The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein

Autor: Lanqin Wu, Yingying Lin, Jinan Feng, Yuanlin Qi, Xinrui Wang, Qiaofa Lin, Wanyan Shi, Enrun Zheng, Wei Wang, Zhenzhu Hou, Hanbin Lin, Cheng Yu, Yan He, Yan Xu, Hong Yang, Ling Lin, Lisheng Li

Publikováno v: Cancer Cell International, Vol 19, Iss 1, Pp 1-11 (2019)

Abstract Background Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis. MCL1 is a fast-turnover protein that is degraded via an ubiquit

Externí odkaz: https://doaj.org/article/6eec4a7e3a2541e58db7b0c14e20f195

Regulation of survivin protein stability by USP35 is evolutionarily conserved

Autor: Jinan Feng, Zhenzhu Hou, Hanbin Lin, Enrun Zheng, Wenyang Huang, Lisheng Li, Jingyi Li, Wei Wang, Danni Chen, Yuanyuan Liu

Publikováno v: Biochemical and biophysical research communications. 574

Survivin is the key component of the chromosomal passenger complex and plays important roles in the regulation of cell division. Survivin has also been implicated in the regulation of apoptosis and tumorigenesis. Although the survivin protein has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a329b40f75a85023f27ec2a1efe1ceba
https://pubmed.ncbi.nlm.nih.gov/34438346

MOESM1 of The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein

Autor: Lanqin Wu, Yingying Lin, Feng, Jinan, Yuanlin Qi, Xinrui Wang, Qiaofa Lin, Wanyan Shi, Enrun Zheng, Wang, Wei, Zhenzhu Hou, Hanbin Lin, Yu, Cheng, He, Yan, Xu, Yan, Yang, Hong, Lin, Ling, Lisheng Li

Additional file 1. Additional figures.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38411d687543e6e08e230aebab051b3c

The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein.

Autor: Wu, Lanqin¹ (AUTHOR) wulanqin@fjmu.edu.cn, Lin, Yingying¹ (AUTHOR) lin_ag@fjmu.edu.cn, Feng, Jinan¹ (AUTHOR) fjn930104@fjmu.edu.cn, Qi, Yuanlin¹ (AUTHOR) ylqi@fjmu.edu.cn, Wang, Xinrui² (AUTHOR) wanxiru@mail.sjtu.edu.cn, Lin, Qiaofa¹ (AUTHOR) lqf@fjmu.edu.cn, Shi, Wanyan¹ (AUTHOR) shiwanyan@fjmu.edu.cn, Zheng, Enrun¹ (AUTHOR) zhengenrun@fjmu.edu.cn, Wang, Wei¹ (AUTHOR) wangwei980423@fjmu.edu.cn, Hou, Zhenzhu¹ (AUTHOR) 1030300881@qq.com, Lin, Hanbin¹ (AUTHOR) 584746275@qq.com, Yu, Cheng¹ (AUTHOR) yc@fjmu.edu.cn, He, Yan¹ (AUTHOR) hyhyj2002@fjmu.edu.cn, Xu, Yan¹ (AUTHOR) xyan_2014@fjmu.edu.cn, Yang, Hong¹ (AUTHOR) yanghong@fjmu.edu.cn, Lin, Ling¹ (AUTHOR) llinzheng@fjmu.edu.cn, Li, Lisheng^1,3 (AUTHOR) lilisheng218@fjmu.edu.cn

Publikováno v: Cancer Cell International. 8/27/2019, Vol. 19 Issue 1, pN.PAG-N.PAG. 1p.