Zobrazeno 1 - 10
of 422
pro vyhledávání: '"Zhi‐Shu Huang"'
Autor:
Jun-Yunzi Wu, Long-Ling Huang, Jia-Luo Fu, Jia-Yi Li, Shuang Lin, Shuang Yang, Zhi-Shu Huang, Honggen Wang, Qingjiang Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Both the pyrroloindoline core and N–CF3 moiety hold significant importance in medicinal chemistry. However, to date, no instances of constructing N–CF3-containing pyrroloindolines have been reported. Herein, we present a robust and opera
Externí odkaz:
https://doaj.org/article/c2f779f2c1d84c99a1b19e35f7edd985
Autor:
Yin Li, Zhi‐Hao Chen, Shuang Lin, Yuan Liu, Jiasheng Qian, Qingjiang Li, Zhi‐Shu Huang, Honggen Wang
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Electrophilic addition reaction to alkynes is of fundamental importance in organic chemistry, yet the regiocontrol when reacting with unsymmetrical 1,2‐dialkyl substituted alkynes is often problematic. Herein, it is demonstrated that the r
Externí odkaz:
https://doaj.org/article/77a492a0b79d45a38ffcbbada6fbb9e4
Publikováno v:
Molecules, Vol 28, Iss 14, p 5598 (2023)
MSN8C, an analog of mansonone E, has been identified as a novel catalytic inhibitor of human DNA topoisomerase II that induces tumor regression and differs from VP-16(etoposide). Treatment with MSN8C showed significant antiproliferative activity agai
Externí odkaz:
https://doaj.org/article/c0863f1cca36440f8b5b54c87cada5ed
Publikováno v:
Pharmacological Research, Vol 177, Iss , Pp 106136- (2022)
Promoting energy expenditure is known to curb obesity and can be exploited for its treatment. Our previous study has demonstrated that activation of HSF1/PGC-1α axis efficiently induced mitochondrial biogenesis and adaptive oxidation and thus amelio
Externí odkaz:
https://doaj.org/article/f2bae8a60dc247b2b29bbdcab3a398f8
Autor:
Bo-Zheng Wang, Ying-Chen Zhou, Yu-Wei Lin, Xiu-Cai Chen, Ze-Yi Yu, Yao-Hao Xu, Jia-Heng Tan, Zhi-Shu Huang, Shuo-Bin Chen
Publikováno v:
Molecules, Vol 28, Iss 6, p 2690 (2023)
Mitochondria have a crucial role in regulating energy metabolism and their dysfunction has been linked to tumorigenesis. Cancer diagnosis and intervention have a great interest in the development of new agents that target biomolecules within mitochon
Externí odkaz:
https://doaj.org/article/8878e8f93cc4401a8ba71e24843c8a4c
Autor:
Lan Fang, Wen Shao, Shu-Tang Zeng, Gui-Xue Tang, Jia-Tong Yan, Shuo-Bin Chen, Zhi-Shu Huang, Jia-Heng Tan, Xiu-Cai Chen
Publikováno v:
Molecules, Vol 27, Iss 20, p 6927 (2022)
RNA imaging is of great importance for understanding its complex spatiotemporal dynamics and cellular functions. Considerable effort has been devoted to the development of small-molecule fluorescent probes for RNA imaging. However, most of the report
Externí odkaz:
https://doaj.org/article/e26679f51e3b4d41955d0d202606a7eb
Autor:
Xin Pan, Teng-yu Mao, Yan-wen Mai, Cheng-cheng Liang, Wei-hao Huang, Yong Rao, Zhi-shu Huang, Shi-liang Huang
Publikováno v:
Molecules, Vol 27, Iss 17, p 5561 (2022)
Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library and kinase lib
Externí odkaz:
https://doaj.org/article/d57ae07bd94249d987c71b314455d0d3
Autor:
Tian-Ying Wu, Xiu-Cai Chen, Gui-Xue Tang, Wen Shao, Zhang-Chi Li, Shuo-Bin Chen, Zhi-Shu Huang, Jia-Heng Tan
Publikováno v:
Journal of Medicinal Chemistry. 66:5484-5499
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3d411f47f7af64708a0be1f4143aa08
https://doi.org/10.1021/acs.jmedchem.2c01808
https://doi.org/10.1021/acs.jmedchem.2c01808
Autor:
Xue-Long Yan, Yue-Hua Pan, Run-Zhu Fan, Qin-Qin Song, Shen Li, Jia-Luo Huang, Wei Li, Dong Huang, Fang-Yu Yuan, Gui-Hua Tang, Yong Rao, Zhi-Shu Huang, Sheng Yin
Publikováno v:
Journal of Medicinal Chemistry. 66:5839-5858
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7655702bd7d933838b59d4823e9b3680
https://doi.org/10.1021/acs.jmedchem.3c00067
https://doi.org/10.1021/acs.jmedchem.3c00067
Autor:
Xiu-Cai Chen, Gui-Xue Tang, Jing Dai, Le-Tian Dai, Tian-Ying Wu, Wen-Wei Li, Tian-Miao Ou, Zhi-Shu Huang, Jia-Heng Tan, Shuo-Bin Chen
Publikováno v:
Journal of Medicinal Chemistry. 66:5171-5184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::530a8caaf44c79f76a83392afcd96a89
https://doi.org/10.1021/acs.jmedchem.3c00094
https://doi.org/10.1021/acs.jmedchem.3c00094