Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Zheqing Cai"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Migraine affects ∼15% of the adult population, and the standard treatment includes the use of triptans, ergotamines, and analgesics. Recently, CGRP and its receptor, the CLR/RAMP1 receptor complex, have been targeted for migraine treatment due to t
Externí odkaz:
https://doaj.org/article/3c605d72a07b43ce8042c757c1c924e9
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13408 (2022)
Background: Adrenomedullin (ADM), adrenomedullin 2 (ADM2), and CGRP family peptides are important regulators of vascular vasotone and integrity, neurotransmission, and fetoplacental development. These peptides signal through CLR/RAMP1, 2, and 3 recep
Externí odkaz:
https://doaj.org/article/ac2785eceaea4820a4d323623ac57711
Autor:
Ankit X. Sharma, Ezekiel B. Quittner-Strom, Young Lee, Joshua A. Johnson, Sarah A. Martin, Xinxin Yu, Jianping Li, John Lu, Zheqing Cai, Shiuhwei Chen, May-yun Wang, Yiyi Zhang, Mackenzie J. Pearson, Andie C. Dorn, Jeffrey G. McDonald, Ruth Gordillo, Hai Yan, Dung Thai, Zhao V. Wang, Roger H. Unger, William L. Holland
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1760-1773 (2018)
Summary: The antidiabetic potential of glucagon receptor antagonism presents an opportunity for use in an insulin-centric clinical environment. To investigate the metabolic effects of glucagon receptor antagonism in type 2 diabetes, we treated Leprdb
Externí odkaz:
https://doaj.org/article/fc9dc67502904242b84786c20471f0be
Publikováno v:
Journal of Hypertension.
Autor:
Shuxun Ren, Hai Yan, Yibin Wang, Zheqing Cai, Cunyu Zeng, Dung Thai, Junyi Yu, John Lu, Chen Gao
Publikováno v:
Circulation Research. 123
Glucagon is an important hormone for glycemic control with counter-balancing function vs. insulin, and treatment of glucagon receptor antibody is shown to be efficacious for type I and type II diabetes. It was reported recently that systemic treatmen
Autor:
Zheqing Cai, Ashley Cai
Publikováno v:
The FASEB Journal. 32
Autor:
Ruth Gordillo, William L. Holland, Young H Lee, Sarah A. Martin, Xinxin Yu, Jianping Li, Dung Thai, Joshua A. Johnson, Roger H Unger, Jeffrey G. McDonald, Mackenzie J. Pearson, John Lu, May-Yun Wang, Ezekiel B. Quittner-Strom, Zhao V. Wang, Yiyi Zhang, Shiuhwei Chen, Andie C. Dorn, Zheqing Cai, Ankit X. Sharma, Hai Yan
Publikováno v:
Cell reports
Cell Reports, Vol 22, Iss 7, Pp 1760-1773 (2018)
Cell Reports, Vol 22, Iss 7, Pp 1760-1773 (2018)
SUMMARY The antidiabetic potential of glucagon receptor antagonism presents an opportunity for use in an insulin-centric clinical environment. To investigate the metabolic effects of glucagon receptor antagonism in type 2 diabetes, we treated Leprdb/
Autor:
Medha S. Darshan, Rigu Gupta, Zheqing Cai, Frank J. Gonzalez, Kakali Sarkar, Gregg L. Semenza, Karen Fox-Talbot, Nirmal Parajuli
Publikováno v:
Proceedings of the National Academy of Sciences. 109:10504-10509
Infarction occurs when myocardial perfusion is interrupted for prolonged periods of time. Short episodes of ischemia and reperfusion protect against tissue injury when the heart is subjected to a subsequent prolonged ischemic episode, a phenomenon kn
Autor:
Marta Bosch-Marce, Gregg L. Semenza, Michael A. Trush, Hua Zhong, Lei Wang, Chiming Wei, Zheqing Cai, Karen Fox-Talbot
Publikováno v:
Cardiovascular Research. 77:463-470
Aims We investigated whether hypoxia-inducible factor 1α (HIF-1α) plays a role in the acute phase of ischaemic preconditioning (IPC). Methods and results Hearts from wild-type (WT) mice and mice heterozygous for a null allele at the locus encoding
Autor:
Zheqing Cai, Gregg L. Semenza
Publikováno v:
Circulation Research. 97:1351-1359
Ischemic preconditioning (IPC), a brief period of ischemia and reperfusion (I/R), generates profound but transient protection against a subsequent prolonged ischemic episode. The serine-threonine kinase Akt has been shown to mediate IPC, and Akt acti