Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Zhenzhong Cui"'
Autor:
Dhanush Haspula, Zhenzhong Cui
Publikováno v:
Cells, Vol 12, Iss 13, p 1801 (2023)
Precise neural regulation is required for maintenance of energy homeostasis. Essential to this are the hypothalamic and brainstem nuclei which are located adjacent and supra-adjacent to the circumventricular organs. They comprise multiple distinct ne
Externí odkaz:
https://doaj.org/article/f7ea7b6cf00b441e93bcaf036e26de4a
Autor:
Min Chen, Eric A. Wilson, Zhenzhong Cui, Hui Sun, Yogendra B. Shrestha, Brandon Podyma, Christina H. Le, Benedetta Naglieri, Karel Pacak, Oksana Gavrilova, Lee S. Weinstein
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 142-153 (2019)
Objective: Gsα couples multiple receptors, including the melanocortin 4 receptor (MC4R), to intracellular cAMP generation. Germline inactivating Gsα mutations lead to obesity in humans and mice. Mice with brain-specific Gsα deficiency also develop
Externí odkaz:
https://doaj.org/article/89acb52d5bae4dd38d177087aca8704b
Autor:
Ken-ichiro Nakajima, Zhenzhong Cui, Chia Li, Jaroslawna Meister, Yinghong Cui, Ou Fu, Adam S. Smith, Shalini Jain, Bradford B. Lowell, Michael J. Krashes, Jürgen Wess
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Hypothalamic Agouti-related peptide (AgRP) neurons play a key role in regulating food intake. Here, the authors report a novel pathway in which activation of Gs-coupled receptors on AgRP neurons leads to robust, sustained increase in food intake.
Externí odkaz:
https://doaj.org/article/d80731cbf6a5433fb3c995ee37ce1bac
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111865 (2014)
The opening-duration of the NMDA receptors implements Hebb's synaptic coincidence-detection and is long thought to be the rate-limiting factor underlying superior memory. Here, we investigate the molecular and genetic determinants of the NMDA recepto
Externí odkaz:
https://doaj.org/article/4b88ec611936408987714d2842ab5c59
Autor:
Ken-ichiro Nakajima, Zhenzhong Cui, Chia Li, Jaroslawna Meister, Yinghong Cui, Ou Fu, Adam S. Smith, Shalini Jain, Bradford B. Lowell, Michael J. Krashes, Jürgen Wess
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 7: Article number: 10268 (2016); Published: 8 January 2016; Updated: 3 March 2016 The financial support for this article was not fully acknowledged. The Acknowledgements should have included the following: This work was supporte
Externí odkaz:
https://doaj.org/article/17bc28f416864b8baa553db68542bb9e
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19326 (2011)
Pattern completion, the ability to retrieve complete memories initiated by subsets of external cues, has been a major focus of many computation models. A previously study reports that such pattern completion requires NMDA receptors in the hippocampus
Externí odkaz:
https://doaj.org/article/a24134719c564e8796f48f971c3dc6cd
Autor:
Deheng Wang, Zhenzhong Cui, Qingwen Zeng, Hui Kuang, L Phillip Wang, Joe Z Tsien, Xiaohua Cao
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7486 (2009)
One major theory in learning and memory posits that the NR2B gene is a universal genetic factor that acts as rate-limiting molecule in controlling the optimal NMDA receptor's coincidence-detection property and subsequent learning and memory function
Externí odkaz:
https://doaj.org/article/f0daec6b0d41463ab68abf3969a214b0
Autor:
Dhanush Haspula, Zhenzhong Cui
Keywords: Obesity; hypothalamus; appetite; glucose homeostasis; weight-loss drugs; AGRP; POMC; NTS; incretins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0618351a8c3a048821bbfef6262fe2a
https://doi.org/10.20944/preprints202305.0130.v1
https://doi.org/10.20944/preprints202305.0130.v1
Autor:
Lee S. Weinstein, Mritunjay Pandey, Oksana Gavrilova, Hui Sun, Zhenzhong Cui, Min Chen, Marshal T Jahnke, Eric A. Wilson, Peter Metzger
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 320:E270-E280
This paper demonstrates that signaling within the dorsomedial hypothalamus via the G proteins Gqα and G11α, which couple cell surface receptors to the stimulation of phospholipase C, is critical for regulation of energy expenditure, thermoregulatio
Autor:
Ioannis Papazoglou, Ji-Hyeon Lee, Zhenzhong Cui, Chia Li, Gianluca Fulgenzi, Young Jae Bahn, Halina M. Staniszewska-Goraczniak, Ramón A. Piñol, Ian B. Hogue, Lynn W. Enquist, Michael J. Krashes, Sushil G. Rane
Publikováno v:
Cell Metab
The central nervous system has long been thought to regulate insulin secretion, an essential process in the maintenance of blood glucose levels. However, the anatomical and functional connections between the brain and insulin-producing pancreatic β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a956541588cab92d164b2a5b42326b
https://europepmc.org/articles/PMC8935365/
https://europepmc.org/articles/PMC8935365/