Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Zhenyu, Ju"'
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract YTHDC1, a reader of N6-methyladenosine (m6A) modifications on RNA, is posited to exert significant influence over RNA metabolism. Despite its recognized importance, the precise function and underlying mechanisms of YTHDC1 in the preservation
Externí odkaz:
https://doaj.org/article/6d8fe684599542cb9b2bccf5dd3f329d
Autor:
Fangshu Liu, Xiaofan Sun, Suqi Deng, Yingying Wu, Xingcheng Liu, Caiping Wu, Kexiu Huang, Yue Li, Zexuan Dong, Weihao Xiao, Manchun Li, Zhiyang Chen, Zhenyu Ju, Jia Xiao, Juan Du, Hui Zeng
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Background The function of hematopoietic stem cells (HSC) is regulated by HSC internal signaling pathways and their microenvironment. Chemokines and chemokine ligands play important roles in the regulation of HSC function. Yet, their functio
Externí odkaz:
https://doaj.org/article/9c34e27f5169431ca7ec244444d600ba
Autor:
Cihang Liu, Yunping Lin, Ying Wang, Shuyong Lin, Jing Zhou, Hao Tang, Xia Yi, Zhengliang Ma, Tianjiao Xia, Bin Jiang, Feng Tian, Zhenyu Ju, Baohua Liu, Xiaoping Gu, Zhongzhou Yang, Wengong Wang
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114238- (2024)
Summary: Triacylglyceride (TAG) synthesis in the small intestine determines the absorption of dietary fat, but the underlying mechanisms remain to be further studied. Here, we report that the RNA-binding protein HuR (ELAVL1) promotes TAG synthesis in
Externí odkaz:
https://doaj.org/article/2ea5e26ac35541a4a935b63ffabd641d
Publikováno v:
Bioactive Materials, Vol 27, Iss , Pp 560-573 (2023)
The therapeutic efficacy of radioimmunotherapy against triple negative breast cancer (TNBC) is largely limited by the complicated tumor microenvironment (TME) and its immunosuppressive state. Thus developing a strategy to reshape TME is expected to a
Externí odkaz:
https://doaj.org/article/cc6e9b65a4ac47e8a073b6be9b2c03f7
Autor:
Bo Liu, Yuanyuan Zhou, Qiaofeng Wu, Yuting Fu, Xianli Zhang, Zhenkun Wang, Weiwei Yi, Hu Wang, Zhiyang Chen, Zhangfa Song, Wei Xiong, Yugang Qiu, Weifeng He, Zhenyu Ju
Publikováno v:
Cell Death and Disease, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Excessive protein synthesis upon enhanced cell proliferation frequently results in an increase of unfolded or misfolded proteins. During hematopoietic regeneration, to replenish the hematopoietic system, hematopoietic stem cells (HSCs) are a
Externí odkaz:
https://doaj.org/article/ae965158b2c44045b27e50b02f805fb8
Autor:
Tie‐Gang Meng, Jia‐Ni Guo, Liu Zhu, Yike Yin, Feng Wang, Zhi‐Ming Han, Lei Lei, Xue‐Shan Ma, Yue Xue, Wei Yue, Xiao‐Qing Nie, Zheng‐Hui Zhao, Hong‐Yong Zhang, Si‐Min Sun, Ying‐Chun Ouyang, Yi Hou, Heide Schatten, Zhenyu Ju, Xiang‐Hong Ou, Zhen‐Bo Wang, Catherine C. L. Wong, Zhonghan Li, Qing‐Yuan Sun
Publikováno v:
Advanced Science, Vol 10, Iss 27, Pp n/a-n/a (2023)
Abstract Sperm‐induced Ca2+ rise is critical for driving oocyte activation and subsequent embryonic development, but little is known about how lasting Ca2+ oscillations are regulated. Here it is shown that NLRP14, a maternal effect factor, is essen
Externí odkaz:
https://doaj.org/article/47580a10099a4e6e94ff73db2cf2e674
Autor:
Yuhe Liu, Xueyu Chen, Xuan Deng, Fan Yang, Jinping Zheng, Tianyun Zhou, Ling Xu, Xiaomei Xie, Zhenyu Ju, Baoguo Wang, Caiping Zhang, Yong Zhou
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundNicotinamide adenine dinucleotide (NAD+) is a coenzyme and plays a crucial role in several metabolic processes. This study explored the association of nicotinamide adenine dinucleotide (NAD+) levels with metabolic disease (MD) in adults.Met
Externí odkaz:
https://doaj.org/article/a806614db712494fbc792925bf6ef89e
Autor:
Wentao Duan, Zexian Ou, Yuxing Huang, Yifan Zhang, Lan Zhang, Yanan Zhao, Ruikun He, Yihan Zhang, Yuanlong Ge, Huiling Lou, Zhenyu Ju, Qian Hu
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2119 (2023)
Ferroptosis is involved in various tissue injuries including neurodegeneration, ischemia-reperfusion injury, and acute liver injury. Ferroptosis inhibitors exhibit promising clinical potential in the treatment of various diseases. As a traditional ch
Externí odkaz:
https://doaj.org/article/52b846233cd14be4941861e864b28bb7
Autor:
Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in
Externí odkaz:
https://doaj.org/article/5e54229427a044a9afccbf8998af649c
Autor:
Miaoqin Chen, Weikai Wang, Shiman Hu, Yifan Tong, Yiling Li, Qi Wei, Lei Yu, Liyuan Zhu, Yiran Zhu, Leiming Liu, Zhenyu Ju, Xian Wang, Hongchuan Jin, Lifeng Feng
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Hepatocellular carcinoma (HCC) is one of the most fatal cancers. Due to limited strategies for effective treatments, patients with advanced HCC have a very poor prognosis. This study aims to identify new insights in HCC to develop
Externí odkaz:
https://doaj.org/article/07b7fe8777ae45a0b443aaa3f1044f36