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Phase 2 study of tislelizumab monotherapy in previously treated, locally advanced, unresectable or metastatic microsatellite instability-high/mismatch repair-deficient solid tumors: Gynecological cancer subgroup (127)

Autor: Dong Wang, Naiyi Zhang, Aimin Zang, Jing Wang, Yi Huang, Lin Shen, Jian Li, Yanqiao Zhang, Tianshu Liu, Yanhong Deng, Yaling Xu, Zhezhen Li, Yidi Wang, Yunong Gao

Publikováno v: Gynecologic Oncology. 166:S80-S81

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d6887ac53c4218b817e42855a656f1a
https://doi.org/10.1016/s0090-8258(22)01353-1

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A phase 2 study of tislelizumab monotherapy in patients with previously treated, locally advanced unresectable ormetastatic microsatellite instability-high/mismatch repair deficient solid tumors

Publikováno v: Journal of Clinical Oncology. 39:2569-2569

2569 Background: Tislelizumab is an anti-programmed cell death protein 1 antibody engineered to minimize binding to FcγR on macrophages to abrogate antibody-dependent phagocytosis. In early phase clinical studies, tislelizumab monotherapy was genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15e5dba7c20d1d0adca3f17963f2f95d
https://doi.org/10.1200/jco.2021.39.15_suppl.2569

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Bgb-A425, an investigational anti-TIM-3 monoclonal antibody, in combination with tislelizumab, an anti-PD-1 monoclonal antibody, in patients with advanced solid tumors: A phase I/II trial in progress

Autor: ZheZhen Li, Crystal S. Denlinger, Song Mu, Jayesh Desai, Wells A. Messersmith, Tarek Meniawy, Brandon R. Beagle, John Wu

Publikováno v: Journal of Clinical Oncology. 38:TPS3146-TPS3146

TPS3146 Background: While immune surveillance plays a critical role in preventing tumor proliferation and metastasis, tumors develop resistance mechanisms to suppress and/or escape the immune system. T-cell immunoglobulin and mucin-domain containing-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03a1f484aaf4a25b495c44d1dfa208db
https://doi.org/10.1200/jco.2020.38.15_suppl.tps3146

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Fatigue behaviour of nozzle corner cracks

Autor: Qichao Hong, Guozhong Chai, Zhezhen Li

Publikováno v: Engineering Fracture Mechanics. 37:661-666

In the present paper, the fatigue propagation of nozzle corner cracks is experimentally researched through nine pieces of plate-nozzle models and a large pressure vessel ( D = 1000 × 4500 mm ) with five nozzles. The experimental results show that th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89ce9673ff7531c9619b1af97c56b837
https://doi.org/10.1016/0013-7944(90)90388-w

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