The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network

Autor: Zhiying Yao, Yi Liu, Qi Chen, Xiaoxin Chen, Zhenshuo Zhu, Sha Song, Xianjue Ma, Peiguo Yang

Publikováno v: Cell Reports, Vol 43, Iss 8, Pp 114617- (2024)

Summary: Liquid-liquid phase separation (LLPS) mediated by G3BP1/2 proteins and non-translating mRNAs mediates stress granule (SG) assembly. We investigated the phylogenetic evolution of G3BP orthologs from unicellular yeast to mammals and identified

Externí odkaz: https://doaj.org/article/9ca2970e49a94520a7f5312b819d9749

Super-enhancers conserved within placental mammals maintain stem cell pluripotency

Autor: Juqing Zhang, Yaqi Zhou, Wei Yue, Zhenshuo Zhu, Xiaolong Wu, Shuai Yu, Qiaoyan Shen, Qin Pan, Wenjing Xu, Rui Zhang, Xiaojie Wu, Xinmei Li, Yayu Li, Yunxiang Li, Yu Wang, Sha Peng, Shiqiang Zhang, Anmin Lei, Xinbao Ding, Fan Yang, Xingqi Chen, Na Li, Mingzhi Liao, Wei Wang, Jinlian Hua

Publikováno v: Proceedings of the National Academy of Sciences. 119

Despite pluripotent stem cells sharing key transcription factors, their maintenance involves distinct genetic inputs. Emerging evidence suggests that super-enhancers (SEs) can function as master regulatory hubs to control cell identity and pluripoten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6966d34f9dbf3afe0d2574bbaeabe20
https://doi.org/10.1073/pnas.2204716119

LIN28A inhibits DUSP family phosphatases and activates MAPK signaling pathway to maintain pluripotency in porcine induced pluripotent stem cells

Autor: Rui Zhang, Wei Yue, Shuai Yu, Xin He, Jinlian Hua, Zhenshuo Zhu, Juqing Zhang, Shiqiang Zhang, Sha Peng, Xia Xiao, Qiaoyan Shen, Xiaolong Wu, Zhe Zhou, Na Li, Mingzhi Liao

Publikováno v: Zoological Research. 42:377-388

LIN28A, an RNA-binding protein, plays an important role in porcine induced pluripotent stem cells (piPSCs). However, the molecular mechanism underlying the function of LIN28A in the maintenance of pluripotency in piPSCs remains unclear. Here, we expl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73710eab5ca7b83eb0b23d9860c84578
https://doi.org/10.24272/j.issn.2095-8137.2020.375

AXIN2 Reduces the Survival of Porcine Induced Pluripotent Stem Cells (piPSCs)

Autor: Xiaolong Wu, Li Na, Qiaoyan Shen, Shuai Yu, Zhenshuo Zhu, Xiaojie Wu, Juqing Zhang, Hua Jinlian, Rui Zhang, Sha Peng, Wenxu Zhao

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12954
International Journal of Molecular Sciences, Vol 22, Iss 12954, p 12954 (2021)

BackgroundThe establishment of porcine pluripotent stem cells (piPSCs) is still a critical topic and challenging issue. However, all piPSCs are extremely sensitive to changes of the culture conditions.In addition, the side effect of inhibitors in cul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f51f83e95dbe2255373257a360db43
http://europepmc.org/articles/PMC8658036

Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to define a pluripotency gene regulatory network

Autor: Xiaolong Wu, Yiliang Miao, Qun Li, Anmin Lei, Xingqi Chen, Wenxu Zhao, Qin Pan, Juqing Zhang, Dezhe Qin, Zhonghua Liu, Na Li, Jinlian Hua, Qiaoyan Shen, Wei Yue, Shuai Yu, Huayan Wang, Ying Zhang, Mingzhi Liao, Shiqiang Zhang, Zhenshuo Zhu, Zhe Zhou, Sha Peng, Rui Zhang

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(6)

The pluripotency gene regulatory network of porcine induced pluripotent stem cells(piPSCs), especially in epigenetics, remains elusive. To determine the biological function of epigenetics, we cultured piPSCs in different culture conditions. We found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3240d745a9089cbbb48ad9bda8d35f3d
https://pubmed.ncbi.nlm.nih.gov/34143506