Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Zhenping Tian"'
Autor:
Zhenping Tian, Roger W. Roeske
Publikováno v:
International Journal of Peptide and Protein Research. 37:425-429
A novel guanidination method of converting a peptide side chain amino group to a guanidino group on a solid support is described. Four guanidinating reagents were evaluated using a model tetrapeptide attached to a polystyrene resin. Experimental data
Publikováno v:
International Journal of Peptide and Protein Research. 43:471-476
We have examined the effect of C α -methyl groups on the conformational ensemble of GnRH analog peptides by comparing 1 2D NMR data from two analogs, Ac-D-Nal 1 -D-4-Cl-C α -Me-Phe 2 -D-Pal 3 -Ser 4 -Tyr 5 -D-Arg 6 -Leu 7 -Arg 8 -Pro 9 -D-Ala 10 -N
Publikováno v:
International Journal of Peptide and Protein Research. 40:119-126
Optically pure L-(+)-C alpha-methyl-arginine and D-(-)-C alpha-methyl-arginine were synthesized. Experimental results indicated that DL-C alpha-methyl-arginine methyl ester could be resolved by trypsin, but workup posed a technical difficulty. Chemic
Publikováno v:
International Journal of Peptide and Protein Research. 42:155-158
A practical and convenient procedure for making phosphotyrosine-containing peptides by the solid-phase method was developed. Phosphotyrosine was incorporated via Boc-Tyr(PO3Bzl2)-OH. The completed peptide was cleaved from the solid support by treatme
Autor:
Phong Nguyen, Sue J. Swanson, Jyoti R. Patel, Jiahong Wang, Annika Goos-Nilsson, J.T. Link, Peer B. Jacobson, Zhenping Tian, Marlena Grynfarb, Jia Du, James M. Schmidt, Brad Zinker, Thomas W von Geldern, Steven Fung, Thomas J Reisch, Denise Wilcox, Gary Rotert, Benjamin C. Lane, Bach Hickman, Bryan Sorensen
Publikováno v:
Journal of Medicinal Chemistry. 48:5295-5304
Much has been learned about the consequences of glucocorticoid receptor antagonism by studying steroidal active antagonists such as RU-38486 (1). In the liver glucocorticoid receptor antagonism suppresses hepatic glucose production decreasing plasma
Autor:
Michael Rasmussen, Maureen A. McLaughlin, Ashok K. Gupta, Steven J. Wittenberger, Sukumar Manna, David R. Hill, Lakshmi Bhagavatula, David M. Barnes, Paul J. Nichols, Zhenping Tian, John J. Demattei, Ramiya H. Premchandran
Publikováno v:
Tetrahedron: Asymmetry. 14:3541-3551
A practical synthesis of neuraminidase influenza inhibitor, A-322278, has been developed. Asymmetry is introduced into the synthesis by an enzyme mediated ester hydrolysis. A highly diastereoselective vinylogous Mannich condensation reaction of N-Boc
Autor:
Michael G. Fickes, Zhenping Tian, Shyamal Parekh, Todd S. Mcdermott, Sou-Jen Chang, Steven J. Wittenberger, Ashok K. Gupta, Dilinie P. Fernando, David R. Hill
Publikováno v:
Organic Process Research & Development. 6:329-335
A process for the preparation of matrix metalloproteinase inhibitor ABT-518 has been developed. Significant improvements have been made to the first generation synthesis and are described here. The new process is very robust and efficient; multikilog
Publikováno v:
Synthetic Communications. 29:2841-2845
A procedure for the efficient direct guanylation of peptides has been developed. A model peptide was guanylated directly using (ethylamino)(ethylimino) methanesulfonic acid.
Publikováno v:
Organic Process Research & Development. 6:416-418
A safe, reliable and scalable process for the preparation of N-Boc-2-tert-butyldimethylsiloxy-pyrrole (TBSOP) is described. In a three-step, one-pot sequence (±)-4-amino-3-hydroxybutyric acid was converted to N-Boc-4-hydroxy-2-pyrrolidinone. This st
Publikováno v:
Tetrahedron Letters. 34:3659-3662
A mild N-alkylation method has been developed for the synthesis of N-alkylated pyridiniumcarboxylic acids, using Ag2O-H2O catalysis to enhance the low-reactivity of pyridinecarboxylic acids. Two approaches were undertaken for the synthesis of a serie