li, Shuang Lin, Shuang Yang, Zhi-Shu Huang, Honggen Wang, Qingjiang Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Both the pyrroloindoline core and N–CF3 moiety hold significant importance in medicinal chemistry. However, to date, no instances of constructing N–CF3-containing pyrroloindolines have been reported. Herein, we present a robust and opera
Externí odkaz:
https://doaj.org/article/c2f779f2c1d84c99a1b19e35f7edd985
Autor:
Yin Li, Zhi‐Hao Chen, Shuang Lin, Yuan Liu, Jiasheng Qian, Qingjiang Li, Zhi‐Shu Huang, Honggen Wang
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Electrophilic addition reaction to alkynes is of fundamental importance in organic chemistry, yet the regiocontrol when reacting with unsymmetrical 1,2‐dialkyl substituted alkynes is often problematic. Herein, it is demonstrated that the r
Externí odkaz:
https://doaj.org/article/77a492a0b79d45a38ffcbbada6fbb9e4
Publikováno v:
Molecules, Vol 28, Iss 14, p 5598 (2023)
MSN8C, an analog of mansonone E, has been identified as a novel catalytic inhibitor of human DNA topoisomerase II that induces tumor regression and differs from VP-16(etoposide). Treatment with MSN8C showed significant antiproliferative activity agai
Externí odkaz:
https://doaj.org/article/c0863f1cca36440f8b5b54c87cada5ed
Publikováno v:
Pharmacological Research, Vol 177, Iss , Pp 106136- (2022)
Promoting energy expenditure is known to curb obesity and can be exploited for its treatment. Our previous study has demonstrated that activation of HSF1/PGC-1α axis efficiently induced mitochondrial biogenesis and adaptive oxidation and thus amelio
Externí odkaz:
https://doaj.org/article/f2bae8a60dc247b2b29bbdcab3a398f8
Autor:
Bo-Zheng Wang, Ying-Chen Zhou, Yu-Wei Lin, Xiu-Cai Chen, Ze-Yi Yu, Yao-Hao Xu, Jia-Heng Tan, Zhi-Shu Huang, Shuo-Bin Chen
Publikováno v:
Molecules, Vol 28, Iss 6, p 2690 (2023)
Mitochondria have a crucial role in regulating energy metabolism and their dysfunction has been linked to tumorigenesis. Cancer diagnosis and intervention have a great interest in the development of new agents that target biomolecules within mitochon
Externí odkaz:
https://doaj.org/article/8878e8f93cc4401a8ba71e24843c8a4c
Autor:
Lan Fang, Wen Shao, Shu-Tang Zeng, Gui-Xue Tang, Jia-Tong Yan, Shuo-Bin Chen, Zhi-Shu Huang, Jia-Heng Tan, Xiu-Cai Chen
Publikováno v:
Molecules, Vol 27, Iss 20, p 6927 (2022)
RNA imaging is of great importance for understanding its complex spatiotemporal dynamics and cellular functions. Considerable effort has been devoted to the development of small-molecule fluorescent probes for RNA imaging. However, most of the report
Externí odkaz:
https://doaj.org/article/e26679f51e3b4d41955d0d202606a7eb
Autor:
Xin Pan, Teng-yu Mao, Yan-wen Mai, Cheng-cheng Liang, Wei-hao Huang, Yong Rao, Zhi-shu Huang, Shi-liang Huang
Publikováno v:
Molecules, Vol 27, Iss 17, p 5561 (2022)
Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library and kinase lib
Externí odkaz:
https://doaj.org/article/d57ae07bd94249d987c71b314455d0d3
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 439-447 (2016)
Environments surrounding G-rich sequences remarkably affect the conformations of these structures. A proper evaluation system mimicking the crowded environment in a cell with macromolecules should be developed to perform structural and functional stu
Externí odkaz:
https://doaj.org/article/91ce7703a2b149d5b3558cb87662fd4d
Autor:
Yun-Xia Xiong, Ai-Chun Chen, Pei-Fen Yao, De-Ying Zeng, Yu-Jing Lu, Jia-Heng Tan, Zhi-Shu Huang, Tian-Miao Ou
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 346-352 (2016)
At present, wt1, a Wilms’ tumor suppressor gene, is recognized as a critical regulator of tumorigenesis and a potential therapeutic target. WT1 shows the ability to regulate the transcription of bcl-2 by binding to a GC-rich region in the promoter,
Externí odkaz:
https://doaj.org/article/2d3ff17de6274d4c82612f3924c1a30b
Publikováno v:
Molecules, Vol 23, Iss 2, p 493 (2018)
G-quadruplexes are four-stranded nucleic acid secondary structures that are formed in guanine-rich sequences. G-quadruplexes are widely distributed in functional regions of the human genome and transcriptome, such as human telomeres, oncogene promote
Externí odkaz:
https://doaj.org/article/a0c7aff3139241c2ba571a6fd7228613