Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Zhenxing Liao"'
1
Akademický článek
Novel insights in the pathomechanism of Brugada syndrome and fever‐related type 1 ECG changes in a preclinical study using human‐induced pluripotent stem cell‐derived cardiomyocytes
Autor: Yingrui Li, Hendrik Dinkel, Dalia Pakalniskyte, Alexandra Viktoria Busley, Lukas Cyganek, Rujia Zhong, Feng Zhang, Qiang Xu, Lasse Maywald, Assem Aweimer, Mengying Huang, Zhenxing Liao, Zenghui Meng, Chen Yan, Timo Prädel, Lena Rose, Alexander Moscu‐Gregor, Alyssa Hohn, Zhen Yang, Lin Qiao, Andreas Mügge, Xiaobo Zhou, Ibrahim Akin, Ibrahim El‐Battrawy
Publikováno v: Clinical and Translational Medicine, Vol 13, Iss 3, Pp n/a-n/a (2023)
Abstract Background Brugada syndrome (BrS) is causing sudden cardiac death (SCD) mainly at young age. Studying the underlying mechanisms associated with BrS type I electrocardiogram (ECG) changes in the presence of fever and roles of autophagy for Br
Externí odkaz: https://doaj.org/article/c96503a7f7184eef92bef287fc6cc881
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3
Akademický článek
Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1
Autor: Mengying Huang, Zhenxing Liao, Xin Li, Zhen Yang, Xuehui Fan, Yingrui Li, Zhihan Zhao, Siegfried Lang, Lukas Cyganek, Xiaobo Zhou, Ibrahim Akin, Martin Borggrefe, Ibrahim El-Battrawy
Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Aims: The short QT syndrome type 1 (SQT1) is linked to hERG channel mutations (e.g., N588K). Drug effects on hERG channel gating kinetics in SQT1-cells have not been investigated.Methods: This study used hiPSC-CMs of a healthy donor and a SQT1-patien
Externí odkaz: https://doaj.org/article/2f5fe5842def4a55bdbdf25d5c1e9677
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4
Akademický článek
Lipopolysaccharide Modifies Sodium Current Kinetics through ROS and PKC Signalling in Induced Pluripotent Stem-Derived Cardiomyocytes from Brugada Syndrome Patient
Autor: Zhenxing Liao, Yingrui Li, Xuehui Fan, Zhen Yang, Ibrahim El-Battrawy, Xiaobo Zhou, Ibrahim Akin
Publikováno v: Journal of Cardiovascular Development and Disease, Vol 9, Iss 4, p 119 (2022)
Studies have suggested a connection between inflammation and arrhythmogenesis of Brugada syndrome (BrS). However, experimental studies regarding the roles of inflammation in the arrhythmogenesis of BrS and its underlying mechanism are still lacking.
Externí odkaz: https://doaj.org/article/dff0f1cd0bb6462ebab5f42c0d5f2328
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5
Akademický článek
Studying Brugada Syndrome With an SCN1B Variants in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Autor: Ibrahim El-Battrawy, Jonas Müller, Zhihan Zhao, Lukas Cyganek, Rujia Zhong, Feng Zhang, Mandy Kleinsorge, Huan Lan, Xin Li, Qiang Xu, Mengying Huang, Zhenxing Liao, Alexander Moscu-Gregor, Sebastian Albers, Hendrik Dinkel, Siegfried Lang, Sebastian Diecke, Wolfram-Hubertus Zimmermann, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 7 (2019)
BackgroundAmong rare channelopathies BrS patients are at high risk of sudden cardiac death (SCD). SCN5A mutations are found in a quarter of patients. Other rare gene mutations including SCN1B have been implicated to BrS. Studying the human cellular p
Externí odkaz: https://doaj.org/article/e4d847f1203f41bca3784f5844070f87
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8
A preclinical study on brugada syndrome with a CACNB2 variant using human cardiomyocytes from induced pluripotent stem cells
Autor: Rujia Zhong, Theresa Schimanski, Feng Zhang, Huan Lan, Alyssa Hohn, Qiang Xu, Mengying Huang, Zhenxing Liao, Lin Qiao, Zhen Yang, Yingrui Li, Zhihan Zhao, Xin Li, Lena Rose, Sebastian Albers, Lasse Maywald, Jonas Müller, Hendrik Dinkel, Ardan Saguner, Johannes W. G. Janssen, Narasimha Swamy, Yannick Xi, Siegfried Lang, Mandy Kleinsorge, Firat Duru, Xiaobo Zhou, Sebastian Diecke, Lukas Cyganek, Ibrahim Akin, Ibrahim El-Battrawy
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8313
Aims: Some gene variants in the sodium channels, as well as calcium channels, have been associated with Brugada syndrome (BrS). However, the investigation of the human cellular phenotype and the use of drugs for BrS in presence of variant in the calc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d0c75e8753b16a16f8bb81ae310374
http://edoc.mdc-berlin.de/22016/7/22016suppl.zip
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10
Acoustic Emission Intelligent Prediction of Grinding Surface Roughness Based on BP Neural Network
Autor: Yongfeng Ma, Xun Chen, Bo Li, Zhenxing Liao, Yi Wang, Li Guo, Chong Wang
Publikováno v: 2020 3rd World Conference on Mechanical Engineering and Intelligent Manufacturing (WCMEIM).
Aiming at the problem of low precision of on-line prediction of grinding surface roughness by back-propagation (BP) neural network, based on the acoustic emission (AE) prediction experiment of surface roughness of nodular cast iron QT700-2, 13 charac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19102978b37b7351fd5c8b6f2424f430
https://doi.org/10.1109/wcmeim52463.2020.00084
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