Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Zhenqing Ye"'
Autor:
Yifan Wu, Kunhua Qin, Yi Xu, Shreya Rajhans, Truong Vo, Kevin M Lopez, Jun Liu, Michael H Nipper, Janice Deng, Xue Yin, Logan R Ramjit, Zhenqing Ye, Yu Luan, H Efsun Arda, Pei Wang
Publikováno v:
eLife, Vol 13 (2024)
The Hippo pathway plays a central role in tissue development and homeostasis. However, the function of Hippo in pancreatic endocrine development remains obscure. Here, we generated novel conditional genetically engineered mouse models to examine the
Externí odkaz:
https://doaj.org/article/fcd1f038f292418caf335b1b1a98c094
Autor:
Yi Xu, Michael H. Nipper, Angel A. Dominguez, Zhenqing Ye, Naoki Akanuma, Kevin Lopez, Janice J. Deng, Destiny Arenas, Ava Sanchez, Francis E. Sharkey, Colin M. Court, Aatur D. Singhi, Huamin Wang, Martin E. Fernandez-Zapico, Lu-Zhe Sun, Siyuan Zheng, Yidong Chen, Jun Liu, Pei Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC). However, the tumorigenic potential of human pancreatic acinar cells remains under debate. To address this gap
Externí odkaz:
https://doaj.org/article/3ae4e657182c429c839f4021884860ba
Autor:
Thanh Thanh L. Nguyen, Duan Liu, Huanyao Gao, Zhenqing Ye, Jeong‐Heon Lee, Lixuan Wei, Jia Yu, Lingxin Zhang, Liewei Wang, Tamas Ordog, Richard M. Weinshilboum
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 11, Pp 2758-2771 (2022)
Abstract Alternative polyadenylation (APA) is a common genetic regulatory mechanism that generates distinct 3′ ends for RNA transcripts. Changes in APA have been associated with multiple biological processes and disease phenotypes. However, the rol
Externí odkaz:
https://doaj.org/article/9e5c3f5bc7ca48ffa83f71f51b41317a
Autor:
Kirsten G. M. Aspros, Jodi M. Carter, Tanya L. Hoskin, Vera J. Suman, Malayannan Subramaniam, Michael J. Emch, Zhenqing Ye, Zhifu Sun, Jason P. Sinnwell, Kevin J. Thompson, Xiaojia Tang, Esther P. B. Rodman, Xiyin Wang, Adam W. Nelson, Igor Chernukhin, Feda H. Hamdan, Elizabeth S. Bruinsma, Jason S. Carroll, Martin E. Fernandez-Zapico, Steven A. Johnsen, Krishna R. Kalari, Haojie Huang, Roberto A. Leon-Ferre, Fergus J. Couch, James N. Ingle, Matthew P. Goetz, John R. Hawse
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Triple Negative Breast Cancer (TNBC) accounts for 15–20% of all breast cancer cases, yet is responsible for a disproportionately high percentage of breast cancer mortalities. Thus, there is an urgent need to identify novel biomarkers and t
Externí odkaz:
https://doaj.org/article/cb14a3f8cc2f47efa372c800d589e31a
Autor:
Yundong He, Ting Wei, Zhenqing Ye, Jacob J. Orme, Dong Lin, Haoyue Sheng, Ladan Fazli, R. Jeffrey Karnes, Rafael Jimenez, Liguo Wang, Liewei Wang, Martin E. Gleave, Yuzhuo Wang, Lei Shi, Haojie Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Resistance to second generation anti-androgen therapies such as enzalutamide (ENZ) can emerge in prostate cancer patients. Here, the authors identify an ENZ-resistant mechanism driven by AR-dependent transcription of noncanonical targets that make re
Externí odkaz:
https://doaj.org/article/00b4af7118804738bdce75145ea247c5
Publikováno v:
eLife, Vol 11 (2022)
Quantifying the activity of gene expression signatures is common in analyses of single-cell RNA sequencing data. Methods originally developed for bulk samples are often used for this purpose without accounting for contextual differences between bulk
Externí odkaz:
https://doaj.org/article/d2f8209dc90f43d9bbcdc5cb2beb46ca
Autor:
Jian Zhong, Zhenqing Ye, Chad R. Clark, Samuel W. Lenz, Justin H. Nguyen, Huihuang Yan, Keith D. Robertson, Gianrico Farrugia, Zhiguo Zhang, Tamas Ordog, Jeong-Heon Lee
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Epigenetic dysregulation is involved in the etiology and progression of various human diseases. Formalin-fixed paraffin-embedded (FFPE) samples represent the gold standard for archiving pathology samples, and thus FFPE samples are
Externí odkaz:
https://doaj.org/article/7044fd314269429e899c2c3944ee3a97
Autor:
Jian Zhong, Zhenqing Ye, Samuel W. Lenz, Chad R. Clark, Adil Bharucha, Gianrico Farrugia, Keith D. Robertson, Zhiguo Zhang, Tamas Ordog, Jeong-Heon Lee
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Chromatin immunoprecipitation-sequencing (ChIP-seq) is a widely used epigenetic approach for investigating genome-wide protein-DNA interactions in cells and tissues. The approach has been relatively well established but several ke
Externí odkaz:
https://doaj.org/article/029d36e793094dfa8c6688c1c165354c
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract Background The sequence logo has been widely used to represent DNA or RNA motifs for more than three decades. Despite its intelligibility and intuitiveness, the traditional sequence logo is unable to display the intra-motif dependencies and
Externí odkaz:
https://doaj.org/article/8033d5b9c8fb48e3b477e55e36cb519f
Autor:
Di Wu, Mei Wang, Xingang Wang, Ningbei Yin, Tao Song, Haidong Li, Feng Zhang, Yongbiao Zhang, Zhenqing Ye, Jun Yu, Duen-Mei Wang, Zhenmin Zhao
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46477 (2012)
Cleft lip with or without palate (CL/P) is a common congenital anomaly with a high birth prevalence in China. Based on a previous linkage signal of nonsyndromic CL/P (NSCL/P) on the chromosomal region 4q31-q32 from the Chinese populations, we screene
Externí odkaz:
https://doaj.org/article/48f058ad58b64481a858afddb76af28e